Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Sela Mager"'
Autor:
Isabel Gonzalez, Carol Burdsal, Jennifer L. Sloan, Ann Sutherland, Sela Mager, Thurl E. Harris, Patrick M. Martin
Publikováno v:
Developmental Biology. 361(2):286-300
Uterine implantation is a critical element of mammalian reproduction and is a tightly and highly coordinated event. An intricate and reciprocal uterine-embryo dialog exists to synchronize uterine receptivity with the concomitant activation of the bla
Autor:
Pamela Moore-Martin, Anne V. Herdman, Malliga E. Ganapathy, Robert G. Martindale, Vadivel Ganapathy, Sela Mager, Naren Gupta, Puttur D. Prasad, Robert H. Podolsky, Sharad A. Ghamande
Publikováno v:
Gynecologic Oncology. 100:8-13
ATB(0,+) is an energy-coupled transporter for arginine and amino acid-based prodrugs. The objective of the study was to examine the expression of this transporter in cervical cancer.Specimens of normal ectocervical mucosa and cervical squamous cell c
Autor:
Robert G. Martindale, Naren Gupta, Anne V. Herdman, Vadivel Ganapathy, Seiji Miyauchi, Robert H. Podolsky, Katsuya Miyake, Malliga E. Ganapathy, Puttur D. Prasad, Sela Mager
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1741:215-223
ATB(0,+) (SLC6A14) is a Na(+)/Cl(-)-coupled arginine transporter expressed at low levels in normal colon. Arginine is an essential amino acid for tumor cells. Arginine is also the substrate for nitric oxide synthases (NOSs). Since arginine and argini
Publikováno v:
Molecular and Cellular Neuroscience. 26:406-417
GABAergic signaling in the CNS is terminated in part through uptake of GABA by GABA transporters. We used the yeast two-hybrid system to identify proteins that associate with the carboxy-terminus of the neuronal GABA transporter GAT1. We found an int
Publikováno v:
FEBS Letters. 426:174-178
Xenopus oocytes expressing the GABA transporter GAT1 were exposed to membrane-impermeant sulfhydryl reagents, resulting in decreased GABA transport current, decreased capacitive charge movements, and increased Na+ and Li+ leakage currents. Mutation o
Publikováno v:
Biophysical Journal. 71:3126-3135
Single-channel activities were observed in outside-out patches excised from oocytes expressing a mammalian 5-hydroxytryptamine (5-HT) transporter. Channel conductance was larger for a mutant in which asparagine177 of the third putative transmembrane
Publikováno v:
Neuron. 17:807-810
Neurotransmitter transporters thus have properties not imagined just a few years ago. Do any of these properties explain the puzzle posed at the beginning: a ubiquitously expressed molecule forms the target for a class of drugs that produce highly sp
Autor:
Sela Mager, Henry A. Lester, Nurit Kleinberger-Doron, Baruch I. Kanner, Gilmor I. Keshet, Norman Davidson
Publikováno v:
Europe PubMed Central
This study addresses the binding of ions and the permeation of substrates during function of the GABA transporter GAT1. GAT1 was expressed inXenopusoocytes and studied electrophysiologically as well as with [3H]GABA flux; GAT1 was also expressed in m
Autor:
Vladislav S. Markin, Sela Mager, Donald W. Hilgemann, Anatolii Kabakov, Gary A. Frazier, Chin Chih Lu
Publikováno v:
Proceedings of the National Academy of Sciences. 92:11220-11224
We have used capacitance measurements with a 1-microsecond voltage clamp technique to probe electrogenic ion-transporter interactions in giant excised membrane patches. The hydrophobic ion dipicrylamine was used to test model predictions for a simple
Autor:
Henry A. Lester, Sela Mager, Churl Min, Charles Chavkin, Beth J. Hoffman, Norman Davidson, Douglas J. Henry
Publikováno v:
Neuron. 12:845-859
We have studied permeation at a cloned rat 5-HT transporter expressed in Xenopus oocytes. [ 3 H)5-HT uptake and [ 125 I]RTI-55 binding yield a turnover rate of ∼1/s that does not depend on membrane potential. However, in voltage-clamp experiments,