Zobrazeno 1 - 10
of 253
pro vyhledávání: '"Seiji Matsuda"'
Autor:
Toshihide Takeuchi, Kazuhiro Maeta, Xin Ding, Yukako Oe, Akiko Takeda, Mana Inoue, Seiichi Nagano, Tsuyoshi Fujihara, Seiji Matsuda, Shinsuke Ishigaki, Kentaro Sahashi, Eiko N. Minakawa, Hideki Mochizuki, Masahiro Neya, Gen Sobue, Yoshitaka Nagai
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 353-366 (2023)
The abnormal aggregation of TDP-43 into cytoplasmic inclusions in affected neurons is a pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although how TDP-43 forms cytoplasmic aggregates and causes neurod
Externí odkaz:
https://doaj.org/article/e9b6e963c4c34b85be2d7b931b43c025
Autor:
Sakirul Khan, Akihide Takeuchi, Hiroaki Nabeka, Farzana Khan, Tetsuya Shimokawa, Sota Takanezawa, Takashi Saitou, Takeshi Imamura, Tetsuya Tachibana, Akira Nishizono, Fumihiko Hamada, Seiji Matsuda
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106277- (2023)
Summary: Neural tube defects (NTDs) cause fetal and pediatric deaths or lifelong neurological disabilities. No effective treatment is currently available for NTDs. We attempted to elucidate the pathogenesis of NTDs and propose a therapeutic strategy.
Externí odkaz:
https://doaj.org/article/128380307a99435e8ad3e3918d24e6fe
Publikováno v:
Frontiers in Neural Circuits, Vol 16 (2022)
The marmoset (a New World monkey) has recently received much attention as an experimental animal model; however, little is known about the connectivity of limbic regions, including cortical and hippocampal memory circuits, in the marmoset. Here, we i
Externí odkaz:
https://doaj.org/article/d732d34e750e4569bf0e9be93082e0a3
Autor:
Md. Sarikul Khan, Hiroaki Nabeka, Farzana Islam, Tetsuya Shimokawa, Shouichiro Saito, Tetsuya Tachibana, Seiji Matsuda
Publikováno v:
Folia Neuropathologica, Vol 58, Iss 2, Pp 151-165 (2020)
Spina bifida aperta (SBA), one of the most common congenital malformations, causes various neurological disorders. Pain is a common complaint of patients with SBA. However, little is known about the neuropathology of SBA-related pain. Because loss of
Externí odkaz:
https://doaj.org/article/f3179472f7484e3a8f6b723afabd8389
Autor:
Miho Taniguchi, Hiroaki Nabeka, Kimiko Yamamiya, Md. Sakirul Islam Khan, Tetsuya Shimokawa, Farzana Islam, Takuya Doihara, Hiroyuki Wakisaka, Naoto Kobayashi, Fumihiko Hamada, Seiji Matsuda
Publikováno v:
PLoS ONE, Vol 16, Iss 8 (2021)
Prosaposin (PSAP), a highly conserved glycoprotein, is a precursor of saposins A–D. Accumulating evidence suggests that PSAP is a neurotrophic factor, as well as a regulator of lysosomal enzymes. Recently, the orphan G-protein-coupled receptors GPR
Externí odkaz:
https://doaj.org/article/20ef7b8059134570aa9251289a0ad181
Autor:
Joji Kunihiro, Hiroaki Nabeka, Hiroyuki Wakisaka, Kana Unuma, Md Sakirul Islam Khan, Tetsuya Shimokawa, Farzana Islam, Takuya Doihara, Kimiko Yamamiya, Shouichiro Saito, Fumihiko Hamada, Seiji Matsuda
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0241315 (2020)
Neurotrophic factor prosaposin (PS) is a precursor for saposins A, B, C, and D, which are activators for specific sphingolipid hydrolases in lysosomes. Both saposins and PS are widely contained in various tissues. The brain, skeletal muscle, and hear
Externí odkaz:
https://doaj.org/article/40d0edceabf2430981d08681f2bf6ae1
Autor:
Junpei Suzuki, Takeshi Yamada, Kazuki Inoue, Shogo Nabe, Makoto Kuwahara, Nobuaki Takemori, Ayako Takemori, Seiji Matsuda, Makoto Kanoh, Yuuki Imai, Masaki Yasukawa, Masakatsu Yamashita
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
T cells can alter their metabolism during activation and differentiation. Here the authors show that the tumor suppressor menin regulates CD8 T-cell fate via the modulation of central carbon metabolism.
Externí odkaz:
https://doaj.org/article/ab20cf83169f418bb4198a412fbc757d
Autor:
Md. Sakirul Islam Khan, Hiroaki Nabeka, Farzana Islam, Tetsuya Shimokawa, Shouichiro Saito, Xuan Li, Soichiro Kawabe, Fumihiko Hamada, Tetsuya Tachibana, Seiji Matsuda
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 12, Pp 1421-1432 (2017)
Spina bifida aperta (SBA), one of the most common congenital malformations, causes lifelong neurological complications, particularly in terms of motor dysfunction. Fetuses with SBA exhibit voluntary leg movements in utero and during early neonatal li
Externí odkaz:
https://doaj.org/article/ba42dc8c321f4ad3afa6d3f7c05f30b8
Autor:
Hiroaki Nabeka, Shouichiro Saito, Xuan Li, Tetsuya Shimokawa, Md. Sakirul Islam Khan, Kimiko Yamamiya, Soichiro Kawabe, Takuya Doihara, Fumihiko Hamada, Naoto Kobayashi, Seiji Matsuda
Publikováno v:
IBRO Reports, Vol 3, Iss C, Pp 17-32 (2017)
Prosaposin (PS) is a secretory neurotrophic factor, as well as a regulator of lysosomal enzymes. We previously reported the up-regulation of PS and the possibility of its axonal transport by GABAergic interneurons after exocitotoxicity induced by kai
Externí odkaz:
https://doaj.org/article/dca0b656cfbd4cde9465e2f69ace2202
Autor:
Xuan Li, Hiroaki Nabeka, Shouichiro Saito, Tetsuya Shimokawa, Md. Sakirul Islam Khan, Kimiko Yamamiya, Fengping Shan, Huiling Gao, Cheng Li, Seiji Matsuda
Publikováno v:
IBRO Reports, Vol 2, Iss C, Pp 31-40 (2017)
Prosaposin (PSAP), a highly conserved glycoprotein, is a precursor of saposins A–D. Accumulating evidence suggests that PSAP is a neurotrophic factor that induces differentiation and prevents death in a variety of neuronal cells through the active
Externí odkaz:
https://doaj.org/article/92ff811eb3d143c58d6dc842476d485f