Výsledky vyhledávání - "Seinosuke Iwata"

Discovery and evaluation of selective N-type calcium channel blockers: 6-Unsubstituted-1,4-dihydropyridine-5-carboxylic acid derivatives

Autor: Seiji Ohno, Masataka Shoji, Akira Takahara, Tomoko Takeda, Munetaka Tokumasu, Satoshi Iwayama, Seinosuke Iwata, Shinichi Fujita, Masako Hagihara, Seiji Niwa, Hajime Koganei, Takashi Yamamoto, Tomoyuki Onishi, Yuki Saitou

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:3639-3642

A structure–activity relationship study of 6-unsubstituted-1,4-dihydropyridine and 2,6-unsubstituted-1,4-dihydropyridine derivatives was conducted in an attempt to discover N-type calcium channel blockers that were highly selective over L-type calc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11785669960d9f5c026406e75f70952d
https://doi.org/10.1016/j.bmcl.2012.04.051

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Vascular Responsiveness to Various Vasoactive Substances After Exchange Transfusion with Pyridoxalated Hemoglobin Polyoxyethylene Conjugate (PHP) Solution in Anesthetized Rats

Autor: Katsuhide Nishi, Takashi Yamakawa, Seinosuke Iwata, Yuichi Gyoutoku, Akira Aikou, Yoshitoshi Kida

Publikováno v: Artificial Organs. 15:5-14

Vascular responsiveness to various vasoactive substances after exchange transfusion with a modified hemoglobin (pyridoxalated hemoglobin polyxyethylene conjugate; PHP) was examined in anesthetized rats. The hindlimb region of the rat was perfused thr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7952fc30c858a7037e5084fb653374
https://doi.org/10.1111/j.1525-1594.1991.tb00753.x

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The structure–activity relationship study on 2-, 5-, and 6-position of the water soluble 1,4-dihydropyridine derivatives blocking N-type calcium channels

Autor: Shinichi Fujita, Seiji Ohno, Seiji Niwa, Hajime Koganei, Yuki Saitou, Seinosuke Iwata, Akira Takahara, Tomoko Takeda, Tomoyuki Onishi, Takashi Yamamoto, Munetaka Tokumasu, Chika Nakanishi, Morikazu Kito, Akira Nakajo, Yukitsugu Ono, Masataka Shoji, Yoko Masuzawa

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:4813-4816

In order to find an injectable and selective N-type calcium channel blocker, we have performed the structure-activity relationship (SAR) study on the 2-, 5-, and 6-position of 1,4-dihydropyridine-3-carboxylate derivative APJ2708 (2), which is a deriv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86b1d751e45f33b333b46f09d74e181
https://doi.org/10.1016/j.bmcl.2008.07.096

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Structure–activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels

Autor: Akira Takahara, Seiji Ohno, Hiroyuki Matsueda, Hisayuki Uneyama, Masataka Shoji, Shinichi Fujita, Tomoko Takeda, Seinosuke Iwata, Tomoyuki Onishi, Seiji Niwa, Morikazu Kito, Hajime Koganei, Yuki Saitou, Yukitsugu Ono, Takashi Yamamoto

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 16:798-802

Cilnidipine is a 1,4-dihydropyridine derived L/N-type calcium channel dual blocker possessing neuroprotective and analgesic effects which are related to its N-type calcium channel inhibitory activity. In order to find specific N-type calcium channel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e409c773f0b8a9e6feef5d47c8042074
https://doi.org/10.1016/j.bmcl.2005.11.021

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Antisympathetic and hemodynamic property of a dual L/N-type Ca2+ channel blocker cilnidipine in rats

Autor: Seinosuke Iwata, Akira Takahara, Tomoko Takeda, Hajime Koganei

Publikováno v: European Journal of Pharmacology. 434:43-47

The in vivo antisympathetic property of a dual L/N-type Ca(2+) channel blocker cilnidipine compared with that of typical N-type Ca(2+) channel blockers has never been clarified. We investigated the effects of the drug on a sympathetic nerve-mediated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8671442a5e1660499867a49f60ed7b
https://doi.org/10.1016/s0014-2999(01)01521-7

