Zobrazeno 1 - 10 of 46 pro vyhledávání: '"Sekar Natesampillai"'
1
Akademický článek
Single center, open label dose escalating trial evaluating once weekly oral ixazomib in ART-suppressed, HIV positive adults and effects on HIV reservoir size in vivo.
Autor: Nathan W Cummins, Jason Baker, Rana Chakraborty, Patrick G Dean, Enrique Garcia-Rivera, Ashton Krogman, Shaji Kumar, Yury V Kuzmichev, Gregory M Laird, Alan Landay, Mathias Lichterfeld, Maryam Mahmood, Jeffrey Martinson, Mark Maynes, Sekar Natesampillai, Vincent Rajkumar, Yelizaveta Rassadkina, Kristen D. Ritter, Christina G Rivera, Stacey A Rizza, Krupa Subramanian, Aaron J Tande, Elizabeth R Wonderlich, Jennifer A Whitaker, John Zeuli, Andrew D Badley
Publikováno v: EClinicalMedicine, Vol 42, Iss , Pp 101225- (2021)
Background: Achieving a functional or sterilizing cure for HIV will require identification of therapeutic interventions that reduce HIV reservoir size in infected individuals. Proteasome inhibitors, such as ixazomib, impact multiple aspects of HIV bi
Externí odkaz: https://doaj.org/article/9bcbc1806c0c4535bde930e29c873a95
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2
Akademický článek
Reactivating latent HIV with PKC agonists induces resistance to apoptosis and is associated with phosphorylation and activation of BCL2.
Autor: Andrea J French, Sekar Natesampillai, Ashton Krogman, Cristina Correia, Kevin L Peterson, Alecia Alto, Aswath P Chandrasekar, Anisha Misra, Ying Li, Scott H Kaufmann, Andrew D Badley, Nathan W Cummins
Publikováno v: PLoS Pathogens, Vol 16, Iss 10, p e1008906 (2020)
Eradication of HIV-1 by the "kick and kill" strategy requires reactivation of latent virus to cause death of infected cells by either HIV-induced or immune-mediated apoptosis. To date this strategy has been unsuccessful, possibly due to insufficient
Externí odkaz: https://doaj.org/article/43ec5f6e91a24ab2bbc1bd2c4e5d59c0
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3
Akademický článek
Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study.
Autor: Nathan W Cummins, Stacey Rizza, Mark R Litzow, Stephane Hua, Guinevere Q Lee, Kevin Einkauf, Tae-Wook Chun, Frank Rhame, Jason V Baker, Michael P Busch, Nicolas Chomont, Patrick G Dean, Rémi Fromentin, Ashley T Haase, Dylan Hampton, Sheila M Keating, Steven M Lada, Tzong-Hae Lee, Sekar Natesampillai, Douglas D Richman, Timothy W Schacker, Stephen Wietgrefe, Xu G Yu, Joseph D Yao, John Zeuli, Mathias Lichterfeld, Andrew D Badley
Publikováno v: PLoS Medicine, Vol 14, Iss 11, p e1002461 (2017)
BACKGROUND:Notwithstanding 1 documented case of HIV-1 cure following allogeneic stem cell transplantation (allo-SCT), several subsequent cases of allo-SCT in HIV-1 positive individuals have failed to cure HIV-1 infection. The aim of our study was to
Externí odkaz: https://doaj.org/article/6cb0f7ce4309430794213dddfb5bf122
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4
Akademický článek
Increasing procaspase 8 expression using repurposed drugs to induce HIV infected cell death in ex vivo patient cells.
Autor: Rahul Sampath, Nathan W Cummins, Sekar Natesampillai, Gary D Bren, Thomas D Chung, Jason Baker, Keith Henry, Amélie Pagliuzza, Andrew D Badley
Publikováno v: PLoS ONE, Vol 12, Iss 6, p e0179327 (2017)
HIV persists because a reservoir of latently infected CD4 T cells do not express viral proteins and are indistinguishable from uninfected cells. One approach to HIV cure suggests that reactivating HIV will activate cytotoxic pathways; yet when tested
Externí odkaz: https://doaj.org/article/fbe979067c1142899383a6144c7300a9
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5
Akademický článek
TRAIL dependent fratricidal killing of gp120 primed hepatocytes by HCV core expressing hepatocytes.
Autor: Stacey A Rizza, Kishore B Challagundla, Sekar Natesampillai, Gary D Bren, Jaromir Sykora, Henning Walczak, Andrew D Badley
Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27171 (2011)
The mechanism by which HIV and HCV cooperatively accelerate hepatocyte damage is not clearly understood; however, each virus affects the TRAIL: TRAIL-receptor system. We, therefore, questioned whether the independent effects of HCV and HIV combine to
Externí odkaz: https://doaj.org/article/9b38212406d244b0821b0672af30d909
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6
Akademický článek
Patients with discordant responses to antiretroviral therapy have impaired killing of HIV-infected T cells.
Autor: Sekar Natesampillai, Zilin Nie, Nathan W Cummins, Dirk Jochmans, Gary D Bren, Jonathan B Angel, Andrew D Badley
Publikováno v: PLoS Pathogens, Vol 6, Iss 11, p e1001213 (2010)
In medicine, understanding the pathophysiologic basis of exceptional circumstances has led to an enhanced understanding of biology. We have studied the circumstance of HIV-infected patients in whom antiretroviral therapy results in immunologic benefi
Externí odkaz: https://doaj.org/article/143cdd7991584c8080240d814977a14a
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9
The BCL-2 Inhibitor Venetoclax Augments Immune Effector Function Mediated by Fas Ligand, TRAIL, and Perforin/Granzyme B, Resulting in Reduced Plasma Viremia and Decreased HIV Reservoir Size during Acute HIV Infection in a Humanized Mouse Model
Autor: Aswath P. Chandrasekar, Nathan W. Cummins, Sekar Natesampillai, Anisha Misra, Alecia Alto, Greg Laird, Andrew D. Badley
Publikováno v: Journal of Virology. 96
This study is the first to examine the applicability of BCL-2 inhibition in the setting of active HIV infectionin vivo. Furthermore, this study demonstrates that venetoclax significantly enhances target cell killing induced by Fas ligand, TRAIL, and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0170897b9c2d9cca127dbfd3aae46a59
https://doi.org/10.1128/jvi.01730-22
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