Proteoliposomes – a system to study membrane proteins under buffer gradients by cryo-EM

Autor: Sejwal Kushal, Chami Mohamed, Baumgartner Paul, Kowal Julia, Müller Shirley A., Stahlberg Henning

Publikováno v: Nanotechnology Reviews, Vol 6, Iss 1, Pp 57-74 (2017)

Membrane proteins are vital to life and major therapeutic targets. Yet, understanding how they function is limited by a lack of structural information. In biological cells, membrane proteins reside in lipidic membranes and typically experience differ

Externí odkaz: https://doaj.org/article/00654cbd6ac04978a31415a0c2d7631d

Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes

Autor: Sejwal, Kushal, Chami, Mohamed, Rémigy, Hervé, Vancraenenbroeck, Renée, Sibran, William, Sütterlin, Rosmarie, Baumgartner, Paul, McLeod, Robert, Chartier-Harlin, Marie-Christine, Baekelandt, Veerle, Stahlberg, Henning, Taymans, Jean-Marc

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.8667. ⟨10.1038/s41598-017-09126-z⟩
Scientific Reports, 2017, 7 (1), pp.8667. ⟨10.1038/s41598-017-09126-z⟩
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

International audience; Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain protein implicated in the pathogenesis of both familial and sporadic Parkinson's disease (PD), and currently one of the most promising therapeutic targets for drug de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e2cc9a637c834c73b7163b590a51f5f1
https://pubmed.ncbi.nlm.nih.gov/28819229

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