Výsledky vyhledávání - "Seiji Kawashita"

SAR study of small molecule inhibitors of the programmed cell death‐1/programmed cell death‐ligand 1 interaction

Autor: Kyoko Fukushima, Rie Hantani, Shiori Naruoka, Yukiyo Toyonaga, Yuji Hori, Koichi Aoyagi, Hiroshi Yamanaka, Susumu Miyazaki, Atsuo Tanimoto, Seiji Kawashita, Yoshiji Hantani

Publikováno v: Chemical Biology & Drug Design. 98:914-929

The development of small molecule inhibitors of programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) has drawn research interest for the treatment of cancer. Recently, we reported the discovery of a novel dimeric core small molecule PD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901084d28a5ea32c80e28dbe5751de50
https://doi.org/10.1111/cbdd.13949

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Symmetry-based ligand design and evaluation of small molecule inhibitors of programmed cell death-1/programmed death-ligand 1 interaction

Autor: Rie Hantani, Kyoko Fukushima, Koichi Aoyagi, Yukiyo Toyonaga, Hiroshi Yamanaka, Yuji Hori, Seiji Kawashita, Shiori Naruoka, Yoshiji Hantani, Susumu Miyazaki, Atsuo Tanimoto

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 29:2464-2467

The development of small molecule inhibitors of PD-1/PD-L1 is eagerly anticipated for treatment of cancer. We focused on the symmetry of the ternary complex structure of reported small molecule ligands and hPD-L1 homodimers, and designed partially- o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7621b57dcb425686500ccc5ebc1134
https://doi.org/10.1016/j.bmcl.2019.07.027

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Effect of Allylic CH3-nFn Groups (n = 1−3) on π-Facial Diastereoselection

Autor: Satoshi Takei, Tatsuro Ichige, Toshio Kubota, Seiji Kawashita, Tomoya Kitazume, Takashi Yamazaki

Publikováno v: Organic Letters. 3:2915-2918

[structure: see text]. Michael addition of various enolates toward gamma-CH(3-n)F(n)-alpha,beta-unsaturated ketones (n = 1-3) was proven to smoothly furnish the 1,4-adducts with high si face selectivities which monotonously decreased by reduction in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37133ae4d1b0811616781eef1377aefc
https://doi.org/10.1021/ol016401g

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