GSE1 links the HDAC1/CoREST co-repressor complex to DNA damage.

Autor: Vcelkova T; Center for Anatomy and Cell Biology, Medical University of Vienna, 1090 Vienna, Austria., Reiter W; Mass Spectrometry Facility, Max Perutz Labs, Vienna BioCenter, 1030 Vienna, Austria.; Department of Biochemistry and Cell Biology, Max Perutz Labs, University of Vienna, Vienna BioCenter, Dr. Bohr-Gasse 9, 1030 Vienna, Austria., Zylka M; Center for Anatomy and Cell Biology, Medical University of Vienna, 1090 Vienna, Austria., Hollenstein DM; Mass Spectrometry Facility, Max Perutz Labs, Vienna BioCenter, 1030 Vienna, Austria.; Department of Biochemistry and Cell Biology, Max Perutz Labs, University of Vienna, Vienna BioCenter, Dr. Bohr-Gasse 9, 1030 Vienna, Austria., Schuckert S; Center for Anatomy and Cell Biology, Medical University of Vienna, 1090 Vienna, Austria., Hartl M; Mass Spectrometry Facility, Max Perutz Labs, Vienna BioCenter, 1030 Vienna, Austria.; Department of Biochemistry and Cell Biology, Max Perutz Labs, University of Vienna, Vienna BioCenter, Dr. Bohr-Gasse 9, 1030 Vienna, Austria., Seiser C; Center for Anatomy and Cell Biology, Medical University of Vienna, 1090 Vienna, Austria.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2023 Nov 27; Vol. 51 (21), pp. 11748-11769.

DNA hypomethylation leads to cGAS-induced autoinflammation in the epidermis.

Autor: Beck MA; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Fischer H; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Grabner LM; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Groffics T; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Winter M; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Tangermann S; Unit of Laboratory Animal Pathology, University of Veterinary Medicine, Vienna, Austria., Meischel T; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Zaussinger-Haas B; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Wagner P; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Fischer C; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Folie C; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria.; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Salzburg, Austria., Arand J; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Schöfer C; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Ramsahoye B; MRC Institute of Genetics & Molecular Medicine, Centre for Genomic & Experimental Medicine, University of Edinburgh, Edinburgh, UK., Lagger S; Unit of Laboratory Animal Pathology, University of Veterinary Medicine, Vienna, Austria., Machat G; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Eisenwort G; Institute of Immunology, Medical University of Vienna, Vienna, Austria., Schneider S; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Podhornik A; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Kothmayer M; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Reichart U; VetCORE - Facility for Research, University of Veterinary Medicine Vienna, Vienna, Austria., Glösmann M; VetCORE - Facility for Research, University of Veterinary Medicine Vienna, Vienna, Austria., Tamir I; Campus Science Support Facilities GmbH, Vienna, Austria., Mildner M; Research Division of Biology and Pathobiology of the Skin, Medical University of Vienna, Vienna, Austria., Sheibani-Tezerji R; Ludwig Boltzmann Institute Applied Diagnostics, Vienna, Austria., Kenner L; Unit of Laboratory Animal Pathology, University of Veterinary Medicine, Vienna, Austria.; Christian Doppler Laboratory for Applied Metabolomics, Vienna, Austria.; Department of Pathology, Medical University of Vienna, Vienna, Austria.; CBmed GmbH - Center for Biomarker Research in Medicine, Graz, Austria., Petzelbauer P; Skin and Endothelium Research Division, Department of Dermatology, Medical University of Vienna, Vienna, Austria., Egger G; Ludwig Boltzmann Institute Applied Diagnostics, Vienna, Austria.; Department of Pathology, Medical University of Vienna, Vienna, Austria., Sibilia M; Department of Medicine I, Comprehensive Cancer Center, Institute of Cancer Research, Medical University of Vienna), Vienna, Austria., Ablasser A; Global Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland., Seiser C; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria.

Publikováno v: The EMBO journal [EMBO J] 2021 Nov 15; Vol. 40 (22), pp. e108234. Date of Electronic Publication: 2021 Sep 29.

Histone deacetylase 1 controls CD4 ⁺ T cell trafficking in autoinflammatory diseases.

Autor: Hamminger P; Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. Electronic address: patricia.hamminger@meduniwien.ac.at., Marchetti L; Theodor Kocher Institute, University of Bern, Bern, Switzerland. Electronic address: lmarchetti90@gmail.com., Preglej T; Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria; Current Address: Division of Rheumatology, Medical University of Vienna, Vienna, Austria. Electronic address: teresa.preglej@meduniwien.ac.at., Platzer R; Institute of Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. Electronic address: rene.platzer@meduniwien.ac.at., Zhu C; Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria. Electronic address: ci.zhu@meduniwien.ac.at., Kamnev A; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria; Department of Dermatology, Medical University of Vienna, Vienna, Austria. Electronic address: anton.kamnev@rud.lbg.ac.at., Rica R; Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. Electronic address: ramona.rica@meduniwien.ac.at., Stolz V; Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. Electronic address: valentina.stolz@meduniwien.ac.at., Sandner L; Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. Electronic address: lisa.sandner@meduniwien.ac.at., Alteneder M; Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. Electronic address: marlis.alteneder@meduniwien.ac.at., Kaba E; Theodor Kocher Institute, University of Bern, Bern, Switzerland. Electronic address: elisa.kaba@tki.unibe.ch., Waltenberger D; Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. Electronic address: darina.waltenberger@meduniwien.ac.at., Huppa JB; Institute of Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. Electronic address: johannes.huppa@meduniwien.ac.at., Trauner M; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria. Electronic address: michael.trauner@meduniwien.ac.at., Bock C; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria; Institute of Artificial Intelligence and Decision Support, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria. Electronic address: cbock@cemm.oeaw.ac.at., Lyck R; Theodor Kocher Institute, University of Bern, Bern, Switzerland. Electronic address: ruth.lyck@tki.unibe.ch., Bauer J; Department of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Austria. Electronic address: jan.bauer@meduniwien.ac.at., Dupré L; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria; Department of Dermatology, Medical University of Vienna, Vienna, Austria; Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM UMR1291, CNRS UMR5051, Toulouse III Paul Sabatier University, Toulouse, France. Electronic address: loic.dupre@rud.lbg.ac.at., Seiser C; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria. Electronic address: christian.seiser@univie.ac.at., Boucheron N; Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. Electronic address: nicole.boucheron@meduniwien.ac.at., Engelhardt B; Theodor Kocher Institute, University of Bern, Bern, Switzerland. Electronic address: britta.engelhardt@tki.unibe.ch., Ellmeier W; Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. Electronic address: wilfried.ellmeier@meduniwien.ac.at.

