The N-terminal substrate specificity of the SurE peptide cyclase

Autor: Fazal, A, Wheeler, J, Webb, ME, Seipke, RF

Publikováno v: Organic & Biomolecular Chemistry. 20:7232-7235

The N-terminal substrate specificity of the SurE peptide cyclase was elucidated using a combination of on-resin biomemtic substrates and conventional SNAC thioesters.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4bb0a8678f58cffeb82d4186e7e7480
https://doi.org/10.1039/d2ob01061e

A trans-acting cyclase off-loading strategy for non-ribosomal peptide synthetases

Autor: Thankachan, D, Fazal, A, Francis, D, Song, L, Webb, ME, Seipke, RF

The terminal step in the biosynthesis of nonribosomal peptides is the hydrolytic release and, frequently, macrocyclization of an aminoacyl-S-thioester by an embedded thioesterase. The surugamide biosynthetic pathway is composed of two nonribosomal pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::736f5c7b97f9f1331b5fe9b254dc4159

Revisiting unexploited antibiotics in search of new antibacterial drug candidates: the case of gamma-actinorhodin

Autor: Nass, NM, Farooque, S, Hind, C, Wand, ME, Randall, CP, Sutton, JM, Seipke, RF, Rayner, C, O'Neill, AJ

Of the thousands of natural product antibiotics discovered to date, only a handful have been developed for the treatment of bacterial infection. The clinically unexploited majority likely include compounds with untapped potential as antibacterial dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::aaa13654eefef2e3ad1065055c215d49

Regulation of antimycin biosynthesis by the orphan ECF RNA polymerase sigma factor σ (AntA.)

Autor: Seipke, RF, Patrick, E, Hutchings, MI

Antimycins are an extended family of depsipeptides that are made by filamentous actinomycete bacteria and were first isolated more than 60 years ago. Recently, antimycins have attracted renewed interest because of their activities against the anti-ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::d1a3d169fcd1a32e2e858e09cc97d237
https://eprints.whiterose.ac.uk/80025/1/Seipke_et_al_2014_PeerJ.pdf

ActinoBase: tools and protocols for researchers working on Streptomyces and other filamentous actinobacteria.

Autor: Feeney MA; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Newitt JT; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Addington E; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Algora-Gallardo L; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Allan C; Swansea University Institute of Life Science, College of Medicine, Swansea, Wales, UK., Balis L; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Birke AS; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Castaño-Espriu L; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Charkoudian LK; Haverford College, Department of Chemistry, USA., Devine R; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Gayrard D; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Hamilton J; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Hennrich O; Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures GmbH Inhoffenstraße 7B, 38124 Braunschweig, Germany., Hoskisson PA; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Keith-Baker M; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Klein JG; Haverford College, Department of Chemistry, USA., Kruasuwan W; Division of Bioinformatics and Data Management for Research, Research Group and Research Network Division, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Mark DR; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Mast Y; Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures GmbH Inhoffenstraße 7B, 38124 Braunschweig, Germany., McHugh RE; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., McLean TC; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Mohit E; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Munnoch JT; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Murray J; Department of Physics, SUPA, University of Strathclyde, Glasgow, G4 0NG, UK., Noble K; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Otani H; US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.; Lawrence Berkeley National Laboratory, Environmental Genomics and Systems Biology Division, Berkeley, CA 94720, USA., Parra J; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Pereira CF; Department of Insect Symbiosis, Max Planck Institute for Chemical Ecology, Hans-Knöll-Straße 8, 07745 Jena, Germany., Perry L; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Pintor-Escobar L; Biology Department, Edge Hill University, St Helens Road, Ormskirk, L39 4QP, UK., Pritchard L; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Prudence SMM; School of Biological and Behavioral Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK., Russell AH; Colorifix Ltd, Norwich Research Park, Norwich, UK., Schniete JK; Biology Department, Edge Hill University, St Helens Road, Ormskirk, L39 4QP, UK., Seipke RF; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK.; Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK., Sélem-Mojica N; Universidad Nacional Autónoma de México, Centro de Ciencias Matemáticas, en Morelia, Michoacán, Mexico., Undabarrena A; Departamento de Química & Centro de Biotecnología Daniel Alkalay Lowitt, Universidad Técnica Federico Santa María, Laboratorio de Microbiología Molecular y Biotecnología Ambiental, Valparaíso, 2340000, Chile., Vind K; Host-Microbe Interactomics Group, Wageningen University, 6708 WD Wageningen, The Netherlands., van Wezel GP; Microbial Biotechnology, Institute of Biology, Leiden University, Rapenburg, The Netherlands., Wilkinson B; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Worsley SF; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK., Duncan KR; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Fernández-Martínez LT; Biology Department, Edge Hill University, St Helens Road, Ormskirk, L39 4QP, UK., Hutchings MI; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK.

Publikováno v: Microbial genomics [Microb Genom] 2022 Jul; Vol. 8 (7).