Výsledky vyhledávání - "Seiya Horisawa"

Pharmacological Profile of SMP-797, a Novel Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibitor with Inducible Effect on the Expression of Low-Density Lipoprotein Receptor

Autor: Masami Muraoka, Takeshi Nishimura, Kouichi Kino, Tsuyoshi Noguchi, Katsuhisa Ioriya, Naohito Ohashi, Seiya Horisawa

Publikováno v: Journal of Cardiovascular Pharmacology. 47:322-329

We investigated the pharmacological profile of SMP-797, a novel hypocholesterolemic agent. SMP-797 showed inhibitory effects on acyl-coenzyme A: cholesterol acyltransferase (ACAT) activities in various microsomes and in human cell lines, and hypochol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2f61d5e79695b4b348102c6c4f2296
https://doi.org/10.1097/01.fjc.0000205498.67895.7e

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Protective Effects of SM-20302, an Orally Active GPIIb/IIIa Antagonist, in an ADP/Epinephrine-Induced Guinea Pig Model of Transient Cerebral Ischemia

Autor: Seiya Horisawa, Teruo Sakurama, Munekiyo Kaneko

Publikováno v: Thrombosis Research. 101:119-126

The potential benefits of SM-20302, (2 S )-3-(3-(4-amidinobenzoylamino)propanoylamino)-2-(4-ethyl)benzensulfonylaminopropionic acid hydrochloride, a nonpeptide GPIIb/IIIa receptor antagonist, were compared with those of aspirin and ticlopidine in a t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e64d0fd89c9ef335407bacfb46c887
https://doi.org/10.1016/s0049-3848(00)00378-9

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SM-20302, a nonpeptide GPIIb/IIIa receptor antagonist, exhibits a wide therapeutic window in a newly developed hemorrhage model in mice

Autor: Seiya Horisawa, Munekiyo Kaneko, Teruo Sakurama

Publikováno v: Thrombosis and haemostasis. 82(6)

SummaryWe have developed a gastrointestinal hemorrhage model in mice and thereby assessed the potential risk of bleeding following administration of SM-20302, a nonpeptide GPIIb/IIIa receptor antagonist. First, SM-20302 selectively inhibited the inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9eb6173b5478e0510ac693e17b3a46
https://pubmed.ncbi.nlm.nih.gov/10613664

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