Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Seiko Hirano"'
1
Mutations of the Corynebacterium glutamicum NCgl1221 Gene, Encoding a Mechanosensitive Channel Homolog, Induce l -Glutamic Acid Production
Autor: Jun Nakamura, Hisao Ito, Seiko Hirano, Masaaki Wachi
Publikováno v: Applied and Environmental Microbiology. 73:4491-4498
Corynebacterium glutamicum is a biotin auxotroph that secretes l -glutamic acid in response to biotin limitation; this process is employed in industrial l -glutamic acid production. Fatty acid ester surfactants and penicillin also induce l -glutamic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a2f6a042263da6eba749b7294df6f82
https://doi.org/10.1128/aem.02446-06
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2
ChemInform Abstract: Synthesis and Biological Evaluation of Phenylacetyl Derivatives Having Low Central Nervous System Permeability as Potent and Selective M2 Muscarinic Receptor Antagonists
Autor: Yoko Yamagiwa, Akio Kakefuda, Seiko Hirano, Kenji Takizawa, Isao Yanagisawa, Hiroshi Shibata, Toshihiro Watanabe, Akihiro Tanaka
Publikováno v: ChemInform. 29
A series of phenylacetyl derivatives containing the 5, 10-dihydro-11H-dibenzo[b, e][1, 4]diazepin-11-one or 5, 11-dihydro-6H-pyrido[2, 3-b][1, 4]benzodiazepin-6-one skeleton was prepared and evaluated for their binding affinities to muscarinic recept
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b2d9205718d118bae37d979ecf2f06a
https://doi.org/10.1002/chin.199829189
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3
ChemInform Abstract: Synthesis and Biological Evaluation of 1,2,3,4-Tetrahydroisoquinoline Derivatives as Potent and Selective M2 Muscarinic Receptor Antagonists
Autor: Tadao Shibanuma, Toshihiro Watanabe, Kenji Takizawa, Seiko Hirano, Isao Kinoyama
Publikováno v: ChemInform. 30
A series of 1, 2, 3, 4-tetrahydroisoquinoline derivatives containing the 5, 11-dihydro-6H-pyrido[2, 3-b][1, 4]benzodiazepin-6-one skeleton were prepared and evaluated for their in vitro binding affinities to muscarinic receptors and for antagonism of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f942bb487057ee73ffd3e4f43d1c750
https://doi.org/10.1002/chin.199945193
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4
Synthesis and biological evaluation of 1,2,3,4-tetrahydroisoquinoline derivatives as potent and selective M2 muscarinic receptor antagonists
Autor: Isao Kinoyama, Seiko Hirano, Toshihiro Watanabe, Kenji Takizawa, Tadao Shibanuma
Publikováno v: Chemicalpharmaceutical bulletin. 47(5)
A series of 1, 2, 3, 4-tetrahydroisoquinoline derivatives containing the 5, 11-dihydro-6H-pyrido[2, 3-b][1, 4]benzodiazepin-6-one skeleton were prepared and evaluated for their in vitro binding affinities to muscarinic receptors and for antagonism of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969ae5d73ce14bbceb64fa05449a8287
https://pubmed.ncbi.nlm.nih.gov/10361700
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5
Synthesis and biological evaluation of phenylacetyl derivatives having low central nervous system permeability as potent and selective M2 muscarinic receptor antagonists
Autor: Yoko Yamagiwa, Akihiro Tanaka, Hiroshi Shibata, Akio Kakefuda, Isao Yanagisawa, Toshihiro Watanabe, Kenji Takizawa, Seiko Hirano
Publikováno v: Chemicalpharmaceutical bulletin. 46(1)
A series of phenylacetyl derivatives containing the 5, 10-dihydro-11H-dibenzo[b, e][1, 4]diazepin-11-one or 5, 11-dihydro-6H-pyrido[2, 3-b][1, 4]benzodiazepin-6-one skeleton was prepared and evaluated for their binding affinities to muscarinic recept
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ddfe7451ff87c3bd15700817b200ecf
https://pubmed.ncbi.nlm.nih.gov/9468637
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6
Synthesis of novel succinamide derivatives having the 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one skeleton as potent and selective M2 muscarinic receptor antagonists. I
Autor: Toshihiro WATANABE, Isao KINOYAMA, Akio KAKEFUDA, Toshio OKAZAKI, Kenji TAKIZAWA, Seiko HIRANO, Hiroshi SHIBATA, Isao YANAGISAWA
Publikováno v: Chemicalpharmaceutical bulletin. 45(6)
A series of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one derivatives containing the succinamide skeleton has been synthesized and evaluated for M1, M2 and M3 muscarinic receptor binding affinities (in vitro) and M2 and M3 muscarinic receptor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda70aba1310b5411f9a800d7886933f
https://pubmed.ncbi.nlm.nih.gov/9214706
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8
Detection of high levels of immunoreactive human beta-1 interferon in sera from HIV-infected patients
Autor: Yu ichiro Satoh, Kei Hachimori, Mizuno K, Akihiko Numata, Akio Nakane, Misako Asano, Masayoshi Negishi, Tomonori Minagawa, Seiko Hirano, Sigenori Tamagawa, Shojiro Yamazaki, Masashi Kohanawa
Publikováno v: Life sciences. 45(11)
We have examined human interferon beta-1 (HuIFN-beta 1) levels in the sera from patients with various diseases by using a newly developed highly sensitive enzyme-linked immunosorbent assay system (ELISA). High levels of HuIFN-beta 1 were detected in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc3b154037bd77393e8caaa7c6a8b59
https://pubmed.ncbi.nlm.nih.gov/2796591
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