Targeting innate immunity for neurodegenerative disorders of the central nervous system.

Autor: Andreasson KI; Department of Neurology and Neurological Sciences, Stanford Neuroscience Institute, Stanford University School of Medicine, Stanford, CA, USA., Bachstetter AD; Sanders-Brown Center on Aging, Spinal Cord and Brain Injury Research Center, and Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY, USA., Colonna M; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Ginhoux F; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore., Holmes C; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Lamb B; Department of Neurosciences, Cleveland Clinic, Cleveland, OH, USA., Landreth G; Alzheimer Research Laboratory, Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA., Lee DC; USF Health Byrd Alzheimer's Institute, Tampa, FL, USA.; College of Pharmacy & Pharmaceutical Sciences, Tampa, FL, USA., Low D; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore., Lynch MA; Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland., Monsonego A; The Shraga Segal Dept. of Microbiology, Immunology and Genetics, The Faculty of Health Sciences, The National Institute of Biotechnology in the Negev and Zlotowski Center for Neuroscience, Ben-Gurion University, Beer-Sheva, Israel., O'Banion MK; Departments of Neuroscience and Neurology, Del Monte Neuromedicine Institute, University of Rochester School of Medicine & Dentistry, Rochester, NY, USA., Pekny M; Center for Brain Repair and Rehabilitation, Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.; Hunter Medical Research Institute, University of Newcastle, New South Wales, Australia., Puschmann T; Center for Brain Repair and Rehabilitation, Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden., Russek-Blum N; The Dead Sea and Arava Science Center, Central Arava Branch, Yair Station, Hazeva, Israel., Sandusky LA; USF Health Byrd Alzheimer's Institute, Tampa, FL, USA.; College of Pharmacy & Pharmaceutical Sciences, Tampa, FL, USA., Selenica ML; USF Health Byrd Alzheimer's Institute, Tampa, FL, USA.; College of Pharmacy & Pharmaceutical Sciences, Tampa, FL, USA., Takata K; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.; Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan., Teeling J; Centre for Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, UK., Town T; Departments of Physiology and Biophysics, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Van Eldik LJ; Sanders-Brown Center on Aging, Spinal Cord and Brain Injury Research Center, and Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY, USA.

Publikováno v: Journal of neurochemistry [J Neurochem] 2016 Sep; Vol. 138 (5), pp. 653-93.

Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy.

Autor: Hunt JB Jr; Byrd Alzheimer's Institute, College of Pharmacy and Pharmaceutical Sciences, and., Nash KR; Byrd Alzheimer's Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida 33613., Placides D; Byrd Alzheimer's Institute, College of Pharmacy and Pharmaceutical Sciences, and., Moran P; Byrd Alzheimer's Institute., Selenica ML; Byrd Alzheimer's Institute, College of Pharmacy and Pharmaceutical Sciences, and., Abuqalbeen F; Byrd Alzheimer's Institute, College of Pharmacy and Pharmaceutical Sciences, and., Ratnasamy K; Byrd Alzheimer's Institute, College of Pharmacy and Pharmaceutical Sciences, and., Slouha N; Byrd Alzheimer's Institute, College of Pharmacy and Pharmaceutical Sciences, and., Rodriguez-Ospina S; Byrd Alzheimer's Institute., Savlia M; Byrd Alzheimer's Institute., Ranaweera Y; Byrd Alzheimer's Institute, College of Pharmacy and Pharmaceutical Sciences, and., Reid P; Byrd Alzheimer's Institute., Dickey CA; Byrd Alzheimer's Institute., Uricia R; Byrd Alzheimer's Institute, College of Pharmacy and Pharmaceutical Sciences, and., Yang CG; Morsani College of Medicine, University of South Florida, Tampa, Florida 33613., Sandusky LA; Byrd Alzheimer's Institute, College of Pharmacy and Pharmaceutical Sciences, and., Gordon MN; Byrd Alzheimer's Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida 33613., Morgan D; Byrd Alzheimer's Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida 33613., Lee DC; Byrd Alzheimer's Institute, College of Pharmacy and Pharmaceutical Sciences, and dlee1@health.usf.edu.

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2015 Nov 04; Vol. 35 (44), pp. 14842-60.

Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis.

Autor: Selenica ML; Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, 12901 Bruce B Downs Blvd, Tampa 33612, FL, USA. mselenic@health.usf.edu., Davtyan H, Housley SB, Blair LJ, Gillies A, Nordhues BA, Zhang B, Liu J, Gestwicki JE, Lee DC, Gordon MN, Morgan D, Dickey CA

Publikováno v: Journal of neuroinflammation [J Neuroinflammation] 2014 Sep 03; Vol. 11, pp. 152. Date of Electronic Publication: 2014 Sep 03.

Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition.

Autor: Selenica ML; Byrd Alzheimer's Institute, University of South Florida, Tampa, FL 33613, USA ; College of Pharmacy, Department of Pharmaceutical Sciences, University of South Florida, Tampa, FL 33612, USA., Benner L; Byrd Alzheimer's Institute, University of South Florida, Tampa, FL 33613, USA., Housley SB; Byrd Alzheimer's Institute, University of South Florida, Tampa, FL 33613, USA., Manchec B; Byrd Alzheimer's Institute, University of South Florida, Tampa, FL 33613, USA., Lee DC; Byrd Alzheimer's Institute, University of South Florida, Tampa, FL 33613, USA ; College of Pharmacy, Department of Pharmaceutical Sciences, University of South Florida, Tampa, FL 33612, USA., Nash KR; Byrd Alzheimer's Institute, University of South Florida, Tampa, FL 33613, USA ; College of Medicine, Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA., Kalin J; Department of Pharmacology and Molecular Science, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA., Bergman JA; Drug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA., Kozikowski A; Drug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA., Gordon MN; Byrd Alzheimer's Institute, University of South Florida, Tampa, FL 33613, USA ; College of Medicine, Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA., Morgan D; Byrd Alzheimer's Institute, University of South Florida, Tampa, FL 33613, USA ; College of Medicine, Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA.

Publikováno v: Alzheimer's research & therapy [Alzheimers Res Ther] 2014 Feb 27; Vol. 6 (1), pp. 12. Date of Electronic Publication: 2014 Feb 27 (Print Publication: 2014).

Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.

Autor: Nash KR; Molecular Pharmacology and Physiology Department, Byrd Alzheimer Institute, University of South Florida, Tampa, FL, USA. knash@health.usf.edu, Lee DC, Hunt JB Jr, Morganti JM, Selenica ML, Moran P, Reid P, Brownlow M, Guang-Yu Yang C, Savalia M, Gemma C, Bickford PC, Gordon MN, Morgan D

Publikováno v: Neurobiology of aging [Neurobiol Aging] 2013 Jun; Vol. 34 (6), pp. 1540-8. Date of Electronic Publication: 2013 Jan 16.