Výsledky vyhledávání - "Seisho Kinoshita"

Akademický článek

Development of novel humanized VHH synthetic libraries based on physicochemical analyses

Autor: Makoto Nakakido, Seisho Kinoshita, Kouhei Tsumoto

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract Due to the high affinity and specificity of antibodies toward antigens, various antibody-based applications have been developed. Recently, variable antigen-binding domains of heavy-chain antibodies (VHH) have become an attractive alternative

Externí odkaz: https://doaj.org/article/d9dd5118d0fd48ff9dc17a32fa2cff91

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Molecular basis for thermal stability and affinity in a VHH: Contribution of the framework region and its influence in the conformation of the CDR3

Autor: Seisho Kinoshita, Makoto Nakakido, Chinatsu Mori, Daisuke Kuroda, Jose M.M. Caaveiro, Kouhei Tsumoto

Publikováno v: Protein science : a publication of the Protein Society. 31(11)

The camelid single domain antibody, referred to VHH or Nanobody, is considered a versatile tool for various biotechnological and clinical applications because of its favorable biophysical properties. To take advantage of these characteristics and for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb291e1356f4794ce192faa3469f4b9d
https://pubmed.ncbi.nlm.nih.gov/36153698

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