Výsledky vyhledávání - "Seiji Tamura"

Design, synthesis, and biological evaluation of novel biphenyl-4-carboxamide derivatives as orally available TRPV1 antagonists

Autor: Toshihiro Watanabe, Koichi Yonezawa, Takahiro Kuramochi, Kazuhiro Ikegai, Seiji Tamura, Norio Asai, Tetsuo Kiso, Akio Kamikawa, Satoshi Miyamoto, Takemoto Yukihiro, Hiromasa Oka, Shohei Shirakami

Publikováno v: Bioorganic & Medicinal Chemistry. 26:3716-3726

A new series of transient receptor potential vanilloid type 1 (TRPV1) antagonists were designed and synthesized from N-(3-hydroxyphenyl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamide hydrochloride (8). SAR studies identified (R)-N-(1-methyl-2-oxo-1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e645480def4cc351f241cf20a0e41756
https://doi.org/10.1016/j.bmc.2018.06.001

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AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in rat models of nociceptive pain

Autor: Nobuya Matsuoka, Nobuaki Takeshita, Nobuhito Murai, Megumi Irie, Toshiaki Aoki, Seiji Tamura, Fusako Nishigaki

Publikováno v: Neurological Research. 37:525-530

The (+)-isomer of indeloxazine AS1069562 has multiple pharmacological actions, such as serotonin (5-HIT) and norepinephrine (NE) reuptake inhibition and analgesic effects in animal models of neuropathic pain. Here, we investigated the analgesic effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03605e24e62a95a84e84b5133ab76014
https://doi.org/10.1179/1743132815y.0000000007

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AS1069562, the (+)-Isomer of Indeloxazine, Exerts Analgesic Effects in a Rat Model of Neuropathic Pain with Unique Characteristics in Spinal Monoamine Turnover

Autor: Seiji Tamura, Tomoya Oe, Mina Tsukamoto, Ryugo Enomoto, Nobuya Matsuoka, Toshihiro Sekizawa, Toshiaki Aoki, Nozomu Hamakawa, Nobuhito Murai, Shuichiro Kakimoto

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 348:372-382

AS1069562 [(R)-2-[(1H-inden-7-yloxy)methyl]morpholine monobenzenesulfonate] is the (+)-isomer of indeloxazine, which had been used clinically for the treatment of cerebrovascular diseases with multiple pharmacological actions, including serotonin (5-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd52a664d862c3f2e29bdbe47db59e4
https://doi.org/10.1124/jpet.113.208686

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Radioligand Binding Properties and Pharmacological Characterization of 6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a High-Affinity, Selective, and Noncompetitive Antagonist of Metabotropic Glutamate Receptor Type 1

Autor: Shigeki Kawabata, Takashi Toya, Yoshitsugu Shitaka, Tomonari Watabiki, Masamichi Okada, Yukinori Nagakura, Atsuyuki Kohara, Seiji Tamura, Satoshi Hayashibe

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 315:163-169

Metabotropic glutamate receptor type 1 (mGluR1) is thought to play important roles in the neurotransmission and pathogenesis of several neurological disorders. Here, we describe the radioligand binding properties and pharmacological effects of a newl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294a69d9f941fe1c14aadfce3c5c5375
https://doi.org/10.1124/jpet.105.087171

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Signal Fluctuation and Neutron Source in Inverse Kinetics Method for Reactivity Measurement in the Sub-critical Domain

Autor: Seiji Tamura

Publikováno v: Journal of Nuclear Science and Technology. 40:153-157

This paper presents numerical experiments on reactivity measurement by the inverse kinetics method in the sub-critical domain or at low power. The increase in the fluctuation of the neutron signal at low power levels will cause difficulties in the ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f99cf25a22c30f626ec527d6273f821d
https://doi.org/10.1080/18811248.2003.9715345

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Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats

Autor: Megumi Irie, Sokichi Honda, Nobuhito Murai, A. Iwashita, Seiji Tamura, Yoshihiro Murakami, Toshiaki Aoki, Yukinori Nagakura, Hiroshi Fushiki

Publikováno v: Neuroscience. 289

Serotonin (5-HT) and norepinephrine (NE) have been implicated in the mediation of endogenous analgesic mechanisms via the descending inhibitory pain pathway in the brain, and dysfunction in both the 5-HT and NE systems has been suggested as an etiolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6d8d5940ec7bfb40e8bfed31ba49fe
https://pubmed.ncbi.nlm.nih.gov/25595980

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Lipid Peroxidation, Antioxidative Enzyme Activities, and Cytosolic Free Calcium Levels in Rat Hippocampus-Derived Cells Exposed to Free Radicals

Autor: Naoaki Matsuki, Kenichiro Ono, Takashi Onodera, Asako Takanohashi, Seiji Tamura, Makoto Bonkobara

Publikováno v: Journal of Veterinary Medical Science. 60:63-69

To elucidate mechanisms of free radical-induced neuronal cell death, lipid peroxidation measured as thiobarbituric acid-reactive substances (TBARS), three antioxidative enzyme activities (superoxide dismutase, glutathione peroxidase, and catalse), an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56935d0801a7f9d799d5e64e09778be
https://doi.org/10.1292/jvms.60.63

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Neuroprotective effects of the selective type 1 metabotropic glutamate receptor antagonist YM-202074 in rat stroke models

Autor: Yoshitsugu Shitaka, Seiji Tamura, Masamichi Okada, Atsuyuki Kohara, Shinichi Yatsugi, Shigeki Kawabata, Masayasu Takahashi, Satoshi Hayashibe

Publikováno v: Brain research. 1191

We describe in vitro properties and in vivo neuroprotective effects of a newly synthesized, high-affinity, selective allosteric metabotropic glutamate receptor type 1 (mGluR(1)) antagonist, N-cyclohexyl-6-{[(2-methoxyethyl)(methyl)amino]methyl}-N-met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30db61881c49fb9a2081684d6724f17
https://pubmed.ncbi.nlm.nih.gov/18164695

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Antinociceptive profile of a selective metabotropic glutamate receptor 1 antagonist YM-230888 in chronic pain rodent models

Autor: Yoshitsugu Shitaka, Yukinori Nagakura, Tetsuo Kiso, Takashi Toya, Tomonari Watabiki, Masamichi Okada, Atsuyuki Kohara, Hirotsune Itahana, Seiji Tamura

Publikováno v: European journal of pharmacology. 571(1)

Metabotropic glutamate receptor 1 (mGlu 1 receptor) has been suggested to play an important role in pain transmission. In this study, the effects of a newly-synthesized mGlu 1 receptor antagonist, ( R )- N -cycloheptyl-6-({[(tetrahydro-2-furyl)methyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185ac1b9c70bc00c55e8b89582953bd5
https://pubmed.ncbi.nlm.nih.gov/17597604

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