Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Seiichi NAGANO"'
Autor:
Tetsuhiro Ueda, Toshihide Takeuchi, Nobuhiro Fujikake, Mari Suzuki, Eiko N. Minakawa, Morio Ueyama, Yuzo Fujino, Nobuyuki Kimura, Seiichi Nagano, Akio Yokoseki, Osamu Onodera, Hideki Mochizuki, Toshiki Mizuno, Keiji Wada, Yoshitaka Nagai
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-15 (2024)
Abstract The abnormal aggregation of TDP-43 into cytoplasmic inclusions in affected neurons is a major pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although TDP-43 is aberrantly accumulated in the ne
Externí odkaz:
https://doaj.org/article/01c84c3ce0384f509847436ec4ff47eb
Autor:
Toshihide Takeuchi, Kazuhiro Maeta, Xin Ding, Yukako Oe, Akiko Takeda, Mana Inoue, Seiichi Nagano, Tsuyoshi Fujihara, Seiji Matsuda, Shinsuke Ishigaki, Kentaro Sahashi, Eiko N. Minakawa, Hideki Mochizuki, Masahiro Neya, Gen Sobue, Yoshitaka Nagai
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 353-366 (2023)
The abnormal aggregation of TDP-43 into cytoplasmic inclusions in affected neurons is a pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although how TDP-43 forms cytoplasmic aggregates and causes neurod
Externí odkaz:
https://doaj.org/article/e9b6e963c4c34b85be2d7b931b43c025
Autor:
Haomin Yan, Tsutomu Sasaki, Hideaki Kanki, Yoshiyuki Hirata, Kumiko Nishiyama, Sunao Hisada, Shigenobu Matsumura, Yasuo Nagaoka, Takaaki Sumiyoshi, Seiichi Nagano, Akiko Nakata, Minoru Yoshida, Shinichi Uesato, Hideki Mochizuki
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Mdmx and Mdm2 are two major suppressor factors for the tumor suppressor gene p53. In central nervous system, Mdmx suppresses the transcriptional activity of p53 and enhances the binding of Mdm2 to p53 for degradation. But Mdmx dynamics in ce
Externí odkaz:
https://doaj.org/article/d535ef55554745bdb1de765b94ef736c
Autor:
Makoto Hideshima, Yasuyoshi Kimura, César Aguirre, Keita Kakuda, Toshihide Takeuchi, Chi-Jing Choong, Junko Doi, Kei Nabekura, Keiichi Yamaguchi, Kichitaro Nakajima, Kousuke Baba, Seiichi Nagano, Yuji Goto, Yoshitaka Nagai, Hideki Mochizuki, Kensuke Ikenaka
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Parkinson’s disease is a neurodegenerative disease characterized by the formation of neuronal inclusions of α-synuclein in patient brains. As the disease progresses, toxic α-synuclein aggregates transmit throughout the nervous system. No
Externí odkaz:
https://doaj.org/article/480865b6dc8d4cbda2fe0989319f86ac
Autor:
Shotaro Haji, Koji Fujita, Ryosuke Oki, Yusuke Osaki, Ryosuke Miyamoto, Hiroyuki Morino, Seiichi Nagano, Naoki Atsuta, Yuki Kanazawa, Yuki Matsumoto, Atsuko Arisawa, Hisashi Kawai, Yasutaka Sato, Satoshi Sakaguchi, Kenta Yagi, Tatsuto Hamatani, Tatsuo Kagimura, Hiroaki Yanagawa, Hideki Mochizuki, Manabu Doyu, Gen Sobue, Masafumi Harada, Yuishin Izumi
Publikováno v:
JMIR Research Protocols, Vol 12, p e42032 (2023)
BackgroundAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, with its currently approved drugs, including riluzole and edaravone, showing limited therapeutic effects. Therefore, safe and effective drugs are urgently necessary.
Externí odkaz:
https://doaj.org/article/5bcf8cf20c5741ca83d7aded83f2f34c
Autor:
Mitsuru Shinohara, Masataka Kikuchi, Miyuki Onishi‐Takeya, Yoshitaka Tashiro, Kaoru Suzuki, Yasuhiro Noda, Shuko Takeda, Masahiro Mukouzono, Seiichi Nagano, Akio Fukumori, Ryuichi Morishita, Akihiro Nakaya, Naoyuki Sato
Publikováno v:
FASEB BioAdvances, Vol 3, Iss 5, Pp 323-333 (2021)
Abstract Clinical studies have indicated that obesity and diabetes are associated with Alzheimer's disease (AD) and neurodegeneration. However, the mechanism by which obesity/diabetes and AD interact with each other and contribute to dementia remains
Externí odkaz:
https://doaj.org/article/14add0dde46f4712afdc24c83ff4af10
Autor:
Rehab F. Abdelhamid, Seiichi Nagano
Publikováno v:
Cells, Vol 12, Iss 5, p 753 (2023)
The world population is aging rapidly, and increasing lifespan exacerbates the burden of age-related health issues. On the other hand, premature aging has begun to be a problem, with increasing numbers of younger people suffering aging-related sympto
Externí odkaz:
https://doaj.org/article/e5b2d72b766341c18916c85b7b8f754d
Autor:
Mougina K Eltahir, Masayuki Nakamori, Satoshi Hattori, Takashi Kimura, Hideki Mochizuki, Seiichi Nagano
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0269683 (2022)
Myotonic dystrophy type 1 (DM1) is a trinucleotide repeat disorder affecting multiple organs. However, most of the research is focused on studying and treating its muscular symptoms. On the other hand, despite the significant impact of the neurologic
Externí odkaz:
https://doaj.org/article/aafcb837e7d9437b9e9a61d7b57dc1a5
Autor:
Seiichi Nagano, Toshiyuki Araki
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Since neurons have long neurites including axons, it is crucial for the axons to transport many intracellular substances such as proteins and mitochondria in order to maintain their morphology and function. In addition, mRNAs have also been shown to
Externí odkaz:
https://doaj.org/article/a57ff7fed55441b6bebb2b779deb61c2
Autor:
Chi-Jing Choong, César Aguirre, Keita Kakuda, Goichi Beck, Hiroki Nakanishi, Yasuyoshi Kimura, Shuichi Shimma, Kei Nabekura, Makoto Hideshima, Junko Doi, Keiichi Yamaguchi, Kichitaro Nakajima, Tomoya Wadayama, Hideki Hayakawa, Kousuke Baba, Kotaro Ogawa, Toshihide Takeuchi, Shaymaa Mohamed Mohamed Badawy, Shigeo Murayama, Seiichi Nagano, Yuji Goto, Yohei Miyanoiri, Yoshitaka Nagai, Hideki Mochizuki, Kensuke Ikenaka
Publikováno v:
Acta Neuropathologica. 145:573-595
Lipid interaction with α-synuclein (αSyn) has been long implicated in the pathogenesis of Parkinson’s disease (PD). However, it has not been fully determined which lipids are involved in the initiation of αSyn aggregation in PD. Here exploiting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fe152b5d0a194e8eb6d5afedcc674a7
https://doi.org/10.1007/s00401-023-02555-3
https://doi.org/10.1007/s00401-023-02555-3