Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Seiya MIZUNO"'
Autor:
Dong-Joon Lee, Pyunggang Kim, Hyun-Yi Kim, Jinah Park, Seung-Jun Lee, Haein An, Jin Sun Heo, Min-Jung Lee, Hayato Ohshima, Seiya Mizuno, Satoru Takahashi, Han-Sung Jung, Seong-Jin Kim
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 7, Pp 1606-1619 (2024)
Abstract The asymmetric division of stem cells permits the maintenance of the cell population and differentiation for harmonious progress. Developing mouse incisors allows inspection of the role of the stem cell niche to provide specific insights int
Externí odkaz:
https://doaj.org/article/45eaee5e63e44ffbb153f7efdf8cf91e
Autor:
Daiki Wakasugi, Shinji Kondo, Farhana Ferdousi, Seiya Mizuno, Akira Yada, Kenichi Tominaga, Satoru Takahashi, Hiroko Isoda
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background Neuroinflammation is widely acknowledged as a characteristic feature of almost all neurological disorders and specifically in depression- and anxiety-like disorders. In recent years, there has been significant attention on natural
Externí odkaz:
https://doaj.org/article/aa38080127454026ba327a1978b6802f
Autor:
Ayumu Suzuki, Kousuke Uranishi, Masazumi Nishimoto, Yosuke Mizuno, Seiya Mizuno, Satoru Takahashi, Robert N. Eisenman, Akihiko Okuda
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Meiosis is a specialized type of cell division that occurs physiologically only in germ cells. We previously demonstrated that MYC-associated factor X (MAX) blocks the ectopic onset of meiosis in embryonic and germline stem cells in culture
Externí odkaz:
https://doaj.org/article/12ce24a12a9d4642b05b92a91f8d3572
Autor:
Sekar Arumsari, Septelia Inawati Wanandi, Resda Akhra Syahrani, Yukihide Watanabe, Seiya Mizuno
Publikováno v:
International Journal of Technology, Vol 15, Iss 2, Pp 353-363 (2024)
This study aimed to design specific and efficient single guide RNA (sgRNA) for CRISPR/Cas9 system to knockout human superoxide dismutase 2 (SOD2) in human breast cancer stem cells (BCSCs). To achieve this, two sgRNA targets were selected, located
Externí odkaz:
https://doaj.org/article/ef153eceb9ec4e2d9f7d362affc7daaa
Autor:
Kento Morimoto, Hayate Suzuki, Akihiro Kuno, Yoko Daitoku, Yoko Tanimoto, Kanako Kato, Kazuya Murata, Fumihiro Sugiyama, Seiya Mizuno
Publikováno v:
Open Biology, Vol 14, Iss 4 (2024)
Functional regions that regulate biological phenomena are interspersed throughout eukaryotic genomes. The most definitive approach for identifying such regions is to confirm the phenotype of cells or organisms in which specific regions have been muta
Externí odkaz:
https://doaj.org/article/45cd721f7963429daf872c1a56ec5bfc
Autor:
Xiangduo Kong, Nam Viet Nguyen, Yumeng Li, Jasmine Shaaban Sakr, Kate Williams, Sheila Sharifi, Jonathan Chau, Altay Bayrakci, Seiya Mizuno, Satoru Takahashi, Tohru Kiyono, Rabi Tawil, Ali Mortazavi, Kyoko Yokomori
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109357- (2024)
Summary: Facioscapulohumeral dystrophy (FSHD) is linked to contraction of D4Z4 repeats on chromosome 4q with SMCHD1 mutations acting as a disease modifier. D4Z4 heterochromatin disruption and abnormal upregulation of the transcription factor DUX4, en
Externí odkaz:
https://doaj.org/article/f69dcee0cc5f45588408be663a8a6bce
Autor:
Ryutaro Tamura, Yusuke Sabu, Tadahaya Mizuno, Seiya Mizuno, Satoshi Nakano, Mitsuyoshi Suzuki, Daiki Abukawa, Shunsaku Kaji, Yoshihiro Azuma, Ayano Inui, Tatsuya Okamoto, Seiichi Shimizu, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara, Satoru Takahashi, Hiroyuki Kusuhara, Yoh Zen, Tomohiro Ando, Hisamitsu Hayashi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Choline is an essential nutrient, and its deficiency causes steatohepatitis. Dietary phosphatidylcholine (PC) is digested into lysoPC (LPC), glycerophosphocholine, and choline in the intestinal lumen and is the primary source of systemic cho
Externí odkaz:
https://doaj.org/article/6e3497d067f34e50bfe570fb76233f5d
Autor:
Jihoon Ha, Minbeom Kim, Jin Seok Park, Yerin Lee, Jae Young Lee, Jin-Cheol Shin, Dongyeob Seo, Seong Shil Park, Jiyeon You, Su Myung Jung, Hye Young Kim, Seiya Mizuno, Satoru Takahashi, Seong-Jin Kim, Seok Hee Park
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113752- (2024)
Summary: We here demonstrate that SERTAD1 is an adaptor protein responsible for the regulation of lysine 63 (K63)-linked NLRP3 polyubiquitination by the Cullin1 E3 ubiquitin ligase upon inflammasome activation. SERTAD1 specifically binds to NLRP3 but
Externí odkaz:
https://doaj.org/article/53525859901a42a281998e012e4391f2
Autor:
Tomohiro Tamari, Yoshihisa Ikeda, Kento Morimoto, Keiko Kobayashi, Saori Mizuno-Iijima, Shinya Ayabe, Akihiro Kuno, Seiya Mizuno, Atsushi Yoshiki
Publikováno v:
Biology Open, Vol 12, Iss 9 (2023)
Externí odkaz:
https://doaj.org/article/df15e47e773446f9b99e32c76716beb4
Autor:
Motohiro Sekiya, Yang Ma, Kenta Kainoh, Kenji Saito, Daichi Yamazaki, Tomomi Tsuyuzaki, Wanpei Chen, Putu Indah Paramita Adi Putri, Hiroshi Ohno, Takafumi Miyamoto, Yoshinori Takeuchi, Yuki Murayama, Yoko Sugano, Yoshinori Osaki, Hitoshi Iwasaki, Naoya Yahagi, Hiroaki Suzuki, Kaori Motomura, Takashi Matsuzaka, Kazuya Murata, Seiya Mizuno, Satoru Takahashi, Hitoshi Shimano
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112914- (2023)
Summary: The adaptive increase in insulin secretion in early stages of obesity serves as a safeguard mechanism to maintain glucose homeostasis that cannot be sustained, and the eventual decompensation of β cells is a key event in the pathogenesis of
Externí odkaz:
https://doaj.org/article/3b0c9249a97544358bb7aad112559fb6