Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Selina Bayly"'
Autor:
Thomas G. O'Riordan, Jenny Zhang, Emmanuel Moreau, Paul W. Noble, Kevin F. Gibson, Jin Woo Song, Fernando J. Martinez, Victoria Smith, Harold R. Collard, Athol U. Wells, Vincent Cottin, Selina Bayly, Qi Gong, Kevin K. Brown, Ganesh Raghu, Scott D. Patterson, Wim A. Wuyts, Timothy P.M. Whelan, Jason W. Chien, David J. Lederer, Robert J. Kaner
Publikováno v:
The Lancet Respiratory Medicine. 5:22-32
Summary Background Lysyl oxidase-like 2 (LOXL2) catalyses collagen cross-linking and is implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The aim of this study was to investigate the efficacy and safety of simtuzumab, a monoclona
Autor:
Kevin K. Brown, Harold R. Collard, Selina Bayly, Scott D. Patterson, Jin Woo Song, Timothy J. Whelan, Fernando J. Martinez, Thomas G. O'Riordan, Ganesh Raghu, Athol U. Wells, Jennifer Zhang, Paul W. Noble, David J. Lederer, Jason W. Chien, Emmanuel Moreau
Publikováno v:
1.5 Diffuse Parenchymal Lung Disease.
Simtuzumab is a monoclonal antibody against the lysl-oxidase like-2 (LOXL2) enzyme. 544 subjects with idiopathic pulmonary fibrosis (IPF) were randomized, 1:1, to either simtuzumab 125 mg subcutaneously once per week or placebo. The study was prematu