Sensitivity of rodents to SARS-CoV-2: Gerbils are susceptible to SARS-CoV-2, but guinea pigs are not

Autor: Kiyoko Iwatsuki-Horimoto, Maki Kiso, Mutsumi Ito, Seiya Yamayoshi, Yoshihiro Kawaoka

Publikováno v: npj Viruses, Vol 2, Iss 1, Pp 1-6 (2024)

Abstract Syrian hamster are sensitive to SARS-CoV-2 and widely used as an animal model of COVID-19. In contrast, mice are not readily infected by the ancestral strains of SARS-CoV-2 because of differences in their angiotensin-converting enzyme 2 (ACE

Externí odkaz: https://doaj.org/article/fc0535727ff147f4b99bfb662bb4ad00

Induction of IGHV3-53 public antibodies with broadly neutralising activity against SARS-CoV-2 including Omicron subvariants in a Delta breakthrough infection caseResearch in context

Autor: Takeo Kuwata, Yu Kaku, Shashwata Biswas, Kaho Matsumoto, Mikiko Shimizu, Yoko Kawanami, Ryuta Uraki, Kyo Okazaki, Rumi Minami, Yoji Nagasaki, Mami Nagashima, Isao Yoshida, Kenji Sadamasu, Kazuhisa Yoshimura, Mutsumi Ito, Maki Kiso, Seiya Yamayoshi, Masaki Imai, Terumasa Ikeda, Kei Sato, Mako Toyoda, Takamasa Ueno, Takako Inoue, Yasuhito Tanaka, Kanako Tarakado Kimura, Takao Hashiguchi, Yukihiko Sugita, Takeshi Noda, Hiroshi Morioka, Yoshihiro Kawaoka, Shuzo Matsushita, Jumpei Ito, Naoko Misawa, Arnon Plianchaisuk, Ziyi Guo, Alfredo Hina, Jr., Keiya Uriu, Kaoru Usui, Wilaiporn Saikruang, Spyridon Lytras, Ryo Yoshimura, Shusuke Kawakubo, Luca Nishimura, Yusuke Kosugi, Shigeru Fujita, Luo Chen, Jarel Elgin M. Tolentino, Lin Pan, Wenye Li, Maximilian Stanley Yo, Kio Horinaka, Mai Suganami, Adam P. Strange, Mika Chiba, Keiko Iida, Naomi Ohsumi, Kaho Okumura, Shiho Tanaka, Eiko Ogawa, Kyoko Yasuda, Tsuki Fukuda, Rina Osujo, Takasuke Fukuhara, Tomokazu Tamura, Rigel Suzuki, Saori Suzuki, Hayato Ito, Keita Matsuno, Hirofumi Sawa, Naganori Nao, Shinya Tanaka, Masumi Tsuda, Lei Wang, Yoshikata Oda, Zannatul Ferdous, Kenji Shishido, Keita Mizuma, Isshu Kojima, Jingshu Li, Tomoya Tsubo, Shuhei Tsujino, So Nakagawa, Kotaro Shirakawa, Akifumi Takaori-Kondo, Kayoko Nagata, Ryosuke Nomura, Yoshihito Horisawa, Yusuke Tashiro, Yugo Kawai, Kazuo Takayama, Rina Hashimoto, Sayaka Deguchi, Yukio Watanabe, Ayaka Sakamoto, Naoko Yasuhara, Tateki Suzuki, Kanako Kimura, Jiei Sasaki, Yukari Nakajima, Hisano Yajima, Yoshitaka Nakata, Hiroki Futatsusako, Takashi Irie, Ryoko Kawabata, Kaori Tabata, Hesham Nasser, Ryo Shimizu, MST Monira Begum, Michael Jonathan, Yuka Mugita, Otowa Takahashi, Kimiko Ichihara, Chihiro Motozono, Sharee Leong, Akatsuki Saito, Maya Shofa, Yuki Shibatani, Tomoko Nishiuchi, Hiroyuki Asakura, Jiri Zahradnik, Prokopios Andrikopoulos, Miguel Padilla-Blanco, Aditi Konar

Publikováno v: EBioMedicine, Vol 110, Iss , Pp 105439- (2024)

Summary: Background: Emergence of SARS-CoV-2 variants that escape neutralising antibodies hampers the development of vaccines and therapeutic antibodies against SARS-CoV-2. IGHV3-53/3-66-derived public antibodies, which are generally specific to the

Externí odkaz: https://doaj.org/article/e91f95c836a440f4825df3e5b712b6d7

Attenuation of A(H7N9) influenza virus infection in mice exposed to cigarette smoke

Autor: Satoshi Fukuyama, Jason E. Shoemaker, Dongming Zhao, Noriko Nagajima, Yuriko Tomita, Tadashi Maemura, Tiago Jose da Silva Lopes, Tokiko Watanabe, Seiya Yamayoshi, Hideki Hasegawa, Yoshihiro Kawaoka

Publikováno v: npj Viruses, Vol 2, Iss 1, Pp 1-8 (2024)

Abstract Influenza A(H7N9) virus showed high pathogenicity in humans when it emerged in 2013. Cigarette smoke (CS) causes pulmonary diseases including bronchitis, emphysema, and lung cancer. Although habitual smoking is thought to increase the risk o

Externí odkaz: https://doaj.org/article/d693870eecb54a2c9d517cf4699b35ae

An mRNA vaccine encoding the SARS-CoV-2 receptor-binding domain protects mice from various Omicron variants

Autor: Ryuta Uraki, Masaki Imai, Mutsumi Ito, Seiya Yamayoshi, Maki Kiso, Nao Jounai, Kazuki Miyaji, Kiyoko Iwatsuki-Horimoto, Fumihiko Takeshita, Yoshihiro Kawaoka

Publikováno v: npj Vaccines, Vol 9, Iss 1, Pp 1-10 (2024)

Abstract Here, we assessed the efficacy of a lipid nanoparticle-based mRNA vaccine candidate encoding the receptor-binding domain (LNP-mRNA-RBD) in mice. Mice immunized with LNP-mRNA-RBD based on the ancestral strain (ancestral-type LNP-mRNA-RBD) sho

Externí odkaz: https://doaj.org/article/427759ac641440db840a7f2931caa239

Antibody induction and immune response in nasal cavity by third dose of SARS-CoV-2 mRNA vaccination

Autor: Aya Ishizaka, Michiko Koga, Taketoshi Mizutani, Ryuta Uraki, Seiya Yamayoshi, Kiyoko Iwatsuki-Horimoto, Shinya Yamamoto, Masaki Imai, Takeya Tsutsumi, Yutaka Suzuki, Yoshihiro Kawaoka, Hiroshi Yotsuyanagi

Publikováno v: Virology Journal, Vol 20, Iss 1, Pp 1-12 (2023)

Abstract Background The mucosa serves as the first defence against pathogens and facilitates the surveillance and elimination of symbiotic bacteria by mucosal immunity. Recently, the mRNA vaccine against SARS-CoV-2 has been demonstrated to induce sec

Externí odkaz: https://doaj.org/article/6f1b2a1c7f034610aa818248bc6ecbb1