Zobrazeno 1 - 10
of 377
pro vyhledávání: '"Selective progesterone receptor modulator"'
Autor:
Hugh S. Taylor, M.D., Liying Dong, M.D., Ph.D., Johanna Haikonen, M.D., Peter Oppelt, M.D., Karl Tamussino, M.D., Rene Wenzl, M.D., Ph.D., Thomas Faustmann, M.D., Esther Groettrup-Wolfers, M.D., Ph.D., Xiaowei Ren, Ph.D., Christian Seitz, M.D., Ph.D.
Publikováno v:
F&S Reports, Vol 5, Iss 2, Pp 189-196 (2024)
Objective: To evaluate the efficacy and safety of 2 doses of vilaprisan vs. placebo in participants with symptomatic endometriosis. Design: Multicenter, randomized, double-blind, placebo-controlled, parallel-group phase 2b trial (NCT03573336). The in
Externí odkaz:
https://doaj.org/article/d8f6b31dc0ed4dc1a5fa02650f0442ca
Autor:
Lucy HR Whitaker, Lee J Middleton, Lee Priest, Smita Odedra, Versha Cheed, Elaine P Nicholls, Alistair RW Williams, Neil Roberts, Clive E Stubbs, Konstantios Tryposkiadis, Hannah Bensoussane, Rohan Chodankar, Alison A Murray, Moira Nicol, Aleksandra O Tsolova, Kaiming Yin, Marcos Cruz, Hui Wei Leow, Lucy E Kershaw, Suzanne L McLenachan, Graham McKillop, Jane Walker, Scott I Semple, T Justin Clark, Mary Ann Lumsden, Dharani K Hapangama, Lucky Saraswat, Siladitya Bhattacharya, Paul Smith, Jane Daniels, Hilary OD Critchley
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 10, Iss 08 (2023)
Background Heavy menstrual bleeding affects one in four women and negatively impacts quality of life. The levonorgestrel-releasing intrauterine system is an effective long-term treatment but is discontinued by many due to unpredictable bleeding, or a
Externí odkaz:
https://doaj.org/article/38323e313da64fa9ae02ec319f5d5e89
Autor:
Lucy H.R. Whitaker, Lee J. Middleton, Jane P. Daniels, Alistair R.W. Williams, Lee Priest, Smita Odedra, Versha Cheed, Clive E. Stubbs, T. Justin Clark, Mary-Ann Lumsden, Dharani K. Hapangama, Siladitya Bhattacharya, Paul P. Smith, Elaine P. Nicholls, Neil Roberts, Scott I. Semple, Lucky Saraswat, Jane Walker, Rohan R. Chodankar, Hilary O.D. Critchley
Publikováno v:
EClinicalMedicine, Vol 60, Iss , Pp 101995- (2023)
Summary: Background: Heavy menstrual bleeding affects one in four women and negatively impacts quality of life. Ulipristal acetate is prescribed to treat symptoms associated with uterine fibroids. We compared the effectiveness of ulipristal acetate a
Externí odkaz:
https://doaj.org/article/51bd3cf24ebe439b895c5502d0e92246
Akademický článek
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Autor:
Ranka Kanda, Yuko Miyagawa, Osamu Wada-Hiraike, Haruko Hiraike, Kazunori Nagasaka, Eiji Ryo, Tomoyuki Fujii, Yutaka Osuga, Takuya Ayabe
Publikováno v:
Heliyon, Vol 8, Iss 1, Pp e08696- (2022)
Ulipristal acetate (UPA), a selective progesterone receptor modulator, is used for the treatment of uterine fibroids and selectively inhibits the proliferation and inflammation of leiomyoma cells. As few studies have focused on the molecular biologic
Externí odkaz:
https://doaj.org/article/b003ed4860a64c3e9678534696826daf
Autor:
Michał Ciebiera, Grzegorz Jakiel, Grażyna Nowicka, Antonio Simone Laganà, Fabio Ghezzi, Tomasz Łoziński, Cezary Wojtyła, Marta Włodarczyk
Publikováno v:
Archives of Medical Science, Vol 20, Iss 3, Pp 751-761 (2020)
Introduction Uterine fibroids (UFs) are benign tumors of the female reproductive system originating from the smooth muscle of the uterus. Currently, progesterone is known to play a key role in the differentiation of the myometrial tissue to form UFs
Externí odkaz:
https://doaj.org/article/9571bd57c5b54bf98a334657ed863e29
Autor:
I. O. Marinkin, L. A. Piven’, A. V. Volchek, D. A. Solyanikov, Yu. V. Zenina, E. S. Mihaylova, V. V. Omigov, S. V. Aidagulova
Publikováno v:
Сибирский научный медицинский журнал, Vol 40, Iss 1, Pp 39-44 (2020)
Aim of the study was to investigate the clinical features of reproductive age women with uterine body myoma and the production of vascular endothelial growth factor (VEGF) in the dominant myoma node and perifocal myometrium under the preoperative use
Externí odkaz:
https://doaj.org/article/2ef5c2ab87494662a4558f18dd904e49
Publikováno v:
Reproductive Medicine and Biology, Vol 19, Iss 1, Pp 65-74 (2020)
Abstract Purpose A multicenter, randomized, double‐blind, placebo‐controlled trial was conducted to evaluate the efficacy, safety, and appropriate dose of ulipristal acetate (UPA) in Japanese women with symptomatic uterine fibroids (UFs). Methods
Externí odkaz:
https://doaj.org/article/a30715a560db4d5eb1806c172c5864bc
Akademický článek
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