Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sekoni D. Noel"'
Publikováno v:
Journal of the Endocrine Society
Reproduction is regulated by the gonadotropins, LH and FSH, which are synthesized and secreted by pituitary gonadotrophs in response to hypothalamic GnRH in a pulse frequency dependent manner. The gonadotroph decodes GnRH pulsatility via the GnRH rec
Autor:
Ursula B. Kaiser, Titilayo Muyide, Stephanie B. Seminara, Ana Paula Abreu, Jessica Carroll, Rona S. Carroll, Elena Gianetti, Sekoni D. Noel, Shuyun Xu, Ana Claudia Latronico, Cintia Tusset
Publikováno v:
The FASEB Journal. 28:1924-1937
Neurokinin B (NKB) and its G-protein-coupled receptor, NK3R, have been implicated in the neuroendocrine control of GnRH release; however, little is known about the structure-function relationship of this ligand-receptor pair. Moreover, loss-of-functi
Autor:
Francis de Zegher, Ursula B. Kaiser, Víctor M. Navarro, Joel N. Hirschhorn, Vinicius Nahime Brito, Berenice B. Mendonca, Delanie B. Macedo, Rona S. Carroll, Sekoni D. Noel, Priscilla Cukier, Priscila Gagliardi, Cristiane Kochi, Ana Claudia Latronico, Tânia Rodrigues, Andrew Dauber, Dominique Beckers, Iain R. Thompson, Ana Paula Abreu, John C. Gill, Luciana Ribeiro Montenegro, Carlos Alberto Longui
Publikováno v:
New England Journal of Medicine. 368:2467-2475
Background: The onset of puberty is first detected as an increase in pulsatile secretion of gonado-tropin-releasing hormone (GnRH). Early activation of the hypothalamic-pituitary-gonadal axis results in central precocious puberty. The timing of puber
Autor:
Ana Claudia Latronico, Berenice B. Mendonca, Ivo J.P. Arnhold, Sekoni D. Noel, Mario G. Santos, Shuyun Xu, Wendy Kuohung, A. P. Silveira-Neto, Mirta Gryngarten, Vinicius Nahime Brito, Suzy D.C. Bianco, Ana Paula Abreu, Ursula B. Kaiser, Leticia Ferreira Gontijo Silveira, M. E. Escobar
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 95:2276-2280
Context: Kisspeptin, encoded by the KISS1 gene, is a key stimulatory factor of GnRH secretion and puberty onset. Inactivating mutations of its receptor (KISS1R) cause isolated hypogonadotropic hypogonadism (IHH). A unique KISS1R-activating mutation w
Autor:
Ursula B. Kaiser, Vivian Lee, Anna Zhang, Le Min, Rona S. Carroll, Min Nie, Junping Wen, Sekoni D. Noel
Publikováno v:
Neuroendocrinology. 103(3-4)
Introduction: Many missense variants in G protein-coupled receptors (GPCRs) involved in the neuroendocrine regulation of reproduction have been identified by phenotype-driven or large-scale exome sequencing. Computational functional prediction analys
Autor:
John C. Gill, Ursula B. Kaiser, Shuyun Xu, Cecilia Martin, Cecilia Kwong, Víctor M. Navarro, Rona S. Carroll, Donald K. Clifton, Sekoni D. Noel, Robert A. Steiner
Publikováno v:
Endocrinology. 153(10)
At puberty, neurokinin B (NKB) and kisspeptin (Kiss1) may help to amplify GnRH secretion, but their precise roles remain ambiguous. We tested the hypothesis that NKB and Kiss1 are induced as a function of pubertal development, independently of the pr
Autor:
Ursula B. Kaiser, Sekoni D. Noel, Ana Paula Abreu, Shuyun Xu, Ana Claudia Latronico, Rona S. Carroll
Prokineticin receptors (PROKR) are G protein-coupled receptors (GPCR) that regulate diverse biological processes, including olfactory bulb neurogenesis and GnRH neuronal migration. Mutations in PROKR2 have been described in patients with varying degr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8c81ca428756f18f0a244a67a36664
https://europepmc.org/articles/PMC3404297/
https://europepmc.org/articles/PMC3404297/
Autor:
Sekoni D. Noel, Ursula B. Kaiser
In the past two decades, an increasing body of evidence has demonstrated that several G protein-coupled receptor (GPCR)-ligand pairs are critical for normal human reproductive development and function. Patients harboring genetic insults in either the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa72779a77d29ea83007e4d8c67f981
https://europepmc.org/articles/PMC3185177/
https://europepmc.org/articles/PMC3185177/
Autor:
Sekoni D Noel, Ana Paula Abreu, Shuyun Xu, Ana Claudia Latronico, Stephanie B Seminara, Rona Carroll, Ursula B Kaiser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9466ed244c4549c6a7b3864f75d5b638
https://doi.org/10.1210/endo-meetings.2011.part1.or6.or05-2
https://doi.org/10.1210/endo-meetings.2011.part1.or6.or05-2
Autor:
Ana Paula Abreu, Trevor Cole, Leticia Ferreira Gontijo Silveira, Elena Gianetti, Susan E. Stewart, Elaine Maria Frade Costa, John K. Amory, Virginia A. Hughes, Erol Bolu, Margaret de Castro, Ana Claudia Latronico, Cintia Tusset, Andrew A. Dwyer, Wiebke Arlt, William F. Crowley, Richard Quinton, Stephanie B. Seminara, Berenice B. Mendonca, Adriana Lofrano, Margaret G. Au, Jessica Carroll, Metin Ozata, Ericka B. Trarbach, Janet E. Hall, Ursula B. Kaiser, Sekoni D. Noel
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism; Vol 95
Context: Mutations in TAC3 and TACR3 (encoding neurokinin B and its receptor) have been identified in Turkish patients with idiopathic hypogonadotropic hypogonadism (IHH), but broader populations have not yet been tested and genotype-phenotype correl