Zobrazeno 1 - 10
of 856
pro vyhledávání: '"Seiji NAKAMURA"'
Autor:
Lijing Yan, Yuka Miyahara, Mizuki Sakamoto, Naoki Kaneko, Hu Chen, Junsei Sameshima, Hajime Kido, Shiho Yokomizo, Tomoki Sueyoshi, Haruki Nagano, Yukiko Ohyama, Seiji Nakamura, Shintaro Kawano, Masafumi Moriyama
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundSjögren’s disease (SjD) is an autoimmune disease marked by lymphocytic infiltration of salivary and lacrimal glands, leading to glandular dysfunction, where CD4-positive helper T (Th) cells and their cytokines are crucial in the pathogen
Externí odkaz:
https://doaj.org/article/8166754468f7472f9f94f7afd45d778d
Publikováno v:
Japanese Dental Science Review, Vol 59, Iss , Pp 1-7 (2023)
(IgG4-RD) is an immune-mediated fibrotic disorder characterized by severe resolution of inflammation and dysregulation of wound healing. IgG4-RD has been considered a unique disease since 2003, and significant progress has been achieved in the unders
Externí odkaz:
https://doaj.org/article/10d9c36782b946a4ab13d0b6e9d01eed
Autor:
Yuka Miyahara, Hu Chen, Masafumi Moriyama, Keita Mochizuki, Naoki Kaneko, A. S. M. Rafiul Haque, Akira Chinju, Kazuki Kai, Mizuki Sakamoto, Noriko Kakizoe-Ishiguro, Masaki Yamauchi, Kenichi Ogata, Tamotsu Kiyoshima, Shintaro Kawano, Seiji Nakamura
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Oral lichen planus (OLP) is a chronic inflammatory disease associated with T cell infiltration. The crosstalk between oral epithelium and mucosal T cells was considered to be crucial in the pathogenesis of OLP. Here, we selectively extracted
Externí odkaz:
https://doaj.org/article/935a8d70adfb45f1bd3704f276984210
Autor:
Hu Chen, Junsei Sameshima, Shiho Yokomizo, Tomoki Sueyoshi, Haruki Nagano, Yuka Miyahara, Taiki Sakamoto, Shinsuke Fujii, Tamotsu Kiyoshima, Thomas Guy, Seiji Nakamura, Masafumi Moriyama, Naoki Kaneko, Shintaro Kawano
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundCancer immunotherapy targeting CD8+ T cells has made remarkable progress, even for oral squamous cell carcinoma (OSCC), a heterogeneous epithelial tumor without a substantial increase in the overall survival rate over the past decade. Howev
Externí odkaz:
https://doaj.org/article/6dfcb4d452f74bcb92b69749c60068b3
Autor:
Naoki Kaneko, Hu Chen, Cory A. Perugino, Takashi Maehara, Ryusuke Munemura, Shiho Yokomizo, Junsei Sameshima, Thomas J. Diefenbach, Katherine R. Premo, Akira Chinju, Yuka Miyahara, Mizuki Sakamoto, Masafumi Moriyama, John H. Stone, Seiji Nakamura, Shiv Pillai
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Sjögren’s syndrome is a chronic autoimmune disorder whose pathogenesis is poorly understood and that lacks effective therapies. Detailed quantitative and spatial analyses of tissues affected by Sjögren’s syndrome were undertaken, inclu
Externí odkaz:
https://doaj.org/article/6813e2fa2bbf4c22b51356c495070222
Autor:
Hugues Allard-Chamard, Naoki Kaneko, Alice Bertocchi, Na Sun, Julie Boucau, Hsiao-Hsuan Kuo, Jocelyn R. Farmer, Cory Perugino, Vinay S. Mahajan, Samuel J.H. Murphy, Katherine Premo, Thomas Diefenbach, Musie Ghebremichael, Grace Yuen, Alekhya Kotta, Zafer Akman, Mathias Lichterfeld, Bruce D. Walker, Xu G. Yu, Masafumi Moriyama, Takashi Maehara, Seiji Nakamura, John H. Stone, Robert F. Padera, Shiv Pillai
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112630- (2023)
Summary: Although therapeutic B cell depletion dramatically resolves inflammation in many diseases in which antibodies appear not to play a central role, distinct extrafollicular pathogenic B cell subsets that accumulate in disease lesions have hithe
Externí odkaz:
https://doaj.org/article/f6449a71ead94ed7a5350e782a784b4a
Autor:
Daisuke Minami, Nagio Takigawa, Yasuhiro Nakajima, Nobuaki Miyahara, Yasuyuki Mizumori, Mitsuhiro Ueda, Seiji Nakamura, Fumihiko Suzuki, Yoshiharu Sato, Kei Morikawa, Arihiko Kanehiro
Publikováno v:
Thoracic Cancer, Vol 13, Iss 11, Pp 1735-1738 (2022)
Abstract Here, we report a case of a pulmonary invasive mucinous adenocarcinoma harboring KRAS G12D, diagnosed from tumor samples containing a very small amount of tumor cells using next‐generation sequencing (NGS) and the recently developed Lung C
Externí odkaz:
https://doaj.org/article/776c21d1b0314ce1b5900e00d90e462c
Autor:
Tian Tian, Kanako Miyazaki, Yuta Chiba, Keita Funada, Tomomi Yuta, Kanji Mizuta, Yao Fu, Jumpei Kawahara, Xue Han, Yuna Ando, Ami Funada, Aya Yamada, Tsutomu Iwamoto, Seiji Nakamura, Ichiro Takahashi, Satoshi Fukumoto, Keigo Yoshizaki
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Development of chemotherapy has led to a high survival rate of cancer patients; however, the severe side effects of anticancer drugs, including organ hypoplasia, persist. To assume the side effect of anticancer drugs, we established a new ex
Externí odkaz:
https://doaj.org/article/5ee8772b55b244938fbece62a21f02ff
Publikováno v:
Immuno, Vol 2, Iss 1, Pp 170-184 (2022)
This review summarizes recent progress in understanding the pathogenesis of IgG4-related disease (IgG4-RD), with a focus on fibrosis. Several studies reported that CD4+ T cells with cytotoxic activity promoted by the secretion of granzyme and perfori
Externí odkaz:
https://doaj.org/article/ea114c33fcdb4f2ba296ee265d1f4b09
Autor:
Kei Morikawa, Hiroshi Handa, Junko Ueno, Hajime Tsuruoka, Takeo Inoue, Naoki Shimada, Junki Koike, Seiji Nakamura, Yoshiharu Sato, Masamichi Mineshita
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Personalized medicine using molecular-targeted drugs to achieve better therapeutic response and long-term prognosis is common practice for lung cancer treatment. However, in cases before gene batch tests were available, medical treatment continued wi
Externí odkaz:
https://doaj.org/article/b35eccb4ac88451ca4ff253309612c9f