Zobrazeno 1 - 10
of 1 696
pro vyhledávání: '"Selective vulnerability"'
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
Neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis (ALS) affect millions and present significant challenges in healthcare and treatment costs. The debate in the field pivots around two hypotheses: syna
Externí odkaz:
https://doaj.org/article/3ee715ad53ff439ba5509675561a844f
Autor:
Stefanie D. Pina‐Escudero, Renaud La Joie, Salvatore Spina, Ji‐Hye Hwang, Zachary A. Miller, Eric J. Huang, Harli Grant, Nidhi S. Mundada, Adam L. Boxer, Maria Luisa Gorno‐Tempini, Howard J. Rosen, Joel H. Kramer, Bruce L. Miller, William W. Seeley, Gil D. Rabinovici, Lea Tenenholz Grinberg
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 3, Pp n/a-n/a (2024)
Abstract INTRODUCTION Alzheimer's disease (AD) neuropathological changes present with amnestic and nonamnestic (atypical) syndromes. The contribution of comorbid neuropathology as a substratum of atypical expression of AD remains under investigated.
Externí odkaz:
https://doaj.org/article/3a35a738074541e6ac5d67e4c35f4e1e
Autor:
Katherine Hamel, Emmanuel Labrada Moncada, Carrie Sheeler, Juao-Guilherme Rosa, Stephen Gilliat, Ying Zhang, Marija Cvetanovic
Publikováno v:
Neurobiology of Disease, Vol 197, Iss , Pp 106530- (2024)
Summary: Heterogeneity is one of the key features of the healthy brain and selective vulnerability characterizes many, if not all, neurodegenerative diseases. While cerebellum contains majority of brain cells, neither its heterogeneity nor selective
Externí odkaz:
https://doaj.org/article/ea7a2f5bf6fe4de58c2caab364bd2d0d
Autor:
Lisa Hahn, Simon B Eickhoff, Karsten Mueller, Leonhard Schilbach, Henryk Barthel, Klaus Fassbender, Klaus Fliessbach, Johannes Kornhuber, Johannes Prudlo, Matthis Synofzik, Jens Wiltfang, Janine Diehl-Schmid, FTLD Consortium, Markus Otto, Juergen Dukart, Matthias L Schroeter
Publikováno v:
eLife, Vol 13 (2024)
Background: Aside to clinical changes, behavioral variant frontotemporal dementia (bvFTD) is characterized by progressive structural and functional alterations in frontal and temporal regions. We examined if there is a selective vulnerability of spec
Externí odkaz:
https://doaj.org/article/fde05e0927944a91a3fee2d7e54c5bed
Publikováno v:
Skeletal Muscle, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Background Spinal muscular atrophy (SMA) is a form of motor neuron disease affecting primarily children characterised by the loss of lower motor neurons (MNs). Breakdown of the neuromuscular junctions (NMJs) is an early pathological event in
Externí odkaz:
https://doaj.org/article/a5ea51d4e99f4e0ebeef8766169440e6
Akademický článek
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Autor:
Ohad Rechnitz, Dori Derdikman
Publikováno v:
eLife, Vol 12 (2023)
Blocking the activity of neurons in a region of the brain involved in memory leads to cell death, which could help explain the spatiotemporal disorientation observed in Alzheimer’s disease.
Externí odkaz:
https://doaj.org/article/421387f61e6546489d28b5f5043bbfb6
Autor:
Rong Zhao, Stacy D Grunke, Caleb A Wood, Gabriella A Perez, Melissa Comstock, Ming-Hua Li, Anand K Singh, Kyung-Won Park, Joanna L Jankowsky
Publikováno v:
eLife, Vol 11 (2022)
Neurodegenerative diseases are characterized by selective vulnerability of distinct cell populations; however, the cause for this specificity remains elusive. Here, we show that entorhinal cortex layer 2 (EC2) neurons are unusually vulnerable to prol
Externí odkaz:
https://doaj.org/article/3fdef3d02f1d43b89c3fd6523fe9841c
Akademický článek
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Publikováno v:
Neurobiology of Disease, Vol 173, Iss , Pp 105831- (2022)
Locus coeruleus (LC) is among the first brain areas to degenerate in Alzheimer's disease and Parkinson's disease; however, the underlying causes for the vulnerability of LC neurons are not well defined. Here we report a novel mechanism of degeneratio
Externí odkaz:
https://doaj.org/article/6431a3c8aa0a422f8c7d58e17ed741f8