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Akademický článek

Tumor-isolated Cutibacterium acnes as an effective tumor suppressive living drug

Autor: Soudamini Sai Vimala Veera Chintalapati, Seigo Iwata, Mikako Miyahara, Eijiro Miyako

Publikováno v: Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 116041- (2024)

The two major challenges in cancer treatment are reducing the side effects and minimizing the cost of cancer treatment. A better therapy to treat cancer remains to be developed despite the presence of many therapeutic options. Here, we present bacter

Externí odkaz: https://doaj.org/article/dfc33ffcf207459f89f048db331a3e69

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Discovery of Intratumoral Oncolytic Bacteria Toward Targeted Anticancer Theranostics

Autor: Yamato Goto, Seigo Iwata, Mikako Miyahara, Eijiro Miyako

Publikováno v: Advanced Science.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0068cc5f93ff62396865270aee26c43e
https://doi.org/10.1002/advs.202301679

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Multimerization of small G-protein H-Ras induced by chemical modification at hyper variable region with caged compound

Autor: Shinsaku Maruta, Daiki Morita, Makoto Miyata, Seigo Iwata, Yuhei O Tahara, Yasunobu Sugimoto, Rufiat Nahar

Publikováno v: The Journal of Biochemistry. 171:215-225

The lipid-anchored small G protein Ras is a central regulator of cellular signal transduction processes, thereby functioning as a molecular switch. Ras forms a nanocluster on the plasma membrane by modifying lipids in the hypervariable region (HVR) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fce50d52db00de87ecd586b8aad84a00
https://doi.org/10.1093/jb/mvab120

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Discovery of intratumoral oncolytic bacteria toward targeted anticancer theranostics

Autor: Yamato Goto, Seigo Iwata, Eijiro Miyako

Unveiling the different biomedical functions of tumor-resident microbiota has remained challenging for the development of advanced anticancer medicines. Here we show that isolated intratumoral bacteria with its association with natural purple photosy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63027300dbce208179c8b3f29b9ff407
https://doi.org/10.1101/2022.10.25.513676

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Akademický článek

Interaction of a novel fluorescent GTP analogue with the small G-protein K-Ras.

Autor: Seigo Iwata¹, Kaori Masuhara², Nobuhisa Umeki³, Yasushi Sako³, Shinsaku Maruta^1,2 maruta@soka.ac.jp

Publikováno v: Journal of Biochemistry. Jan2016, Vol. 159 Issue 1, p41-48. 8p. 3 Diagrams, 2 Charts, 6 Graphs.

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GTP-dependent formation of straight tubulin oligomers leads to microtubule nucleation

Autor: Shinji Kamimura, Rie Ayukawa, Seigo Iwata, Benoît Gigant, Kien Xuan Ngo, Hiroshi Imai, Masahito Hayashi, Mikako Shirouzu, Itsushi Minoura, Ken Sekimoto, Etsuko Muto, Hideki Shigematsu, Tsukasa Makino, Seiichi Uchimura

Publikováno v: Journal of Cell Biology
Journal of Cell Biology, 2021, 220 (e202007033), ⟨10.1083/jcb.202007033⟩
Journal of Cell Biology, 2021, 220, ⟨10.1083/jcb.202007033⟩
Journal of Cell Biology, Rockefeller University Press, 2021, 220, ⟨10.1083/jcb.202007033⟩
The Journal of Cell Biology
'Journal of Cell Biology ', vol: 220, pages: e202007033-1-e202007033-19 (2021)

Ayukawa, Iwata, Imai, et al. visualize the early intermediates in the pathway of spontaneous nucleation of microtubules by using rapid flush negative stain electron microscopy. This study demonstrates that the formation of straight tubulin oligomers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb7d0964587e9adf6460d548336fe3e
https://hal.science/hal-03141626

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GTP-dependent formation of straight oligomers leads to nucleation of microtubules

Autor: Hideki Shigematsu, Seiichi Uchimura, Seigo Iwata, Tsukasa Makino, Etsuko Muto, Masahito Hayashi, Kien Xuan Ngo, Ken Sekimoto, Rie Ayukawa, Itsushi Minoura, Shinji Kamimura, Hiroshi Imai, Benoît Gigant, Mikako Shirouzu

Microtubule (MT) nucleation is essential for cellular activities, but its mechanism is not known because of the difficulty involved in capturing rare stochastic events in the early stage of polymerization. In cells, MTs are nucleated at tubulin conce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36041e6370843cb571f8e7661353d912
https://hal.archives-ouvertes.fr/hal-02990991/file/2020.03.05.979989v1.full.pdf

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Photocontrol of the GTPase activity of the small G protein K-Ras by using an azobenzene derivative

Autor: Seigo Iwata, Shinsaku Maruta

Publikováno v: Biochemistry and Biophysics Reports

The small G protein Ras is a central regulator of cellular signal transduction processes, functioning as a molecular switch. Switch mechanisms utilizing conformational changes in nucleotide-binding motifs have been well studied at the molecular level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04ecc5dea3856b99ae1574668512a30

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Interaction of a novel fluorescent GTP analogue with the small G-protein K-Ras

Autor: Nobuhisa Umeki, Kaori Masuhara, Shinsaku Maruta, Seigo Iwata, Yasushi Sako

Publikováno v: Journal of Biochemistry. 159:41-48

A novel fluorescent guanosine 5′-triphosphate (GTP) analogue, 2′(3′)-O-{6-(N-(7-nitrobenz-2-oxa-l,3-diazol-4-yl)amino) hexanoic}-GTP (NBD-GTP), was synthesized and utilized to monitor the effect of mutations in the functional region of mouse K-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88eee48c666868999e7d767e42de5bd8
https://doi.org/10.1093/jb/mvv071

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