Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Selane L. King"'
Autor:
David J. Foltz, Roger G. Bookland, Fei Gu, Michael J. Janusz, Glen E. Mieling, Lily C. Hsieh, Todd M. Branch, Selane L. King, Matthew Pokross, Vikram S. Patel, Sean X. Peng, Staszek Pikul, Susan M. Garver, Matthew J. Laufersweiler, Biswanath De, Timothy R. Baker, Michael George Natchus, Neil Gregory Almstead
Publikováno v:
Journal of Medicinal Chemistry. 44:1060-1071
A series of carboxylic acids were prepared from a propargylglycine scaffold and tested for efficacy as matrix metalloproteinase (MMP) inhibitors. Detailed SAR for the series is reported for four enzymes within the MMP family. The inhibitors were typi
Autor:
Selane L. King, Todd M. Branch, Greg Ciszewski, Neil Gregory Almstead, Lily C. Hsieh, Laufersweiler Michael Christopher, Stanislaw Pikul, Michael J. Janusz, Yetunde Olabisi Taiwo, Michael George Natchus, Norman Eugene Ohler, Sean X. Peng, Biswanath De, Glen E. Mieling
Publikováno v:
Journal of medicinal chemistry. 44(16)
A novel series of carboxylic acids containing a substituted piperidine were synthesized and tested for inhibition of selected matrix metalloproteinases. Multiple analogues prepared based on this novel design were found to inhibit the target MMPs (MMP