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Akademický článek

Identification of the p-coumaric acid biosynthetic gene cluster in Kutzneria albida: insights into the diazotization-dependent deamination pathway

Autor: Seiji Kawai, Akito Yamada, Yohei Katsuyama, Yasuo Ohnishi

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 1-11 (2024)

Recently, we identified the biosynthetic gene cluster of avenalumic acid (ava cluster) and revealed its entire biosynthetic pathway, resulting in the discovery of a diazotization-dependent deamination pathway. Genome database analysis revealed the pr

Externí odkaz: https://doaj.org/article/ae3a9d372add4c3abd52724ad25fe897

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Akademický článek

Localization of oxidized low-density lipoprotein and its relation to plaque morphology in human coronary artery.

Autor: Yasumi Uchida, Yuko Maezawa, Yasuto Uchida, Nobuyuki Hiruta, Ei Shimoyama, Seiji Kawai

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e55188 (2013)

OBJECTIVES: Oxidized low-density lipoprotein (oxLDL) plays a key role in the formation of atherosclerotic plaques. However, its localization in human coronary arterial wall is not well understood. The present study was performed to visualize depositi

Externí odkaz: https://doaj.org/article/0f1dba87265e4431bba235f35a7621ad

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Bacterial Avenalumic Acid Biosynthesis Includes Substitution of an Aromatic Amino Group for Hydride by Nitrous Acid Dependent Diazotization

Autor: Seiji Kawai, Ryota Hagihara, Kazuo Shin‐ya, Yohei Katsuyama, Yasuo Ohnishi

Publikováno v: Angewandte Chemie. 134

The diazo group is an important functional group that can confer biological activity to natural products owing to its high reactivity. Recent studies have revealed that diazo groups are synthesized from amino groups using nitrous acid in secondary me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b305cd92cfdae365ad6ca51893ad6e
https://doi.org/10.1002/ange.202211728

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Structural and Functional Analyses of the Tridomain‐Nonribosomal Peptide Synthetase FmoA3 for 4‐Methyloxazoline Ring Formation

Autor: Kazuo Shin-ya, Yohei Katsuyama, Yasuo Ohnishi, Kaoru Sone, Toshio Moriya, Seiji Kawai, Ayaka Harada, Naoki Urano, Toshiya Senda, Masato Kawasaki, Naruhiko Adachi

Publikováno v: Angewandte Chemie International Edition. 60:14554-14562

Nonribosomal peptide synthetases (NRPSs) are attractive targets for bioengineering to generate useful peptides . F moA3 is a single modular NRPS composed of heterocyclization (Cy), adenylation (A), and peptidyl carrier protein (PCP) domains. It use s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6baf66acaacf62d25832f6872199d2f2
https://doi.org/10.1002/anie.202102760

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The α/β Hydrolase AzpM Catalyzes Dipeptide Synthesis in Alazopeptin Biosynthesis Using Two Molecules of Carrier Protein-Tethered Amino Acid

Autor: Seiji Kawai, Yohei Katsuyama, Yasuo Ohnishi

Publikováno v: Chembiochem : a European journal of chemical biology. 23(7)

During the biosynthesis of alazopeptin, a tripeptide composed of two molecules of 6-diazo-5-oxo-L-norleucine (DON) and one of alanine, the α/β hydrolase AzpM synthesizes the DON-DON dipeptide using DON tethered to the carrier protein AzpF (DON-AzpF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94c8e5f082243cd8b96be1543c31743
https://pubmed.ncbi.nlm.nih.gov/35132756

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