Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure–Activity Relationship and Target Identification Studies

Autor: Wilson, Colin R, Gessner, Richard K, Moosa, Atica, Seldon, Ronnett, Warner, Digby F, Mizrahi, Valerie, Soares de Melo, Candice, Simelane, Sandile B, Nchinda, Aloysius, Abay, Efrem, Taylor, Dale, Njoroge, Mathew, Brunschwig, Christel, Lawrence, Nina, Boshoff, Helena I M, Barry, Clifton E, Sirgel, Frederick A, van Helden, Paul, Harris, C John, Gordon, Richard, Ghidelli-Disse, Sonja, Pflaumer, Hannah, Boesche, Markus, Drewes, Gerard, Sanz, Olalla, Santos, Gracia, Rebollo-Lopez, Maria José, Urones, Beatriz, Selenski, Carolyn, Lafuente-Monasterio, Maria Jose, Axtman, Matthew, Lelièvre, Joël, Ballell, Lluis, Mueller, Rudolf, Street, Leslie J, Ghorpade, Sandeep R, Chibale, Kelly

Publikováno v: Journal of Medicinal Chemistry
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

A BioFocus DPI SoftFocus library of ∼35 000 compounds was screened against Mycobacterium tuberculosis (Mtb) in order to identify novel hits with antitubercular activity. The hits were evaluated in biology triage assays to exclude compounds suggeste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::37b3fd45d5467f6c625df281433a5c7d
http://europepmc.org/articles/PMC5748279

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Correction to The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold

Autor: Sandoval, Elena, Lafuente-Monasterio, María José, Almela, María J., Castañeda, Pablo, Jiménez Díaz, María Belén, Martínez-Martínez, María S., Vidal, Jaume, Angulo-Barturen, Íñigo, Bamborough, Paul, Burrows, Jeremy, Cammack, Nicholas, Chaparro, María J., Coterón, José M., de Cozar, Cristina, Crespo, Benigno, Díaz, Beatriz, Drewes, Gerard, Fernández, Esther, Ferrer-Bazaga, Santiago, Fraile, María Teresa, Gamo, Francisco J., Ghidelli-Disse, Sonja, Gómez, Rubén, Haselden, John, Huss, Sophie, León, María Luisa, de Mercado, Jaime, Macdonald, Simon J. F., Martín Hernando, José Ignacio, Prats, Sara, Puente, Margarita, Rodríguez, Anne, de la Rosa, Juan C., Rueda, Lourdes, Selenski, Carolyn, Willis, Paul, Wilson, David M., Witty, Michael, Calderón, Félix

Publikováno v: Journal of Medicinal Chemistry; 20240101, Issue: Preprints

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Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.

Autor: Peiling Chen, Chaikuad, Apirat, Bamborough, Paul, Bantscheff, Marcus, Bountra, Chas, Chun-wa Chung, Fedorov, Oleg, Grandi, Paola, Jung, David, Lesniak, Robert, Lindon, Matthew, Müller, Susanne, Philpott, Martin, Prinjha, Rab, Rogers, Catherine, Selenski, Carolyn, Tallant, Cynthia, Werner, Thilo, Willson, Timothy M., Knapp, Stefan

Publikováno v: Journal of Medicinal Chemistry; Feb2016, Vol. 59 Issue 4, p1410-1424, 15p