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Asymmetric synthesis and biological evaluations of (+)- and (−)-6-dimethoxymethyl-1,4-dihydropyridine-3-carboxylic acid derivatives blocking N-type calcium channels

Autor: Seiji Ohno, Akira Takahara, Yuki Saitou, Munetaka Tokumasu, Shinichi Fujita, Seinosuke Iwata, Tomoko Takeda, Masako Hagihara, Satoshi Iwayama, Seiji Niwa, Hajime Koganei, Takashi Yamamoto, Masataka Shoji

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 21:3317-3319

An efficient asymmetric synthesis of 1,4-dihydropyridine derivatives is described. The key step is the stereoselective Michael addition using t-butyl ester of L-valine as a chiral auxiliary to achieve good ee (>95% for all the tested experiments) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0493b5edab6479967db8b370748fef72
https://doi.org/10.1016/j.bmcl.2011.04.007

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Intraarterial Perfusion of the Hindlimb with Pyridoxalated Hemoglobin Polyoxyethylene Conjugate Solution in Anesthetized Dogs

Autor: Yuji Iwashita, Yoshihiro Kadowaki, Seinosuke Iwata, Katsuhide Nishi, Yoshitoshi Kida, Shuichi Iwasaki, Takashi Yamakawa, Nobuyuki Furusho

Publikováno v: Artificial Organs. 19:511-518

To evaluate the potential clinical usefulness of a modified hemoglobin, pyridoxalated hemoglobin polyoxyethylene conjugate (PHP), the hindlimb vascular bed was perfused with PHP solution while monitoring tissue oxygen tension (PtO2) in anesthetized d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4d71a9a068fddc7cbf97ac1350192a
https://doi.org/10.1111/j.1525-1594.1995.tb02371.x

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Pharmacological Characteristics of the Canine Cerebrovascular Constriction Produced by Neuropeptide Y

Autor: Tsuneo Ishiguro, Seinosuke Iwata, Hisayuki Uneyama, Yoshio Tanaka, Koichi Nakayama

Publikováno v: Biological and Pharmaceutical Bulletin. 18:501-506

In order to elucidate the role of neuropeptide Y (NPY) in cerebral circulation, we undertook the present study to examine the action of NPY itself, and the combined effects of NPY with other vasoconstrictor stimuli. NPY itself produced contractions o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ffa8d342445d4f3d3656cb27e1716c
https://doi.org/10.1248/bpb.18.501

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Suppression of formalin-induced nociception by cilnidipine, a voltage-dependent calcium channel blocker

Autor: Seinosuke Iwata, Masataka Shoji, Hajime Koganei

Publikováno v: Biologicalpharmaceutical bulletin. 32(10)

Cilnidipine is a 1,4-dihydropyridine-derived voltage-dependent calcium channel (VDCC) blocker and suppresses N-type VDCC currents in addition to L-type VDCC currents. An earlier investigation has suggested that intrathecally injected cilnidipine prod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf4020e608b274b7fdfd16341e410fea
https://pubmed.ncbi.nlm.nih.gov/19801830

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Discovery, structure-activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity

Autor: Tomoko Takeda, Satoshi Iwayama, Hiroshi Yamamoto, Seinosuke Iwata, Shinichi Fujita, Yukitsugu Ono, Masataka Shoji, Morikazu Kito, Akira Takahara, Seiji Niwa, Hajime Koganei, Takashi Yamamoto, Yuki Saitou

Publikováno v: Bioorganicmedicinal chemistry. 14(15)

Antiallergic drug cyproheptadine (Cyp) is known to have inhibitory activities for L-type calcium channels in addition to histamine and serotonin receptors. Since we found that Cyp had an inhibitory activity against N-type calcium channel, Cyp was opt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15fb0ee32d5ed68367bdf3d63489ad4c
https://pubmed.ncbi.nlm.nih.gov/16616501

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