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Development and Evaluation of Solid Witepsol Nanoparticles for Gene Delivery

Autor: Selen Isar, Hasan Akbaba, Gülşah Erel-Akbaba

Publikováno v: Turk J Pharm Sci

Objectives: Gene therapy approaches have become increasingly attractive in the medical, pharmaceutical, and biotechnological industries due to their applicability in the treatment of diseases with no effective conventional therapy. Non-viral delivery

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a06e20e395589ebe3f437567aa05c703
https://doi.org/10.4274/tjps.galenos.2020.68878

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Design and evaluation of erucic acid-phytosphingosine structured cationic nanoemulsions as a plasmid DNA delivery system against breast cancer cells

Autor: Selen İsar, Hasan Akbaba, Yiğit Şahİn, Meric A. Altinöz, Ayşe Nalbantsoy, Gülşah Erel-Akbaba, Yücel Başpınar

This study is focused on the preparation and characterization of erucic acid (EA) and phytosphingosine (PS) containing cationic nanoemulsions (NEs) for plasmid DNA (pDNA) delivery. Repurposing of cationic agents guided us to PS, previously used for e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b93b78a3bd1ae444de3f5765df4fca7
https://hdl.handle.net/11454/77219

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Long-term Stability of Cationic Phytosphingosine Nanoemulsions as Delivery Systems for plasmid DNA

Autor: Selen ISAR, Hüseyin Yiğit ŞAHİN, Hasan AKBABA, Ayşe NALBANTSOY, Gülşah EREL AKBABA, Yücel BAŞPINAR

Publikováno v: Volume: 18, Issue: 1 107-118
Celal Bayar University Journal of Science

Gene delivery systems like cationic nanoemulsions are in general not ready to use for any time. Thus, delivery systems for genetic materials like nucleic acids have to be prepared freshly before application. This study is focused on the preparation a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd74f15c3470410ba9a7a1a1e8773d5
https://dergipark.org.tr/tr/pub/cbayarfbe/issue/69014/948114

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Development and characterization of cationicnanoemulsions as non-viral vectors for plasmid DNAdelivery

Autor: Hasan Akbaba, Selen Isar, Yücel Başpınar, Gülşah Erel-Akbaba

Gene therapy is a promising approach to treat several diseases including cancer. Unfortunately, free nucleic acids are negatively charged and not stable in blood. Cationic drug delivery systems like cationic nanoemulsions (CNEs) are useful to improve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e87fbeb3e05a5a23aa445c1f685e9d4
https://hdl.handle.net/11454/80956

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