Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Seishi, Katsumata"'
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 376:250-260
ONO-4641 is a second-generation sphingosine 1-phosphate (S1P) receptor modulator that exhibits selectivity for S1P receptors 1 and 5. Treatment with ONO-4641 leads to a reduction in magnetic resonance imaging disease measures in patients with relapsi
Autor:
Bin Ji, Shigeto Yamawaki, Seishi Katsumata, Koji Hosokawa, Nobuaki Shime, Takashi Kitajima, Kazuya Kikutani, Shuji Fukuda, Tetsuya Suhara, Hiroshi Giga, Hidenori Aizawa, Miho Matsumata
Publikováno v:
Shock.
Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction associated with sepsis. The development of an effective strategy for early diagnosis and therapeutic intervention is essential for the prevention of poor prognosis of SAE. Transloc
Autor:
Tetsuya Yasuhiro, Masato Higashino, Keisuke Hazama, Scott A. Maidment, Miki Nakanishi, Nobuto Nakanishi, Mark S. Chambers, Gary Clark, Seishi Katsumata, Soichi Kawaharada, Shuji Kaneko, Arwel Lewis
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 366:58-65
GABAA receptors containing α5 subunits (GABAAα5) are highly expressed in the hippocampus and negatively involved in memory processing, as shown by the fact that GABAAα5–deficient mice show higher hippocampus-dependent performance than wild-type
Autor:
Seishi Katsumata
Publikováno v:
Folia Pharmacologica Japonica. 149:148-153
Autor:
Seishi Katsumata, Noriko Morimoto, Tomohiro Niwa, Katsukuni Mitsui, Hiroyuki Ohba, Hideo Tsukada, Yoshiyuki Yamaura
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 360:457-465
We have previously shown that ONO-2952, a novel 18-kDa translocator protein (TSPO) antagonist, inhibits stress-induced accumulation of neurosteroids and noradrenaline release in the rat brain and alleviates the subsequent symptomatic responses with a
Autor:
Koji Shinozaki, Tatsuya Komagata, Hiroki Okada, Takuya Nishio, Seishi Katsumata, Akiharu Ishida, Hirotaka Tanaka
Publikováno v:
Journal of the Endocrine Society
Purpose: The verification of efficacy of new drug candidates in primate models may address the translational gap between non-clinical and clinical studies and support the prediction of efficacy in humans. Given this, and to support the evaluation of
Autor:
Hiroyuki Iida, Hirotaka Tanaka, Tatsuya Komagata, Shinichi Neki, Akiharu Ishida, Hiroki Okada, Takeshi Sawada, Seishi Katsumata, Koji Shinozaki
Publikováno v:
Journal of the Endocrine Society
Somatostatin analogues (SSAs) are indicated for use in acromegaly and gastroenteropancreatic neuroendocrine tumors (GEP NETs). However, SSAs are administered as injections which can be a challenge for patients and healthcare providers. ONO-5788 is a
Autor:
Masaru Sakai, Tetsuya Hagio, Tetsuya Yasuhiro, Sho Kouyama, Hidenori Miyata, Yasuo Yonetomi, Shinya Sakimoto, Takehiro Ono, Seishi Katsumata, Takashi Sasamura
Publikováno v:
Stroke. 50
Introduction: Factor XI (FXI) is an important component in the intrinsic pathway of the coagulation system. FXI antisense oligonucleotide achieves antithrombotic efficacy with a low risk of bleeding in preclinical and early clinical studies. ONO-8610
Autor:
Hiroshi Giga, Bin Ji, Kazuya Kikutani, Shuji Fukuda, Takashi Kitajima, Seishi Katsumata, Miho Matsumata, Tetsuya Suhara, Shigeto Yamawaki, Nobuaki Shime, Koji Hosokawa, Hidenori Aizawa
Publikováno v:
Shock; Jul2021, Vol. 56 Issue 1, p142-149, 8p
Autor:
Kanako Nozaki, Seishi Katsumata, Takahiro A. Kato, Yosuke Yamawaki, Masahiro Ohgidani, Shigeto Yamawaki, Takashi Kitajima, Ezgi Hatice Sahin, Hidenori Aizawa, Hikaru Ito
Publikováno v:
Neuropharmacology. 162:107835
In preclinical models, it has been reported that social defeat stress activates microglial cells in the CNS. Translocator protein 18 kDa (TSPO) is a mitochondrial protein expressed on microglia in the CNS that has been proposed to be a useful biomark