Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Seiichi Kobashi"'
Autor:
Kazuki Kawakami, Masaki Ohya, Mitsuru Yashiro, Tomohiro Sonou, Shuto Yamamoto, Yuri Nakashima, Takuro Yano, Yusuke Tanaka, Koichi Ishida, Seiichi Kobashi, Takashi Shigematsu, Shin-ichi Araki
Publikováno v:
Calcified Tissue International.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17dc7c6ba37cdbc668574de0685eda9a
https://doi.org/10.1007/s00223-023-01086-z
https://doi.org/10.1007/s00223-023-01086-z
Autor:
Kengo Miyata, Takashi Iwanaga, Koichi Omura, Keisuke Motoki, Seiichi Kobashi, Katsuhiro Yamano
Publikováno v:
Drug Metabolism and Disposition. 49:1016-1024
Dotinurad, a novel selective urate reabsorption inhibitor, is used to treat hyperuricemia. In humans, orally administered dotinurad is excreted mainly as glucuronide and sulfate conjugates in urine. To identify the isoforms of UDP-glucuronosyltransfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2cadb59a775aa39567610b9d0e0b55
https://doi.org/10.1124/dmd.120.000251
https://doi.org/10.1124/dmd.120.000251
Autor:
Junichiro Uda, Tomomitsu Sasaki, Seiichi Kobashi, Takashi Iwanaga, Masahiko Fushimi, Tetsuo Ohashi, Azusa Ito, Kengo Miyata, Koichi Omura
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:313-320
Dotinurad, a novel selective urate reabsorption inhibitor (SURI), has potent inhibitory effects at low doses on the uptake of urate by urate transporter 1 (URAT1, solute carrier family 22 member 12 [SLC22A12]), localized at the apical membrane of ren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0997f6717f192b86434b9b73b894e0ea
https://doi.org/10.1016/j.dmpk.2020.03.002
https://doi.org/10.1016/j.dmpk.2020.03.002
Publikováno v:
Bioorganicmedicinal chemistry letters. 40
Although benzbromarone (BBR) is a conventional, highly potent uricosuric drug, it is not a standard medicine because it causes rare but fatal fulminant hepatitis. We transformed the bis-aryl ketone structure of BBR to generate novel monocyclic amide-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f0cab0eed422b64cc348296700cb2e4
https://pubmed.ncbi.nlm.nih.gov/33684442
https://pubmed.ncbi.nlm.nih.gov/33684442
Autor:
Seiichi Kobashi, Naoki Ashizawa, Ishida Koichi, Takashi Iwanaga, Shota Morikane, Naoki Kurita
Publikováno v:
The Journal of pharmacy and pharmacology. 73(7)
Objective Ectopic calcification such as vascular calcification, involves the formation of calciprotein particle (CPP), that is, colloidal particle of calcium phosphate bound to serum protein. In this study, a novel parameter for CPP formation was int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c4f5549325c78273828036c66040c8
https://pubmed.ncbi.nlm.nih.gov/33882129
https://pubmed.ncbi.nlm.nih.gov/33882129
Autor:
Junichiro Uda, Takashi Iwanaga, Sachiho Miyata, Naoki Ashizawa, Seiichi Kobashi, Koji Matsumoto
Publikováno v:
ACS Med Chem Lett
[Image: see text] To derive new uricosuric agents, novel phenol derivatives were synthesized to overcome the disadvantages of benzbromarone (BBR), attributed by its structural features. Herein, we report the discovery of new phenol derivatives with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e374e8be094fc9a5b5103b0a94a62435
https://pubmed.ncbi.nlm.nih.gov/33062187
https://pubmed.ncbi.nlm.nih.gov/33062187
Autor:
Koichi Ishida, Naoki Ashizawa, Shota Morikane, Naoki Kurita, Seiichi Kobashi, Takashi Iwanaga
Publikováno v:
Journal of Pharmacy & Pharmacology; Jul2021, Vol. 73 Issue 7, p947-955, 9p
Autor:
Takashi Iwanaga, Ishida Koichi, Koji Matsumoto, Naoki Kurita, Takashi Shigematsu, Naoki Ashizawa, Seiichi Kobashi
Publikováno v:
Journal of bone and mineral metabolism. 37(5)
In patients with chronic kidney disease (CKD) or those undergoing hemodialysis, pathological calcific deposition known as ectopic calcification occurs in soft tissue, resulting in a life-threatening disorder. A potent and effective inhibitor of ectop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568217b8d48c60fdd3554a5a383d88f3
https://pubmed.ncbi.nlm.nih.gov/30712064
https://pubmed.ncbi.nlm.nih.gov/30712064
Publikováno v:
Biological and Pharmaceutical Bulletin. 26:375-379
N-Acyloctahydropyrido[3,2,1-ij][1,6]naphthyridines were synthesized as derivatives of matrine-type alkaloids, and the structure-activity relations were examined by the acetic acid-induced abdominal contraction test. The antinociceptive potencies of N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e489549ec94942003ed5db773159f2b0
https://doi.org/10.1248/bpb.26.375
https://doi.org/10.1248/bpb.26.375
Publikováno v:
Biological and Pharmaceutical Bulletin. 25:1030-1034
We previously reported that (+)-matrine and (+)-allomatrine have antinociceptive properties mediated mainly through the activation of kappa-opioid receptors. 1-Acyl-4-dialkylaminopiperidines were synthesized as the simplest derivatives of matrine, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab021395d434711fdbc91c98225c176
https://doi.org/10.1248/bpb.25.1030
https://doi.org/10.1248/bpb.25.1030