Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Seiji Tamura"'
Autor:
Toshihiro Watanabe, Koichi Yonezawa, Takahiro Kuramochi, Kazuhiro Ikegai, Seiji Tamura, Norio Asai, Tetsuo Kiso, Akio Kamikawa, Satoshi Miyamoto, Takemoto Yukihiro, Hiromasa Oka, Shohei Shirakami
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:3716-3726
A new series of transient receptor potential vanilloid type 1 (TRPV1) antagonists were designed and synthesized from N-(3-hydroxyphenyl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamide hydrochloride (8). SAR studies identified (R)-N-(1-methyl-2-oxo-1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e645480def4cc351f241cf20a0e41756
https://doi.org/10.1016/j.bmc.2018.06.001
https://doi.org/10.1016/j.bmc.2018.06.001
Autor:
Nobuya Matsuoka, Nobuaki Takeshita, Nobuhito Murai, Megumi Irie, Toshiaki Aoki, Seiji Tamura, Fusako Nishigaki
Publikováno v:
Neurological Research. 37:525-530
The (+)-isomer of indeloxazine AS1069562 has multiple pharmacological actions, such as serotonin (5-HIT) and norepinephrine (NE) reuptake inhibition and analgesic effects in animal models of neuropathic pain. Here, we investigated the analgesic effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03605e24e62a95a84e84b5133ab76014
https://doi.org/10.1179/1743132815y.0000000007
https://doi.org/10.1179/1743132815y.0000000007
Autor:
Seiji Tamura, Tomoya Oe, Mina Tsukamoto, Ryugo Enomoto, Nobuya Matsuoka, Toshihiro Sekizawa, Toshiaki Aoki, Nozomu Hamakawa, Nobuhito Murai, Shuichiro Kakimoto
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 348:372-382
AS1069562 [(R)-2-[(1H-inden-7-yloxy)methyl]morpholine monobenzenesulfonate] is the (+)-isomer of indeloxazine, which had been used clinically for the treatment of cerebrovascular diseases with multiple pharmacological actions, including serotonin (5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd52a664d862c3f2e29bdbe47db59e4
https://doi.org/10.1124/jpet.113.208686
https://doi.org/10.1124/jpet.113.208686
Autor:
Shigeki Kawabata, Takashi Toya, Yoshitsugu Shitaka, Tomonari Watabiki, Masamichi Okada, Yukinori Nagakura, Atsuyuki Kohara, Seiji Tamura, Satoshi Hayashibe
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 315:163-169
Metabotropic glutamate receptor type 1 (mGluR1) is thought to play important roles in the neurotransmission and pathogenesis of several neurological disorders. Here, we describe the radioligand binding properties and pharmacological effects of a newl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294a69d9f941fe1c14aadfce3c5c5375
https://doi.org/10.1124/jpet.105.087171
https://doi.org/10.1124/jpet.105.087171
Autor:
Seiji Tamura
Publikováno v:
Journal of Nuclear Science and Technology. 40:153-157
This paper presents numerical experiments on reactivity measurement by the inverse kinetics method in the sub-critical domain or at low power. The increase in the fluctuation of the neutron signal at low power levels will cause difficulties in the ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f99cf25a22c30f626ec527d6273f821d
https://doi.org/10.1080/18811248.2003.9715345
https://doi.org/10.1080/18811248.2003.9715345
Autor:
Masaaki Nakano, Kiyonobu Yamashita, Mituo Takeuchi, Naoki Nojiri, Shingo Fujisaki, Nozomu Fujimoto, Seiji Tamura
Publikováno v:
Journal of the Atomic Energy Society of Japan / Atomic Energy Society of Japan. 41:35-38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c503ad47b713fe7f0fe30dde5489e49
https://doi.org/10.3327/jaesj.41.35
https://doi.org/10.3327/jaesj.41.35
Autor:
Naoaki Matsuki, Kenichiro Ono, Takashi Onodera, Asako Takanohashi, Seiji Tamura, Makoto Bonkobara
Publikováno v:
Journal of Veterinary Medical Science. 60:63-69
To elucidate mechanisms of free radical-induced neuronal cell death, lipid peroxidation measured as thiobarbituric acid-reactive substances (TBARS), three antioxidative enzyme activities (superoxide dismutase, glutathione peroxidase, and catalse), an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56935d0801a7f9d799d5e64e09778be
https://doi.org/10.1292/jvms.60.63
https://doi.org/10.1292/jvms.60.63
Autor:
Yoshitsugu Shitaka, Seiji Tamura, Masamichi Okada, Atsuyuki Kohara, Shinichi Yatsugi, Shigeki Kawabata, Masayasu Takahashi, Satoshi Hayashibe
Publikováno v:
Brain research. 1191
We describe in vitro properties and in vivo neuroprotective effects of a newly synthesized, high-affinity, selective allosteric metabotropic glutamate receptor type 1 (mGluR(1)) antagonist, N-cyclohexyl-6-{[(2-methoxyethyl)(methyl)amino]methyl}-N-met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30db61881c49fb9a2081684d6724f17
https://pubmed.ncbi.nlm.nih.gov/18164695
https://pubmed.ncbi.nlm.nih.gov/18164695
Autor:
Yoshitsugu Shitaka, Yukinori Nagakura, Tetsuo Kiso, Takashi Toya, Tomonari Watabiki, Masamichi Okada, Atsuyuki Kohara, Hirotsune Itahana, Seiji Tamura
Publikováno v:
European journal of pharmacology. 571(1)
Metabotropic glutamate receptor 1 (mGlu 1 receptor) has been suggested to play an important role in pain transmission. In this study, the effects of a newly-synthesized mGlu 1 receptor antagonist, ( R )- N -cycloheptyl-6-({[(tetrahydro-2-furyl)methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185ac1b9c70bc00c55e8b89582953bd5
https://pubmed.ncbi.nlm.nih.gov/17597604
https://pubmed.ncbi.nlm.nih.gov/17597604
Autor:
Atsuhiko Hasegawa, Kenichiro Ono, Toshihiro Watari, Sigeyoshi Takagi, Naoaki Matsuki, Ryo Goitsuka, Seiji Tamura
Publikováno v:
Journal of Veterinary Medical Science. 53:717-719
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c86032a29815196f3fc9f09e60f34d0e
https://doi.org/10.1292/jvms.53.717
https://doi.org/10.1292/jvms.53.717