Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Seigo Usuki"'
Autor:
Seigo Usuki, Noriko Tamura, Tomohiro Tamura, Shigeki Higashiyama, Kunikazu Tanji, Susumu Mitsutake, Asuka Inoue, Junken Aoki, Katsuyuki Mukai, Yasuyuki Igarashi
Publikováno v:
Biochemistry and Biophysics Reports, Vol 17, Iss , Pp 132-138 (2019)
Previously, we proposed the following mechanism for konjac ceramide (kCer)-mediated neurite outgrowth inhibition: kCer binds to Nrp as a Sema3A agonist, resulting in Nrp1/PlexA complex formation and activation of the Sema3A signaling pathway to induc
Externí odkaz:
https://doaj.org/article/835577ace0db4a7ca050f7661c6f0a7a
Autor:
Seigo Usuki, Noriko Tamura, Tomohiro Tamura, Kohei Yuyama, Daisuke Mikami, Katsuyuki Mukai, Yasuyuki Igarashi
Publikováno v:
Biology, Vol 11, Iss 1, p 121 (2022)
Histamines suppress epidermal keratinocyte differentiation. Previously, we reported that konjac ceramide (kCer) suppresses histamine-stimulated cell migration of HaCaT keratinocytes. kCer specifically binds to Nrp1 and does not interact with histamin
Externí odkaz:
https://doaj.org/article/25a808633b9143a1aa6c8538188d9c86
Publikováno v:
Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 160-167 (2016)
Dietary sphingolipids such as glucosylceramide (GlcCer) are potential nutritional factors associated with prevention of metabolic syndrome. Our current understanding is that dietary GlcCer is degraded to ceramide and further metabolized to sphingoid
Externí odkaz:
https://doaj.org/article/41f7b0c70cde4d8cb65f7b1c28653194
Autor:
Siddabasave Gowda B. Gowda, Seigo Usuki, Mostafa A.S. Hammam, Yuta Murai, Yasuyuki Igarashi, Kenji Monde
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 2, Pp 325-331 (2016)
Sphingoid base derivatives have attracted increasing attention as promising chemotherapeutic candidates against lifestyle diseases such as diabetes and cancer. Natural sphingoid bases can be a potential resource instead of those derived by time-consu
Externí odkaz:
https://doaj.org/article/235c8e5ef0884071b23ea4ec4da04320
Autor:
Seigo Usuki, Yoshiaki Yasutake, Noriko Tamura, Tomohiro Tamura, Kunikazu Tanji, Takashi Saitoh, Yuta Murai, Daisuke Mikami, Kohei Yuyama, Kenji Monde, Katsuyuki Mukai, Yasuyuki Igarashi
Publikováno v:
Cells, Vol 9, Iss 2, p 517 (2020)
Konjac ceramide (kCer) is a plant-type ceramide composed of various long-chain bases and α-hydroxyl fatty acids. The presence of d4t,8t-sphingadienine is essential for semaphorin 3A (Sema3A)-like activity. Herein, we examined the three neuropilin 1
Externí odkaz:
https://doaj.org/article/bd55715cca7643b8bd5dac654c36adf6
Publikováno v:
ASN Neuro, Vol 8 (2016)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive degeneration of upper and lower motor neurons. Although the etiology of ALS is obscure, genetic studies of familiar ALS suggest a multifactorial etiology
Externí odkaz:
https://doaj.org/article/9fe02c232f644fe28a01c0b072994d0b
Structural analysis of novel bioactive acylated steryl glucosides in pre-germinated brown rice bran1
Autor:
Seigo Usuki, Toshio Ariga, Somsankar Dasgupta, Takeshi Kasama, Keiko Morikawa, Shota Nonaka, Yasuhide Okuhara, Mitsuo Kise, Robert K. Yu
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 10, Pp 2188-2196 (2008)
Previous studies from our laboratory indicated that pre-germinated brown rice (PR) contained certain unknown bioactive lipids that activated two enzymes related to diabetes: Na+/K+ATPase and homocysteine-thiolactonase. In this paper, we report on the
Externí odkaz:
https://doaj.org/article/a0085f8b199b4bc889541040762d7f7d
Autor:
Seigo Usuki, Ying-Ying Tsai, Keiko Morikawa, Shota Nonaka, Yasuhide Okuhara, Mitsuo Kise, Robert K Yu
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28693 (2011)
BACKGROUND: The pathology of diabetic neuropathy involves oxidative stress on pancreatic β-cells, and is related to decreased levels of Insulin-like growth factor 1 (IGF-1). Acylated steryl β-glucoside (PR-ASG) found in pre-germiated brown rice is
Externí odkaz:
https://doaj.org/article/454596794be24cba9c36f101176e3678
Publikováno v:
Chirality. 34:807-812
Neuropathic pain is an unbearable condition caused by nervous system damage. As distinct acute pain, neuropathic pain is chronic, and it severely influences quality of life. N,N-Dimethyl-d-erythro-sphingosine (DMS), a neuropathic pain inducer, is met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e289514021ae0efa8fd1156f5a11615
https://doi.org/10.1002/chir.23433
https://doi.org/10.1002/chir.23433
Autor:
Yuta Murai, Takumi Honda, Kohei Yuyama, Daisuke Mikami, Koichi Eguchi, Yuichi Ukawa, Seigo Usuki, Yasuyuki Igarashi, Kenji Monde
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10751
The extracellular accumulation of aggregated amyloid-β (Aβ) in the brain leads to the early pathology of Alzheimer’s disease (AD). The administration of exogenous plant-type ceramides into AD model mice can promote the release of neuronal exosome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6026c40bba21fc83de1ca89b05e1e1e9