The N-terminal substrate specificity of the SurE peptide cyclase

Autor: Fazal, A, Wheeler, J, Webb, ME, Seipke, RF

Publikováno v: Organic & Biomolecular Chemistry. 20:7232-7235

The N-terminal substrate specificity of the SurE peptide cyclase was elucidated using a combination of on-resin biomemtic substrates and conventional SNAC thioesters.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4bb0a8678f58cffeb82d4186e7e7480
https://doi.org/10.1039/d2ob01061e

Antibiotics made to order

Autor: Seipke, RF

Publikováno v: Science. 376:919-920

Antimicrobial drug resistance is a global threat to human health. There is an urgent need to discover new antibiotics whose modes of action circumvent prevalent clinical resistance mechanisms. Most antibiotics in clinical use are microbial natural pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0300fb2cbafaf90ae577a757521f06
https://doi.org/10.1126/science.abq3206

ActinoBase: tools and protocols for researchers working on Streptomyces and other filamentous actinobacteria.

Autor: Feeney MA; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Newitt JT; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Addington E; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Algora-Gallardo L; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Allan C; Swansea University Institute of Life Science, College of Medicine, Swansea, Wales, UK., Balis L; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Birke AS; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Castaño-Espriu L; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Charkoudian LK; Haverford College, Department of Chemistry, USA., Devine R; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Gayrard D; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Hamilton J; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Hennrich O; Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures GmbH Inhoffenstraße 7B, 38124 Braunschweig, Germany., Hoskisson PA; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Keith-Baker M; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Klein JG; Haverford College, Department of Chemistry, USA., Kruasuwan W; Division of Bioinformatics and Data Management for Research, Research Group and Research Network Division, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Mark DR; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Mast Y; Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures GmbH Inhoffenstraße 7B, 38124 Braunschweig, Germany., McHugh RE; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., McLean TC; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Mohit E; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Munnoch JT; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Murray J; Department of Physics, SUPA, University of Strathclyde, Glasgow, G4 0NG, UK., Noble K; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Otani H; US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.; Lawrence Berkeley National Laboratory, Environmental Genomics and Systems Biology Division, Berkeley, CA 94720, USA., Parra J; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Pereira CF; Department of Insect Symbiosis, Max Planck Institute for Chemical Ecology, Hans-Knöll-Straße 8, 07745 Jena, Germany., Perry L; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Pintor-Escobar L; Biology Department, Edge Hill University, St Helens Road, Ormskirk, L39 4QP, UK., Pritchard L; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Prudence SMM; School of Biological and Behavioral Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK., Russell AH; Colorifix Ltd, Norwich Research Park, Norwich, UK., Schniete JK; Biology Department, Edge Hill University, St Helens Road, Ormskirk, L39 4QP, UK., Seipke RF; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK.; Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK., Sélem-Mojica N; Universidad Nacional Autónoma de México, Centro de Ciencias Matemáticas, en Morelia, Michoacán, Mexico., Undabarrena A; Departamento de Química & Centro de Biotecnología Daniel Alkalay Lowitt, Universidad Técnica Federico Santa María, Laboratorio de Microbiología Molecular y Biotecnología Ambiental, Valparaíso, 2340000, Chile., Vind K; Host-Microbe Interactomics Group, Wageningen University, 6708 WD Wageningen, The Netherlands., van Wezel GP; Microbial Biotechnology, Institute of Biology, Leiden University, Rapenburg, The Netherlands., Wilkinson B; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Worsley SF; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK., Duncan KR; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, G4 0RE, UK., Fernández-Martínez LT; Biology Department, Edge Hill University, St Helens Road, Ormskirk, L39 4QP, UK., Hutchings MI; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK.

Publikováno v: Microbial genomics [Microb Genom] 2022 Jul; Vol. 8 (7).

Revisiting unexploited antibiotics in search of new antibacterial drug candidates: the case of gamma-actinorhodin

Autor: Nass, NM, Farooque, S, Hind, C, Wand, ME, Randall, CP, Sutton, JM, Seipke, RF, Rayner, C, O'Neill, AJ

Of the thousands of natural product antibiotics discovered to date, only a handful have been developed for the treatment of bacterial infection. The clinically unexploited majority likely include compounds with untapped potential as antibacterial dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::aaa13654eefef2e3ad1065055c215d49

A Standalone β-Ketoreductase Acts Concomitantly with Biosynthesis of the Antimycin Scaffold.

Autor: Fazal A; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.; Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom.; School of Chemistry, University of Leeds, Leeds LS2 9JT, United Kingdom., Hemsworth GR; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.; Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom., Webb ME; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.; School of Chemistry, University of Leeds, Leeds LS2 9JT, United Kingdom., Seipke RF; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.; Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom.

Publikováno v: ACS chemical biology [ACS Chem Biol] 2021 Jul 16; Vol. 16 (7), pp. 1152-1158. Date of Electronic Publication: 2021 Jun 20.