Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Seiji Hitoshi"'
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2024)
Externí odkaz:
https://doaj.org/article/4bbdff0ab46747c79b2129851a8d3a0a
Publikováno v:
Journal of Physiological Sciences, Vol 73, Iss 1, Pp 1-9 (2023)
Abstract Neural stem cells (NSCs) are maintained in the adult mammalian brain throughout the animal’s lifespan. NSCs in the subependymal zone infrequently divide and generate transit amplifying cells, which are destined to become olfactory bulb neu
Externí odkaz:
https://doaj.org/article/3afe810d9d804ff691a0a97565097b34
Autor:
Seiya Oura, Taichi Noda, Naoko Morimura, Seiji Hitoshi, Hiroshi Nishimasu, Yoshitaka Nagai, Osamu Nureki, Masahito Ikawa
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Seiya Oura and Taichi Noda et al. overcome the challenge of gene editing in CAG repeats, such as those causing Huntington’s Disease, using their recently developed SpCas9-NG variant. They demonstrate that SpCas9-NG can precisely edit and contract t
Externí odkaz:
https://doaj.org/article/6b8b24cc62624b4fbbeec478f8cf925c
Autor:
Kenny Anak Daun, Takahiro Fuchigami, Natsu Koyama, Noriko Maruta, Kazuhiro Ikenaka, Seiji Hitoshi
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Early life stress can exert detrimental or beneficial effects on neural development and postnatal behavior depending on the timing, duration, strength, and ability to control the stressors. In this study, we utilized a maternal and social deprivation
Externí odkaz:
https://doaj.org/article/1fccdc3e57a640cfb726a3035b0a3435
Autor:
Asmaa Abdullah, Yoshitaka Hayashi, Naoko Morimura, Akhilesh Kumar, Kazuhiro Ikenaka, Akira Togayachi, Hisashi Narimatsu, Seiji Hitoshi
Publikováno v:
Neurochemical Research. 47:2793-2804
α1,3-Fucosyltransferase 9 (Fut9) is responsible for the synthesis of Lewis X [LeX, Galβ1-4(Fucα1-3)GlcNAc] carbohydrate epitope, a marker for pluripotent or multipotent tissue-specific stem cells. Although Fut9-deficient mice show anxiety-related
Autor:
Aoi Tanaka, Takahiro Fuchigami, Seiji Hitoshi, Shohei Ishida, Anri Kuroda, Yoshitaka Hayashi, Yugo Fukazawa, Kazuhiro Ikenaka
Publikováno v:
Cerebral cortex (New York, N.Y. : 1991). 30(12):6415-6425
The origin and life-long fate of quiescent neural stem cells (NSCs) in the adult mammalian brain remain largely unknown. A few neural precursor cells in the embryonic brain elongate their cell cycle time and subsequently become quiescent postnatally,
Publikováno v:
Journal of Neurochemistry. 147:584-594
In the adult mammalian brain, neural stem cells (NSCs) reside in two neurogenic regions, the walls of the lateral ventricles, and the subgranular zone of the hippocampus, which generate new neurons for the olfactory bulb and dentate gyrus, respective
Publikováno v:
Neurochemical Research. 43:219-226
Minocycline not only has antibacterial action but also produces a variety of pharmacological effects. It has drawn considerable attention as a therapeutic agent for symptoms caused by inflammation in many neurological disorders, leading to several cl
Autor:
Yasunari Seita, Kenichi Kobayashi, Shinichiro Nakamura, Masataka Nakaya, Tomoyuki Tsukiyama, Takuya Azami, Seiji Hitoshi, Hideaki Tsuchiya, Hideyuki Tanabe, Masatsugu Ema, Akihiro Kawauchi, Chizuru Iwatani, Hiroyuki Miyoshi
Publikováno v:
Biology of reproduction. 100(6)
Nonhuman primates (NHPs) are considered to be the most valuable models for human transgenic (Tg) research into disease, because human pathology is more closely recapitulated in NHPs than rodents. Previous studies have reported the generation of Tg NH
Autor:
Masahiro Yamaguchi, Itaru Imayoshi, Nobuaki Tamamaki, Yoshitaka Hayashi, Yoshitaka Tatebayashi, Tatsunori Seki, Seiji Hitoshi
Publikováno v:
The Journal of Physiological Sciences
Neurons and glia in the central nervous system (CNS) originate from neural stem cells (NSCs). Knowledge of the mechanisms of neuro/gliogenesis from NSCs is fundamental to our understanding of how complex brain architecture and function develop. NSCs