Zobrazeno 1 - 10 of 60 pro vyhledávání: '"Seiichi Chiba"'
1
Akademický článek
Glucagon-like peptide-1 reduces pancreatic β-cell mass through hypothalamic neural pathways in high-fat diet-induced obese rats
Autor: Hisae Ando, Koro Gotoh, Kansuke Fujiwara, Manabu Anai, Seiichi Chiba, Takayuki Masaki, Tetsuya Kakuma, Hirotaka Shibata
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract We examined whether glucagon-like peptide-1 (GLP-1) affects β-cell mass and proliferation through neural pathways, from hepatic afferent nerves to pancreatic efferent nerves via the central nervous system, in high-fat diet (HFD)-induced obe
Externí odkaz: https://doaj.org/article/dab5c77c27d44ed69d94ef46c06ed68f
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2
Akademický článek
A clinical approach to brown adipose tissue in the para-aortic area of the human thorax.
Autor: Huixing Wei, Seiichi Chiba, Chinatsu Moriwaki, Hirokazu Kitamura, Keisuke Ina, Taishi Aosa, Kenichiro Tomonari, Koro Gotoh, Takayuki Masaki, Isao Katsuragi, Hitoshi Noguchi, Tetsuya Kakuma, Kazuyuki Hamaguchi, Tatsuo Shimada, Yoshihisa Fujikura, Hirotaka Shibata
Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0122594 (2015)
BACKGROUND:Human thoracic brown adipose tissue (BAT), composed of several subdivisions, is a well-known target organ of many clinical studies; however, the functional contribution of each part of human thoracic BAT remains unknown. The present study
Externí odkaz: https://doaj.org/article/3166eaca094d4d1baac632a5d4b020a6
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3
Akademický článek
The dipeptidyl peptidase-4 inhibitor des-fluoro-sitagliptin regulates brown adipose tissue uncoupling protein levels in mice with diet-induced obesity.
Autor: Takanobu Shimasaki, Takayuki Masaki, Kimihiko Mitsutomi, Daisuke Ueno, Koro Gotoh, Seiichi Chiba, Tetsuya Kakuma, Hironobu Yoshimatsu
Publikováno v: PLoS ONE, Vol 8, Iss 5, p e63626 (2013)
Dipeptidyl peptidase (DPP)-4 is responsible for the degradation of several peptides that contain an alanine or proline at the penultimate position or position P1. DPP-4 inhibitors (DPP-4is) have protective effects against type-2 diabetes and several
Externí odkaz: https://doaj.org/article/db3005da470746fc828117c3999a478e
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4
Akademický článek
Spleen-derived interleukin-10 downregulates the severity of high-fat diet-induced non-alcoholic fatty pancreas disease.
Autor: Koro Gotoh, Megumi Inoue, Kentaro Shiraishi, Takayuki Masaki, Seiichi Chiba, Kimihiko Mitsutomi, Takanobu Shimasaki, Hisae Ando, Kansuke Fujiwara, Isao Katsuragi, Tetsuya Kakuma, Masataka Seike, Toshiie Sakata, Hironobu Yoshimatsu
Publikováno v: PLoS ONE, Vol 7, Iss 12, p e53154 (2012)
Obesity is associated with systemic low-grade inflammation and is a risk factor for non-alcoholic fatty pancreas disease (NAFPD), but the molecular mechanisms of these associations are not clear. Interleukin (IL)-10, a potent anti-inflammatory cytoki
Externí odkaz: https://doaj.org/article/8e0a1bb19c384707a34250de4efb98a8
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5
Akademický článek
Neurodegenerative evidence in mice brains with cecal ligation and puncture-induced sepsis: preventive effect of the free radical scavenger edaravone.
Autor: Hiroki Yokoo, Seiichi Chiba, Kengo Tomita, Michinori Takashina, Hiroshi Sagara, Saburo Yagisita, Yasuo Takano, Yuichi Hattori
Publikováno v: PLoS ONE, Vol 7, Iss 12, p e51539 (2012)
Sepsis is a major clinical challenge and septic encephalopathy is its nasty complication. The pathogenesis and underlying mechanisms of septic encephalopathy are not well understood. This study sought to fully characterize sepsis-associated biochemic
Externí odkaz: https://doaj.org/article/9521003cc2b246558c25f8cdfe7234c2
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7
Effects of Sleeve Gastrectomy on Blood Pressure and the Renal Renin–Angiotensin System in Rats with Diet‐Induced Obesity
Autor: Akiko Kudo, Takashi Ozaki, Hirotaka Shibata, Koro Gotoh, Yoshinori Ozeki, Masanori Tokoro, Mitsuhiro Okamoto, Seiichi Chiba, Kiminori Watanabe, Yuichi Yoshida, Takayuki Masaki, Masayuki Ohta, Masafumi Inomata
Publikováno v: Obesity.
OBJECTIVE Sleeve gastrectomy (SG) has been reported to decrease blood pressure (BP), although the reason has not been revealed. The present study aimed to establish the reason why SG decreases BP. METHODS Male Sprague-Dawley rats were subjected to su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e73271756c06a5818d3eee9ffc1e2a3
https://doi.org/10.1002/oby.22443
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9
The signal pathway for the repressive effect of dipyridamole on myofibroblast transdifferentiation
Autor: Shuji Tatsukawa, Keisuke Ina, Huixing Wei, Seiichi Chiba, Yoshihisa Fujikura, Qiong Yan
Publikováno v: Journal of Cellular and Molecular Medicine
Renal fibrosis is the common final pathway of various chronic kidney diseases (CKDs), irrespective of the initial causes of nephropathy. Decline of renal function, glomerular filtration rate, has been exhibited to be highly associated with the progre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113c23ea7744332f5717a2c767d1d603
https://pubmed.ncbi.nlm.nih.gov/30451359
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10
Glucagon-like peptide-1 reduces pancreatic β-cell mass through hypothalamic neural pathways in high-fat diet-induced obese rats
Autor: Manabu Anai, Takayuki Masaki, Hisae Ando, Kansuke Fujiwara, Tetsuya Kakuma, Hirotaka Shibata, Koro Gotoh, Seiichi Chiba
Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
We examined whether glucagon-like peptide-1 (GLP-1) affects β-cell mass and proliferation through neural pathways, from hepatic afferent nerves to pancreatic efferent nerves via the central nervous system, in high-fat diet (HFD)-induced obese rats.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c242aad11c8bcb45d02fbdea1d79e5c
https://doi.org/10.1038/s41598-017-05371-4
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