Immunostimulatory Profile of Cancer Cell Death by the AdV-Lumc007-Derived Oncolytic Virus ‘GoraVir’ in Cultured Pancreatic Cancer Cells

Autor: Selas T. F. Bots, Sanne L. Landman, Martijn J. W. E. Rabelink, Diana J. M. van den Wollenberg, Rob C. Hoeben

Publikováno v: Viruses, Vol 15, Iss 2, p 283 (2023)

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy which shows unparalleled therapeutic resistance. Oncolytic viruses have emerged as a new treatment approach and convey their antitumor activity through lysis of cancer cells. T

Externí odkaz: https://doaj.org/article/0a5f255e52f8489daa3b8340a31a7155

Reovirus mutant jin-3 exhibits lytic and immune-stimulatory effects in preclinical human prostate cancer models

Autor: Diana J. M. van den Wollenberg, Wouter R. Karthaus, Gabri van der Pluijm, Rob C. Hoeben, Geertje van der Horst, Tilly Aalders, Jack A. Schalken, Sigrun Erkens-Schulz, Nadine van Montfoort, Niven Mehra, Wytske M. van Weerden, Minke Smits, Maaike H. van der Mark, Arjanneke F. van de Merbel, Debra Stuurman, Selas T F Bots, Corrina M.A. de Ridder

Publikováno v: Cancer Gene Therapy, 29(6), 793-802. Nature Publishing Group
Cancer Gene Therapy, 29, 793-802
Cancer Gene Therapy, 29, 6, pp. 793-802
Cancer Gene Therapy. SPRINGERNATURE
Cancer Gene Therapy

Treatment of castration-resistant prostate cancer remains a challenging clinical problem. Despite the promising effects of immunotherapy in other solid cancers, prostate cancer has remained largely unresponsive. Oncolytic viruses represent a promisin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c8ddf89716b67750f4a53fec97b58bd
https://doi.org/10.1038/s41417-021-00360-2

Nonhuman Primate Adenoviruses of the Human Adenovirus B Species Are Potent and Broadly Acting Oncolytic Vector Candidates

Autor: Selas T F Bots, Steve J. Cramer, Martine L.M. Lamfers, Rob C. Hoeben, Gabri van der Pluijm, Vera Kemp, Diana J. M. van den Wollenberg, Marten Hornsveld

Publikováno v: Human Gene Therapy, 33(5-6), 275-289. Mary Ann Liebert Inc.

The use of human adenoviruses (hAds) as oncolytic agents has demonstrated considerable potential. However, their efficacy in clinical studies is generally moderate and often varies between patients. This may, in part, be attributable to variable pre-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989d4d2d8b69e73a17fb2566df9a4b1f
https://pure.eur.nl/en/publications/4c3df4ce-533a-4f72-9e7c-f4bc66c63eaa

Non-Human Primate-Derived Adenoviruses for Future Use as Oncolytic Agents?

Autor: Rob C. Hoeben, Selas T F Bots

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 4821, p 4821 (2020)
International Journal of Molecular Sciences, 21(14). MDPI

Non-human primate (NHP)-derived adenoviruses have formed a valuable alternative for the use of human adenoviruses in vaccine development and gene therapy strategies by virtue of the low seroprevalence of neutralizing immunity in the human population.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62da61c4e07c0245ec1c61ef0f803cea
http://europepmc.org/articles/PMC7404033