Assessing seizure liability in vitro with voltage-sensitive dye imaging in mouse hippocampal slices

Autor: Yuichi Utsumi, Makiko Taketoshi, Michiko Miwa, Yoko Tominaga, Takashi Tominaga

Publikováno v: Frontiers in Cellular Neuroscience, Vol 17 (2023)

Non-clinical toxicology is a major cause of drug candidate attrition during development. In particular, drug-induced seizures are the most common finding in central nervous system (CNS) toxicity. Current safety pharmacology tests for assessing CNS fu

Externí odkaz: https://doaj.org/article/ed330bc31fcf4b6ab79a4db34d2f2869

The Role of Neuropathology Evaluation in the Nonclinical Assessment of Seizure Liability.

Autor: Sokolowski K; Denali Therapeutics, South San Francisco, California, USA., Liu J; Brown University, Providence, Rhode Island, USA., Delatte MS; Allucent, Cary, North Carolina, USA., Authier S; Charles River Laboratories, Laval, Québec, Canada., McMaster O; U.S. Food & Drug Administration, Silver Spring, Maryland, USA., Bolon B; GEMpath, Inc., Longmont, Colorado, USA.

Publikováno v: Toxicologic pathology [Toxicol Pathol] 2024 Dec 05, pp. 1926233241300065. Date of Electronic Publication: 2024 Dec 05.

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Gene Expression Profile as a Predictor of Seizure Liability.

Autor: Lipponen, Anssi^1,2 (AUTHOR), Kajevu, Natallie¹ (AUTHOR), Natunen, Teemu³ (AUTHOR), Ciszek, Robert¹ (AUTHOR), Puhakka, Noora¹ (AUTHOR), Hiltunen, Mikko³ (AUTHOR), Pitkänen, Asla¹ (AUTHOR) asla.pitkanen@uef.fi

Publikováno v: International Journal of Molecular Sciences. Feb2023, Vol. 24 Issue 4, p4116. 26p.

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