Mimicking the Nucleosomal Context in Peptide-Based Binders of a H3K36me Reader Increases Binding Affinity While Altering the Binding Mode

Autor: Velten Horn, Seino A. K. Jongkees, Hugo van Ingen

Publikováno v: Molecules, Vol 25, Iss 21, p 4951 (2020)

Targeting of proteins in the histone modification machinery has emerged as a promising new direction to fight disease. The search for compounds that inhibit proteins that readout histone modification has led to several new epigenetic drugs, mostly fo

Externí odkaz: https://doaj.org/article/55042f92cfac46e0b5b78eeaab29e99c

A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein

Autor: Vito Thijssen, Daniel L. Hurdiss, Oliver J. Debski-Antoniak, Matthew A. Spence, Charlotte Franck, Alexander Norman, Anupriya Aggarwal, Nadia J. Mokiem, David A. A. van Dongen, Stein W. Vermeir, Minglong Liu, Wentao Li, Marianthi Chatziandreou, Tim Donselaar, Wenjuan Du, Ieva Drulyte, Berend-Jan Bosch, Joost Snijder, Stuart Turville, Richard J. Payne, Colin J. Jackson, Frank J. M. van Kuppeveld, Seino A. K. Jongkees

The ongoing COVID-19 pandemic has had great societal and health consequences. Despite the availability of vaccines, infection rates remain high due to immune evasive Omicron sublineages. Broad-spectrum antivirals are needed to safeguard against emerg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bef323aac59161513088436e62791ac
https://dspace.library.uu.nl/handle/1874/429162

Macrocyclic peptides as allosteric inhibitors of nicotinamide N-methyltransferase (NNMT)

Autor: Agnieszka Kij, Davide Sartini, Roberto Campagna, Nathaniel I. Martin, Monica Emanuelli, Seino A. K. Jongkees, Ned Buijs, Matthijs J. van Haren, Yurui Zhang, Filip A. Fedak, Stefan Chlopicki, Yongzhi Gao, Lukasz Mateuszuk, Vito Thijssen

Publikováno v: RSC Chemical Biology, 2(5), 1546-1555
RSC Chemical Biology, 2(5), 1546-1555. Royal Society of Chemistry
Van Haren, M J, Zhang, Y, Thijssen, V, Buijs, N, Gao, Y, Mateuszuk, L, Fedak, F A, Kij, A, Campagna, R, Sartini, D, Emanuelli, M, Chlopicki, S, Jongkees, S A K & Martin, N I 2021, ' Macrocyclic peptides as allosteric inhibitors of nicotinamide : N-methyltransferase (NNMT) ', RSC Chemical Biology, vol. 2, no. 5, pp. 1546-1555 . https://doi.org/10.1039/d1cb00134e

Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide to form 1-methylnicotinamide (MNA) using S-Adenosyl-l-methionine (SAM) as the methyl donor. The complexity of the role of NNMT in healthy and disease states is slowly being elucidated an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1116988d55e21d6626c3b65db4b9d7f9
https://doi.org/10.1039/d1cb00134e

Macrocyclic peptides as allosteric inhibitors of nicotinamide

Autor: Matthijs J, van Haren, Yurui, Zhang, Vito, Thijssen, Ned, Buijs, Yongzhi, Gao, Lukasz, Mateuszuk, Filip A, Fedak, Agnieszka, Kij, Roberto, Campagna, Davide, Sartini, Monica, Emanuelli, Stefan, Chlopicki, Seino A K, Jongkees, Nathaniel I, Martin

Publikováno v: RSC Chemical Biology

Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide to form 1-methylnicotinamide (MNA) using S-adenosyl-l-methionine (SAM) as the methyl donor. The complexity of the role of NNMT in healthy and disease states is slowly being elucidated an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::62e64ffa1d22b318e9cb743b72c2568b
https://pubmed.ncbi.nlm.nih.gov/34704059

Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes

Autor: Štefan Janeček, Rohan J. Williams, Geoff Pincher, Darrell Cockburn, Gurvan Michel, Wataru Saburi, David R. Rose, Brian P. Rempel, Glyn R. Hemsworth, Wim Van den Ende, Jerry Ståhlberg, Leila LoLeggio, Tom Wennekes, Kiyohiko Igarashi, Cedric Montanier, Etienne Rebuffet, Naotake Konno, Harry J. Gilbert, Markus Linder, Ed Bayer, Tirso Pons, Jan-Hendrik Hehemann, Tomomi Sumida, Thierry Fontaine, Takane Katayama, Elizabeth Ficko-Blean, Florence Vincent, Zui Fujimoto, Masafumi Hidaka, Kyle Robinson, Ana R. Luís, Yuichi Sakamoto, Bernard Henrissat, Gustav Vaaje-Kolstad, Jens M. Eklöf, Ian R. Greig, Harry Brumer, Ryuichiro Suzuki, Mats Sandgren, Takashi Tonozuka, Ryszard Brzezinski, Brian L. Mark, Bareket Dassa, Haruhide Mori, Junho Lee, Vivian L. Y. Yip, Birte Svensson, Wade Abbott, Alfons K. G. Felice, Juha Rouvinen, Takayuki Ohnuma, Satoshi Kaneko, Franz J. St John, Ramon Hurtado-Guerrero, Pedro M. Coutinho, Sine Larsen, Gideon J. Davies, Yuval Shoham, Kiyotaka Fujita, Warren W. Wakarchuk, Fathima Aidha Shaikh, Alisdair B. Boraston, Breeanna R. Urbanowicz, Vincent G. H. Eijsink, Daniel Kracher, Beatrice Cobucci-Ponzano, Ethan D. Goddard-Borger, Anthony J. Clarke, David J. Vocadlo, Katsuro Yaoi, Seino A. K. Jongkees, Anna A. Kulminskaya, Roland Ludwig, Mirko M. Maksimainen, Magali Remaud-Simeon, Edward J. Taylor, Motomitsu Kitaoka, Spencer J. Williams, Shinya Fushinobu, Marco Moracci, David Wilson, Richard McLean, Toki Taira, Jean-Guy Berrin, Ran Zhang, Hiroyuki Nakai, Tracey M. Gloster, Peter J. Reilly, Wim Nerinckx, Takuya Ishida, Alicia Lammerts van Bueren, Orly Alber, Mirjam Czjzek, Kathleen Piens, Annabelle Varrot, Stephen G. Withers, Nathalie Juge, Maxime Versluys, Gerlind Sulzenbacher, Richard W. Pickersgill, Michael D. L. Suits