Publikováno v: Journal of autoimmunity [J Autoimmun] 2021 May; Vol. 119, pp. 102610. Date of Electronic Publication: 2021 Feb 20.

Targeting foam cell formation in inflammatory brain diseases by the histone modifier MS-275.

Autor: Zierfuss B; Department of Pathobiology of the Nervous System, Centre for Brain Research, Medical University of Vienna, Vienna, 1090, Austria., Weinhofer I; Department of Pathobiology of the Nervous System, Centre for Brain Research, Medical University of Vienna, Vienna, 1090, Austria., Buda A; Department of Pathobiology of the Nervous System, Centre for Brain Research, Medical University of Vienna, Vienna, 1090, Austria., Popitsch N; Institute of Molecular Biotechnology, Vienna, 1030, Austria., Hess L; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, 1090, Austria., Moos V; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, 1090, Austria., Hametner S; Department of Neuropathology and Neurochemistry, Medical University of Vienna, Vienna, 1090, Austria., Kemp S; Laboratory Genetic Metabolic Diseases, Amsterdam UMC, Amsterdam Gastroenterology & Metabolism, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, 1105AZ, The Netherlands., Köhler W; Department of Neurology, University of Leipzig Medical Centre, Leukodystrophy Clinic, Leipzig, 04103, Germany., Forss-Petter S; Department of Pathobiology of the Nervous System, Centre for Brain Research, Medical University of Vienna, Vienna, 1090, Austria., Seiser C; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, 1090, Austria., Berger J; Department of Pathobiology of the Nervous System, Centre for Brain Research, Medical University of Vienna, Vienna, 1090, Austria.

Publikováno v: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2020 Nov; Vol. 7 (11), pp. 2161-2177. Date of Electronic Publication: 2020 Sep 30.

Histone deacetylase 1 (HDAC1): A key player of T cell-mediated arthritis.

Autor: Göschl L; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, 1090, Vienna, Austria., Preglej T; Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria., Boucheron N; Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria., Saferding V; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, 1090, Vienna, Austria; Ludwig Boltzmann Institute for Arthritis and Rehabilitation, 1090, Vienna, Austria., Müller L; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, 1090, Vienna, Austria; Ludwig Boltzmann Institute for Arthritis and Rehabilitation, 1090, Vienna, Austria., Platzer A; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, 1090, Vienna, Austria., Hirahara K; Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan; AMED-PRIME, AMED, Chiba, 260-8670, Japan., Shih HY; Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, United States., Backlund J; Department of Medical Biochemistry and Biophysics, Medical Inflammation Research, Karolinska Institute, 17177, Stockholm, Sweden., Matthias P; Friedrich Miescher Institute for Biomedical Research, 4058, Basel, Switzerland; Faculty of Sciences, University of Basel, 4031, Basel, Switzerland., Niederreiter B; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, 1090, Vienna, Austria., Hladik A; Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM), Vienna, Austria; Laboratory of Infection Biology, Department of Internal Medicine I, Medical University of Vienna, 1090, Vienna, Austria., Kugler M; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, 1090, Vienna, Austria., Gualdoni GA; Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090, Vienna, Austria., Scheinecker C; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, 1090, Vienna, Austria., Knapp S; Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM), Vienna, Austria; Laboratory of Infection Biology, Department of Internal Medicine I, Medical University of Vienna, 1090, Vienna, Austria., Seiser C; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Holmdahl R; Department of Medical Biochemistry and Biophysics, Medical Inflammation Research, Karolinska Institute, 17177, Stockholm, Sweden., Tillmann K; Division of Biomedical Research, Medical University of Vienna, 1090, Vienna, Austria., Plasenzotti R; Division of Biomedical Research, Medical University of Vienna, 1090, Vienna, Austria., Podesser B; Division of Biomedical Research, Medical University of Vienna, 1090, Vienna, Austria., Aletaha D; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, 1090, Vienna, Austria., Smolen JS; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, 1090, Vienna, Austria., Karonitsch T; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, 1090, Vienna, Austria., Steiner G; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, 1090, Vienna, Austria; Ludwig Boltzmann Institute for Arthritis and Rehabilitation, 1090, Vienna, Austria., Ellmeier W; Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria., Bonelli M; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, 1090, Vienna, Austria. Electronic address: michael.bonelli@meduniwien.ac.at.

Publikováno v: Journal of autoimmunity [J Autoimmun] 2020 Mar; Vol. 108, pp. 102379. Date of Electronic Publication: 2019 Dec 26.