Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Seijiro Hara"'
Autor:
Kohji Nomura, Akemi Nakamura, Norito Yoshimura, Masayuki Sugimoto, Takanori Iwasaki, Midori Kojima, Kohji Hanasaki, Keita Fukao, Toru Nakano, Ken-Ichiro Uwabe, Seijiro Hara, Tadateru Hamada, Toshihiro Shinosaki, Noriyuki Naya, Keiichi Imagawa
Publikováno v:
Metabolism. 65:16-25
Objective Although peroxisome proliferator-activated receptor (PPAR) δ agonists have been shown to improve the serum lipoprotein profiles in humans, the impact of the changes in these lipoprotein profiles on atherosclerosis remains to be elucidated.
Autor:
Yumiko Matsuo, Seijiro Hara, Takushi Kanazu, Hiroyuki Shimaoka, Kenji Miyata, Hiroyuki Kusuhara, Shingo Sakamoto, Noboru Okamura, Takahiko Baba, Kazutoshi Horie, Yuichi Sugiyama, Kohji Nomura
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 322:610-618
Methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) is a novel inhibitor of the ileal apical sodium-dependent bile acid transporter (ASBT/SLC10A2) developed for the treatment of hypercholesterolemia. The
Publikováno v:
Japanese Heart Journal. 34:439-449
The effects of the endogenous pressor agents noradrenaline (NA), and angiotensin II (Ang II), and of the hypotensive agents acetylcholine (ACh) and adenosine (ADS), on blood pressure and heart rate in conscious and unrestrained stroke-prone spontaneo
Publikováno v:
Circulation. 118
PPARδ is one of the transcription factors that regulate lipid metabolism. Recently, PPARδ agonists have been reported to induce the elevation of plasma HDL-C levels in obese mice, rhesus monkeys as well as humans, indicating their potentials as a n
Publikováno v:
Drug Development Research. 20:453-464
The prophylactic effects of several Ca antagonists against the incidence of cerebral stroke in stroke-prone spontaneously hypertensive rats (SHRSP) (9-17 weeks of age) fed a stroke-prone (SP) diet (Na, 0.39%) were investigated for 8 weeks. The contro
Autor:
Takuji Mizui, Tsutomu Shike, Junko Higaki, Seijiro Hara, Kenji Miyata, Nobuo Takasu, Kiyoshi Nagata, Kanya Tonda
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 18(8)
Abstract —The ileal Na + /bile acid cotransporter (IBAT) plays an important role in the enterohepatic circulation of bile acids. We investigated the effects of IBAT inhibition on the maintenance of serum cholesterol level by using a novel IBAT inhi
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 17(7)
Abstract We examined the effects of lysophosphatidylcholine (lyso-PC) on promoting cholesterol efflux from macrophage foam cells. Mouse peritoneal macrophages were converted to foam cells by incubation with [ 3 H]cholesteryl linoleate–labeled or un
Autor:
Kenji Miyata, Takuji Mizui, Seijiro Hara, Ken-ichi Higashino, Yasumasa Goh, Kanya Tonda, Nobuo Takasu, Mie Iwai, Junko Higaki, Kiyoshi Nagata
Publikováno v:
Life sciences. 60(24)
The ileal Na+/bile acid cotransporter (IBAT) maintains the reabsorption of bile acids from the intestine in the enterohepatic circulation of bile acids. In the present study, we showed that S-8921 could dose-dependently inhibit the uptake of [ 3 H]ta
Publikováno v:
Japanese Journal of Pharmacology. 76:106
Publikováno v:
European Journal of Pharmacology. 160:313-321
We compared the properties of vascular and platelet thromboxane A2/prostaglandin H2 receptors in the pig. The binding profiles of U46619, several prostaglandins and thromboxane A2/prostaglandin H2 receptor antagonists to the aorta and platelet recept