Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Seiu IIDA"'
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Pharmacokinetic Studies of 3-Methyl-1-phenyl-2-pyrazolin-5-one(MCI-186) in Rats. (1). Blood and Plasma Levels, Distribution, Metabolism and Excretion after a Single Intravenous Administration
Autor: Seiu Iida, Katsuyoshi Masaki, Teiko Komatsu, Hiroshi Nakai, Keiko Nakai, Rie Obata
Publikováno v: Drug Metabolism and Pharmacokinetics. 11:463-480
In order to clarify the metabolic fate of MCI-186 in rats, blood and plasma levels, distribution, metabolism and excretion were investigated after a single intravenous administration of 14C-MCI-186 to male and female rats. 1) After intravenous admini
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70f0e1d4af337915ea720c03d709268c
https://doi.org/10.2133/dmpk.11.463
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2
Pharmacokinetic Studies of 3-Methyl-1-phenyl-2-pyrazolin-5-one(MCI-186) in rats. (2). Blood and Plasma Levels, Distribution, Metabolism, Excretion and Accumulation during and after Repeated Intravenous Administration
Autor: Seiu Iida, Teiko Komatsu, Rie Obata, Hiroshi Nakai, Keiko Nakai, Katsuyoshi Masaki
Publikováno v: Drug Metabolism and Pharmacokinetics. 11:481-491
During and after a single or repeated intravenous administration of 14C-MCI-186 (2 mg/kg/day) for 7, 14 and 21 days to male rats, blood and plasma levels, distribution, metabolism, excretion and accumulation of MCI-186 were investigated. 1) Tissue le
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12bdc6f9f1da02fe1f54b858dc483b8e
https://doi.org/10.2133/dmpk.11.481
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5
Pharmacokinetic Studies of 3-Methyl-1-phenyl-2-pyrazolin-5-one(MCI-186): Metabolism in Rats, Dogs and Human
Autor: Yasuhiro Morinaka, Kazutoshi Watanabe, Yasuo Takamatsu, Teiko Komatsu, Masaki Shinoda, Hiroshi Nakai, Seiu Iida
Publikováno v: Drug Metabolism and Pharmacokinetics. 11:451-462
In order to clalify the species difference in metabolism of MCI-186, the identification of metabolites, urinary excretion rates of unchanged MCI-186 and its metabolites, and in vitro metabolism were investigated in rats, dogs and human. 1. Main metab
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47295b7b886192846fe36769d7813b0a
https://doi.org/10.2133/dmpk.11.451
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6
Studies on the Metabolic Fate of (.+-.)-2-(Dimethylamino)-1-((o-(m-methoxyphenethyl)-phenoxy)methyl)ethyl hydrogen siccinate hydrochloride (MCI-9042). (II). Absorption, Distribution, Metabolism and Excretion after a Single Administration to Rats
Autor: Setsuko Enjouji, Tomio Inokuchi, Hiroshi Nakai, Seiu Iida, Teiko Komatsu
Publikováno v: Drug Metabolism and Pharmacokinetics. 6:377-398
The absorption, metabolism and excretion of MCI-9042 were investigated in male and female dogs after oral (20mg/kg) or intravenous (1 mg/kg) administration of 14C-MCI-9042.1. After oral administration of 14C-MCI-9042 to male and female dogs, both the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7520416952080138e87fda3df03a1b9
https://doi.org/10.2133/dmpk.6.377
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9
Studies on the Metabolic Fate of (.+-.)-2-(Dimethylamino)-1-((o-(m-methoxyphenethyl)-phenoxy)methyl)ethyl hydrogen succinate hydrochloride (MCI-9042). (III). Absorption, Distribution, Metabolism, Excretion, Accumulation and Effect on the Hepatic Drug-Metabolizing Enzyme Activities after Repeated Oral Administration to Rats
Autor: Jun Tatsuno, Kazuyoshi Suzuki, Tomio Inokuchi, Seiu Iida, Teiko Komatsu
Publikováno v: Drug Metabolism and Pharmacokinetics. 6:399-414
The absorption, distribution, metabolism, excretion and accumulation of MCI-9042 were investigated after repeated oral administration of 14C-MCI-9042 (20mg/kg/day) to male rats for 21 days. The effect of MCI-9042 on the hepatic drug-metabolizing enzy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d21690d127ebcee1a1f8e9cbeb2987f9
https://doi.org/10.2133/dmpk.6.399
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