DNA binding and RAD51 engagement by the BRCA2 C-terminus orchestrate DNA repair and replication fork preservation

Autor: Youngho Kwon, Heike Rösner, Weixing Zhao, Platon Selemenakis, Zhuoling He, Ajinkya S. Kawale, Jeffrey N. Katz, Cody M. Rogers, Francisco E. Neal, Aida Badamchi Shabestari, Valdemaras Petrosius, Akhilesh K. Singh, Marina Z. Joel, Lucy Lu, Stephen P. Holloway, Sandeep Burma, Bipasha Mukherjee, Robert Hromas, Alexander Mazin, Claudia Wiese, Claus S. Sørensen, Patrick Sung

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Exon 27 of the tumor suppressor BRCA2 encodes a portion of the protein crucial for DNA repair, genome maintenance, and tumor suppression. Here the authors show that this domain binds DNA and the RAD51 recombinase to enhance the assembly of RAD51-DNA

Externí odkaz: https://doaj.org/article/31023ba9447a4531befe74ed9fc6d0e3

Author Correction: A multiplexed, paired-pooled droplet digital PCR assay for detection of SARS-CoV-2 in saliva

Autor: Kaitlyn Wagner, Phil Fox, Elizabeth Gordon, Westen Hahn, Kenzie Olsen, Alex Markham, Dylan Buglewicz, Platon Selemenakis, Avery Lessard, Daniella Goldstein, Alissa Threatt, Luke Davis, Jake Miller-Dawson, Halie Stockett, Hailey Sanders, Kristin Rugh, Houston Turner, Michelle Remias, Maggie Williams, Jorge Chavez, Gabriel Galindo, Charlotte Cialek, Amanda Koch, Alex Fout, Bailey Fosdick, Bettina Broeckling, Mark D. Zabel

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-1 (2024)

Externí odkaz: https://doaj.org/article/2f97d876d36b4b3aad9935e4660f0424

Disparate requirements for RAD54L in replication fork reversal.

Autor: Uhrig ME, Sharma N, Maxwell P, Selemenakis P, Mazin AV, Wiese C

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 10. Date of Electronic Publication: 2024 May 10.

Author Correction: A multiplexed, paired-pooled droplet digital PCR assay for detection of SARS-CoV-2 in saliva.

Autor: Wagner K; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Fox P; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Gordon E; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Hahn W; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Olsen K; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Markham A; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Buglewicz D; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Selemenakis P; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Lessard A; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Goldstein D; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Threatt A; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Davis L; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Miller-Dawson J; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Stockett H; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Sanders H; Colorado State University, Fort Collins, CO, 80523, USA., Rugh K; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Turner H; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Remias M; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Williams M; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Chavez J; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Galindo G; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Cialek C; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Koch A; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Fout A; Department of Statistics, Colorado State University, Fort Collins, CO, 80523, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Fosdick B; Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, USA., Broeckling B; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA.; Colorado State University, Fort Collins, CO, 80523, USA., Zabel MD; Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, USA. mark.zabel@colostate.edu.; Colorado State University, Fort Collins, CO, 80523, USA. mark.zabel@colostate.edu.

Publikováno v: Scientific reports [Sci Rep] 2024 Feb 07; Vol. 14 (1), pp. 3155. Date of Electronic Publication: 2024 Feb 07.

The Nuclear Oncogene SET Controls DNA Repair by KAP1 and HP1 Retention to Chromatin

Autor: Alkmini Kalousi, Anne-Sophie Hoffbeck, Platonas N. Selemenakis, Jordan Pinder, Kienan I. Savage, Kum Kum Khanna, Laurent Brino, Graham Dellaire, Vassilis G. Gorgoulis, Evi Soutoglou

Publikováno v: Cell Reports, Vol 11, Iss 1, Pp 149-163 (2015)

Cells experience damage from exogenous and endogenous sources that endanger genome stability. Several cellular pathways have evolved to detect DNA damage and mediate its repair. Although many proteins have been implicated in these processes, only rec

Externí odkaz: https://doaj.org/article/cc2a41e5007e4ca08930877ab8c04887