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pro vyhledávání: '"Selenocysteine insertion sequence binding"'
Akademický článek
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Autor:
Yoshiro Saito, Mototada Shichiri, Takashi Hamajima, Noriko Ishida, Yuichiro Mita, Shohei Nakao, Yoshihisa Hagihara, Yasukazu Yoshida, Kazuhiko Takahashi, Etsuo Niki, Noriko Noguchi
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 11, Pp 2172-2182 (2015)
Selenocysteine (Sec) insertion sequence-binding protein 2 (SBP2) is essential for the biosynthesis of Sec-containing proteins, termed selenoproteins. Subjects with mutations in the SBP2 gene have decreased levels of several selenoproteins, resulting
Externí odkaz:
https://doaj.org/article/52e6210220d44338b23807ca32767942
Autor:
Lidan Zhao, Christopher M Carmean, Alexandra M. Dumitrescu, Michael Landeche, Bijoy Chellan, Robert M. Sargis
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Selenoproteins are a group of selenocysteine-containing proteins with major roles in cellular antioxidant defense and thyroid hormone metabolism. Selenoprotein expression is determined by hierarchical mechanisms that result in tissue-specific levels.
Autor:
Nurgun Kandemir, Jiao Fu, Alexandra M. Dumitrescu, Xiao Hui Liao, Manassawee Korwutthikulrangsri, Laura Sillers, Roy E. Weiss, Kenneth D. Burman, E. Nazli Gonc, Maria Belen Menucci, Ayfer Alikasifoglu
Publikováno v:
J Clin Endocrinol Metab
Context Selenocysteine insertion sequence binding protein 2 (SECISBP2, SBP2) is an essential factor for selenoprotein synthesis. Individuals with SBP2 defects have characteristic thyroid function test (TFT) abnormalities resulting from deficiencies i
Publikováno v:
Biochemical and Biophysical Research Communications. 506:536-542
Disordered osteoblastic differentiation of bone marrow mesenchymal stem cells (BMSCs) contributes to bone loss. The underlying mechanisms are complicated and not fully understood. Long non-coding RNAs (lncRNAs) are emerging as an important regulatory
Autor:
Binshang Lan, Zhuqing Xia, Jian Sun, Jianli Xue, Bin Cheng, Kunzheng Wang, Fujun Zhang, Zixin Min, Yan Han
Publikováno v:
BMC Musculoskeletal Disorders, Vol 19, Iss 1, Pp 1-10 (2018)
BMC Musculoskeletal Disorders
BMC Musculoskeletal Disorders
Background The phenotypes of osteoarthritis (OA) consist of cartilage extracellular matrix (ECM) metabolism disorder and the breakdown of cartilage homeostasis, which are induced by pro-inflammatory factors and oxidative stress. Selenoproteins regula
Autor:
Xiaoyan Hu, Wanpeng Cheng, Tingting Nie, Mengdi Li, Hui Li, Jincheng Luo, Fenglan Li, Hehuan Lai, Xiaolin Zheng
Publikováno v:
Placenta. 55:81-89
Selenocysteine insertion binding protein 2 (SECISBP2) plays a vital role in selenocysteine incorporation into selenoprotein in many creatures. However, the impact of SECISBP2 in development of trophoblast cells remains unclear. The aim of this study
Autor:
Alexandra M. Dumitrescu, Haruki Fujisawa, Bumin Dündar, Taha Reşid Özdemir, Ozgur Kirbiyik, Mizuho S. Mimoto, Gönül Çatlı, Pinar Gencpinar
Publikováno v:
Thyroid. 28:1221-1223
SECISBP2 is an essential factor in selenoprotein synthesis, and its mutations result in a multiorgan syndrome, including abnormal thyroid hormone metabolism. A 10-year-old obese Turkish boy born to consanguineous parents presented with high thyroxine
Autor:
Katsuhiko Tsunekawa, Seon-Yong Jeong, Masami Murakami, Eunkuk Park, Jeonghyun Kim, Osamu Araki, Jaehoon Jung, So-Young Park, Sihoon Lee
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
Deiodinase 2 (DIO2) plays an important role in thyroid hormone metabolism and its regulation. However, molecular mechanism that regulates DIO2 activity remains unclear; only mutaions in selenocysteine insertion sequence binding protein 2 and selenocy
Autor:
Mototada Shichiri, Takashi Hamajima, Yasukazu Yoshida, Kazuhiko Takahashi, Yoshiro Saito, Noriko Noguchi, Yoshihisa Hagihara, Noriko Ishida, Shohei Nakao, Etsuo Niki, Yuichiro Mita
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 11, Pp 2172-2182 (2015)
Journal of Lipid Research
Journal of Lipid Research
Selenocysteine (Sec) insertion sequence-binding protein 2 (SBP2) is essential for the biosynthesis of Sec-containing proteins, termed selenoproteins. Subjects with mutations in the SBP2 gene have decreased levels of several selenoproteins, resulting