Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Selby de Klerk"'
Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones
Autor:
Alice C. Harnden, Owen A. Davis, Gary M. Box, Angela Hayes, Louise D. Johnson, Alan T. Henley, Alexis K. de Haven Brandon, Melanie Valenti, Kwai-Ming J. Cheung, Alfie Brennan, Rosemary Huckvale, Olivier A. Pierrat, Rachel Talbot, Michael D. Bright, Hafize Aysin Akpinar, Daniel S. J. Miller, Dalia Tarantino, Sharon Gowan, Selby de Klerk, Peter Craig McAndrew, Yann-Vaï Le Bihan, Mirco Meniconi, Rosemary Burke, Vladimir Kirkin, Rob L. M. van Montfort, Florence I. Raynaud, Olivia W. Rossanese, Benjamin R. Bellenie, Swen Hoelder
Publikováno v:
Journal of Medicinal Chemistry. 66:5892-5906
Autor:
Rosemary Huckvale, Alice C. Harnden, Kwai-Ming J. Cheung, Olivier A. Pierrat, Rachel Talbot, Gary M. Box, Alan T. Henley, Alexis K. de Haven Brandon, Albert E. Hallsworth, Michael D. Bright, Hafize Aysin Akpinar, Daniel S. J. Miller, Dalia Tarantino, Sharon Gowan, Angela Hayes, Emma A. Gunnell, Alfie Brennan, Owen A. Davis, Louise D. Johnson, Selby de Klerk, Craig McAndrew, Yann-Vaï Le Bihan, Mirco Meniconi, Rosemary Burke, Vladimir Kirkin, Rob L. M. van Montfort, Florence I. Raynaud, Olivia W. Rossanese, Benjamin R. Bellenie, Swen Hoelder
Publikováno v:
Journal of Medicinal Chemistry. 65:8191-8207
The transcriptional repressor BCL6 is an oncogenic driver found to be deregulated in lymphoid malignancies. Herein, we report the optimization of our previously reported benzimidazolone molecular glue-type degrader
Autor:
Hannah Woodward, Kwai-Ming J. Cheung, Paolo Innocenti, L. Johnson, Benjamin R. Bellenie, Florence I. Raynaud, Olivia W. Rossanese, Sharon Gowan, Vladimir Kirkin, Michael D. Bright, Alan T. Henley, Gavin W. Collie, Selby de Klerk, Olivier A. Pierrat, Rachel Talbot, Michael Carter, Yann-Vaï Le Bihan, Angela Hayes, Matthew Garth Lloyd, Manjuan Liu, Swen Hoelder, Rosemary Burke, Erald Shehu, Ana Varela, Matthew J. Rodrigues, Owen Alexander Davis, P. Craig McAndrew, Kartika N. Shetty, Gary Box, Rob L. M. van Montfort
Publikováno v:
Journal of Medicinal Chemistry. 63:4047-4068
Deregulation of the transcriptional repressor BCL6 enables tumorigenesis of germinal center B-cells, and hence BCL6 has been proposed as a therapeutic target for the treatment of diffuse large B-cell lymphoma (DLBCL). Herein we report the discovery o
Autor:
Benjamin R, Bellenie, Kwai-Ming J, Cheung, Ana, Varela, Olivier A, Pierrat, Gavin W, Collie, Gary M, Box, Michael D, Bright, Sharon, Gowan, Angela, Hayes, Matthew J, Rodrigues, Kartika N, Shetty, Michael, Carter, Owen A, Davis, Alan T, Henley, Paolo, Innocenti, Louise D, Johnson, Manjuan, Liu, Selby, de Klerk, Yann-Vaï, Le Bihan, Matthew G, Lloyd, P Craig, McAndrew, Erald, Shehu, Rachel, Talbot, Hannah L, Woodward, Rosemary, Burke, Vladimir, Kirkin, Rob L M, van Montfort, Florence I, Raynaud, Olivia W, Rossanese, Swen, Hoelder
Publikováno v:
Journal of Medicinal Chemistry
Deregulation of the transcriptional repressor BCL6 enables tumorigenesis of germinal center B-cells, and hence BCL6 has been proposed as a therapeutic target for the treatment of diffuse large B-cell lymphoma (DLBCL). Herein we report the discovery o