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Inhibition of nitric oxide-stimulated vasorelaxation by carbon monoxide-releasing molecules

Autor: Ana R. Marques, Giuseppe Cirino, Annie Beuve, Mariarosaria Bucci, Ciro Coletta, Csaba Szabó, Carlos C. Romão, Valentina Vellecco, João Seixas, Andreas Papapetropoulos, Ana M. L. Gonçalves, Bruno Guerreiro, Antonia Marazioti, Padmamalini Baskaran

Objective— Carbon monoxide (CO) is a weak soluble guanylyl cyclase stimulator, leading to transient increases in cGMP and vasodilation. The aim of the present work was to measure the effect of CO-releasing molecules (CORMs) on the cGMP/nitric oxide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bffc7e6aa1564940b73bd83c0664dcd9
http://hdl.handle.net/11588/573385

Ibrutinib Inhibits BMX-Dependent Endothelial VCAM-1 Expression In Vitro and Pro-Atherosclerotic Endothelial Activation and Platelet Adhesion In Vivo .

Autor: Kohs TCL; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239 USA., Olson SR; Division of Hematology & Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR USA., Pang J; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239 USA., Jordan KR; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239 USA., Zheng TJ; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239 USA., Xie A; Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR USA., Hodovan J; Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR USA., Muller M; Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR USA., McArthur C; Oregon National Primate Research Center, Oregon Health & Science University, Portland, OR USA., Johnson J; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239 USA., Sousa BB; Instituto de Medicina Molecular, João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal., Wallisch M; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239 USA.; Aronora, Inc., Portland, OR USA., Kievit P; Oregon National Primate Research Center, Oregon Health & Science University, Portland, OR USA., Aslan JE; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239 USA.; Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR USA., Seixas JD; Instituto de Medicina Molecular, João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal., Bernardes GJL; Instituto de Medicina Molecular, João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Hinds MT; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239 USA., Lindner JR; Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR USA.; Oregon National Primate Research Center, Oregon Health & Science University, Portland, OR USA., McCarty OJT; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239 USA.; Division of Hematology & Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR USA., Puy C; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239 USA.; Division of Hematology & Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR USA., Shatzel JJ; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239 USA.; Division of Hematology & Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR USA.

Publikováno v: Cellular and molecular bioengineering [Cell Mol Bioeng] 2022 Apr 18; Vol. 15 (3), pp. 231-243. Date of Electronic Publication: 2022 Apr 18 (Print Publication: 2022).

Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors.

Autor: Seixas JD; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa Avenida Professor Egas Moniz 1649-028 Lisboa Portugal gbernardes@medicina.ulisboa.pt joaoseixas@medicina.ulisboa.pt., Sousa BB; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa Avenida Professor Egas Moniz 1649-028 Lisboa Portugal gbernardes@medicina.ulisboa.pt joaoseixas@medicina.ulisboa.pt.; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa Av. da República EAN 2780-157 Oeiras Portugal., Marques MC; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa Avenida Professor Egas Moniz 1649-028 Lisboa Portugal gbernardes@medicina.ulisboa.pt joaoseixas@medicina.ulisboa.pt., Guerreiro A; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa Avenida Professor Egas Moniz 1649-028 Lisboa Portugal gbernardes@medicina.ulisboa.pt joaoseixas@medicina.ulisboa.pt., Traquete R; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa Avenida Professor Egas Moniz 1649-028 Lisboa Portugal gbernardes@medicina.ulisboa.pt joaoseixas@medicina.ulisboa.pt., Rodrigues T; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa Avenida Professor Egas Moniz 1649-028 Lisboa Portugal gbernardes@medicina.ulisboa.pt joaoseixas@medicina.ulisboa.pt., Albuquerque IS; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa Avenida Professor Egas Moniz 1649-028 Lisboa Portugal gbernardes@medicina.ulisboa.pt joaoseixas@medicina.ulisboa.pt., Sousa MFQ; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa Av. da República EAN 2780-157 Oeiras Portugal.; IBET - Instituto de Biologia Experimental e Tecnológica Av. da República EAN 2780-157 Oeiras Portugal., Lemos AR; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa Av. da República EAN 2780-157 Oeiras Portugal.; IBET - Instituto de Biologia Experimental e Tecnológica Av. da República EAN 2780-157 Oeiras Portugal., Sousa PMF; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa Av. da República EAN 2780-157 Oeiras Portugal.; IBET - Instituto de Biologia Experimental e Tecnológica Av. da República EAN 2780-157 Oeiras Portugal., Bandeiras TM; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa Av. da República EAN 2780-157 Oeiras Portugal.; IBET - Instituto de Biologia Experimental e Tecnológica Av. da República EAN 2780-157 Oeiras Portugal., Wu D; Department of Chemistry, University of Oxford South Parks Road Oxford OX1 3QZ UK., Doyle SK; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology Cambridge MA 02142 USA., Robinson CV; Department of Chemistry, University of Oxford South Parks Road Oxford OX1 3QZ UK., Koehler AN; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology Cambridge MA 02142 USA., Corzana F; Departamento de Química, Universidad de La Rioja, Centro de Investigación en Síntesis Química 26006 Logroño Spain., Matias PM; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa Av. da República EAN 2780-157 Oeiras Portugal.; IBET - Instituto de Biologia Experimental e Tecnológica Av. da República EAN 2780-157 Oeiras Portugal., Bernardes GJL; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa Avenida Professor Egas Moniz 1649-028 Lisboa Portugal gbernardes@medicina.ulisboa.pt joaoseixas@medicina.ulisboa.pt.; Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK gb453@cam.ac.uk.

Publikováno v: RSC chemical biology [RSC Chem Biol] 2020 Aug 28; Vol. 1 (4), pp. 251-262. Date of Electronic Publication: 2020 Aug 28 (Print Publication: 2020).

Enhanced Permeability and Binding Activity of Isobutylene-Grafted Peptides.

Autor: Sun S; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Compañón I; Departamento de Química, Centro de Investigación en Síntesis Química, Universidad de La Rioja, Madre de Dios, 53, 26006, Logroño, Spain., Martínez-Sáez N; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Seixas JD; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisboa, Portugal., Boutureira O; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Corzana F; Departamento de Química, Centro de Investigación en Síntesis Química, Universidad de La Rioja, Madre de Dios, 53, 26006, Logroño, Spain., Bernardes GJL; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisboa, Portugal.

Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2018 Jan 04; Vol. 19 (1), pp. 48-52. Date of Electronic Publication: 2017 Nov 22.