Publikováno v: Glycobiology
Glycobiology, Oxford University Press (OUP), 2018, 28 (1), pp.3-8. ⟨10.1093/glycob/cwx089⟩
Glycobiology, 2018, 28 (1), pp.3-8. ⟨10.1093/glycob/cwx089⟩
Glycobiology (Oxf.) 28 (2018): 3–8. doi:10.1093/glycob/cwx089
info:cnr-pdr/source/autori:Abbott, Wade; Alber, Orly; Bayer, Ed; Berrin, Jean-Guy; Boraston, Alisdair; Brumer, Harry; Brzezinski, Ryszard; Clarke, Anthony; Cobucci-Ponzano, Beatrice; Cockburn, Darrell; Coutinho, Pedro; Czjzek, Mirjam; Dassa, Bareket; Davies, Gideon John; Eijsink, Vincent; Eklof, Jens; Felice, Alfons; Ficko-Blean, Elizabeth; Pincher, Geoff; Fontaine, Thierry; Fujimoto, Zui; Fujita, Kiyotaka; Fushinobu, Shinya; Gilbert, Harry; Gloster, Tracey; Goddard-Borger, Ethan; Greig, Ian; Hehemann, Jan-Hendrik; Hemsworth, Glyn; Henrissat, Bernard; Hidaka, Masafumi; Hurtado-Guerrero, Ramon; Igarashi, Kiyohiko; Ishida, Takuya; Janecek, Stefan; Jongkees, Seino; Juge, Nathalie; Kaneko, Satoshi; Katayama, Takane; Kitaoka, Motomitsu; Konno, Naotake; Kracher, Daniel; Kulminskaya, Anna; van Bueren, Alicia Lammerts; Larsen, Sine; Lee, Junho; Linder, Markus; LoLeggio, Leila; Ludwig, Roland; Luis, Ana; Maksimainen, Mirko; Mark, Brian; McLean, Richard; Michel, Gurvan; Michel, Gurvan; Montanier, Cedric; Moracci, Marco; Mori, Haruhide; Nakai, Hiroyuki; Nerinckx, Wim; Ohnuma, Takayuki; Pickersgill, Richard; Piens, Kathleen; Pons, Tirso; Rebuffet, Etienne; Reilly, Peter; Remaud-Simeon, Magali; Rempel, Brian; Robinson, Kyle; Rose, David; Rouvinen, Juha; Saburi, Wataru; Sakamoto, Yuichi; Sandgren, Mats; Shaikh, Fathima; Shoham, Yuval; St John, Franz; Stahlberg, Jerry; Suits, Michael; Sulzenbacher, Gerlind; Sumida, Tomomi; Suzuki, Ryuichiro; Svensson, Birte; Taira, Toki; Taylor, Ed; Tonozuka, Takashi; Urbanowicz, Breeanna; Vaaje-Kolstad, Gustav; Van den Ende, Wim; Varrot, Annabelle; Versluys, Maxime; Vincent, Florence; Vocadlo, David; Wakarchuk, Warren; Wennekes, Tom; Williams, Rohan; Williams, Spencer; Wilson, David; Withers, Stephen; Yaoi, Katsuro; Yip, Vivian; Zhang, Ran/titolo:Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes/doi:10.1093%2Fglycob%2Fcwx089/rivista:Glycobiology (Oxf.)/anno:2018/pagina_da:3/pagina_a:8/intervallo_pagine:3–8/volume:28
Abbott, W, Alber, O, bayer, E, Berrin, J-G, Boraston, A, Brumer, H, Brzezinski, R, Clarke, A, Cobucci-Ponzano, B, Cockburn, D, Coutinho, P, Czjzek, M, Dassa, B, Davies, G J, Eijsink, V, Eklöf, J, Felice, A, Ficko-Blean, E, Fincher, G, Fontaine, T, Fujimoto, Z, Fujita, K, Fushinobu, S, Gilbert, H, Gloster, T, Goddard-Borger, E, Greig, I, Hehemann, J-H, Hemsworth, G, Henrissat, B, Hidaka, M, Hurtado-Guerrero, R, Igarashi, K, Ishida, T, Janeček, Š, Jongkees, S, Juge, N, Kaneko, S, Katayama, T, Kitaoka, M, Konno, N, Kracher, D, Kulminskaya, A, Lammerts van Bueren, A, Larsen, S, Lee, J, Linder, M, Lo Leggio, L, Ludwig, R, Luis, A, Maksimainen, M, Mark, B, McLean, R, Michel, G, Montanier, C, Moracci, M, Mori, H, Nakai, H, Nerinckx, W, Ohnuma, T, Pickersgill, R, Piens, K, Pons, T, Rebuffet, E, Reilly, P, Remaud-Simeon, M, Rempel, B, Robinson, K, Rose, D, Rouvinen, J, Saburi, W, Sakamoto, Y, Sandgren, M, Shaikh, F, Shoham, Y, St. John, F, Stahlberg, J, Suits, M, Sulzenbacher, G, Sumida, T, Suzuki, R, Svensson, B, Taira, T, Taylor, E, Tonozuka, T, Urbanowicz, B, Vaaje-Kolstad, G, Van den Ende, W, Varrot, A, Verluys, M, Vincent, F, Vocadlo, D, Wakarchuk, W, Wennekes, T, Williams, R, Williams, S, Wilkens, C, Wilson, D, Withers, S, Yaoi, K, Yip, V & Zhang, R 2018, ' Ten years of CAZypedia : a living encyclopedia of carbohydrate-active enzymes ', Glycobiology, vol. 28, no. 1, pp. 3-8 . https://doi.org/10.1093/glycob/cwx089
GLYCOBIOLOGY
Glycobiology, 28(1), 3. Oxford University Press

CAZypedia was initiated in 2007 to create a comprehensive, living encyclopedia of the carbohydrate-active enzymes (CAZymes) and associated carbohydrate-binding modules involved in the synthesis, modification, and degradation of complex carbohydrates.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd922fbf8f91c4c149f1a6b7dd921fd
https://hal.archives-ouvertes.fr/hal-01886461/document