Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Seigo Hatada"'
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21861 (2011)
The genome organization in pluripotent cells undergoing the first steps of differentiation is highly relevant to the reprogramming process in differentiation. Considering this fact, chromatin texture patterns that identify cells at the very early sta
Externí odkaz:
https://doaj.org/article/4dd1dc1a1b964224a0e45169fc872ce1
Autor:
Sigrid Eckardt, Ashley Yanchik, N. Adrian Leu, K. John McLaughlin, Seigo Hatada, Michael Kyba
Publikováno v:
Journal of Clinical Investigation. 121:623-627
To be of therapeutic use, autologous stem cells derived from patients with inherited genetic disorders require genetic modification via gene repair or insertion. Here, we present proof of principle that, for diseases associated with dominant alleles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625e3c80560808691ba06db87634cb03
https://doi.org/10.1172/jci45377
https://doi.org/10.1172/jci45377
Autor:
Harry M. Lightfoot, Michael LaPaglia, Bruce A. Cairns, Jeffrey H. Fair, Montserrat Caballero, Andrew Pleasant, Seigo Hatada
Publikováno v:
Journal of Surgical Research. 141:134-140
Background Embryonic stem (ES) cells have been investigated as a potential replacement therapy for failed organs, such as the liver. However, detection of hepatic engraftment from candidate stem cells has been difficult due to low engraftment efficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9fb1c9829bed6692ed2723db5c9a84
https://doi.org/10.1016/j.jss.2006.04.041
https://doi.org/10.1016/j.jss.2006.04.041
Autor:
Dhruv Sareen, Ho Won Kim, Jie Tang, Aparna Subramanian, Seigo Hatada, Berhan Mandefro, Vaithilingaraja Arumugaswami, Songyang Ren, Vincent Funari, Robert H. Baloh, Clive N. Svendsen
Publikováno v:
Stem cells translational medicine. 4(9)
Human pluripotent stem cells (hPSCs) are now being used for both disease modeling and cell therapy; however, efficient homologous recombination (HR) is often crucial to develop isogenic control or reporter lines. We showed that limited low-dose irrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c18a12579a5cb34d5367ec3aa00fd6
https://pubmed.ncbi.nlm.nih.gov/26185257
https://pubmed.ncbi.nlm.nih.gov/26185257
Autor:
Bruce A. Cairns, Michael LaPaglia, Hyung Suk Kim, Darrel W. Stafford, W. Andrew Pleasant, Seigo Hatada, Jeffrey A. Frelinger, Montserrat Caballero, Jeffrey H. Fair, Larysa H. Pevny, Anthony A. Meyer, Tong Gui, Oliver Smithies
Publikováno v:
Proceedings of the National Academy of Sciences. 102:2958-2963
Murine embryonic stem (ES) cells are pluripotent, but significant functional engraftment does not occur when they are introduced into the liver. However, here we demonstrate that functional liver engraftment does occur if the ES cells (from strain 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb9d8c672e354972bd1f7e59c90dda6
https://doi.org/10.1073/pnas.0409840102
https://doi.org/10.1073/pnas.0409840102
Autor:
Bruce A. Cairns, Anthony A. Meyer, Oliver Smithies, Hyung Suk Kim, Seigo Hatada, Jeffrey H. Fair, Michael LaPaglia, Jian Wang, Larysa H. Pevny
Publikováno v:
Surgery. 134:189-196
Background. Modifications in vitro have been used to direct embryonic stem (ES) cells toward endodermal phenotypes including hepatocytes; however, developmental correlates and evidence of biologic activity is lacking, and critical cell-cell interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234ee504c6066743335eb20cde9c65c5
https://doi.org/10.1067/msy.2003.225
https://doi.org/10.1067/msy.2003.225
Publikováno v:
Gene. 319
The human haptoglobin-related gene (HPR) gene codes for a haptoglobin-related protein (Hpr), a component of trypanosome lytic factor which circulates in plasma in small quantities. Except for the presence of a retrovirus-like element, RTVL-Ia, in int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1690c2372b8dccc80350d28af4e0b9cb
https://pubmed.ncbi.nlm.nih.gov/14597171
https://pubmed.ncbi.nlm.nih.gov/14597171
Autor:
Masao Kakoki, Hyung Suk Kim, Nobuyuki Takahashi, Yau Sheng Tsai, Oliver Smithies, Larry W. Arnold, Dominic Ciavatta, Nobuyo Maeda, Seigo Hatada
Publikováno v:
Developmental cell. 6(4)
Polymorphic differences altering expression of genes without changing their products probably underlie human quantitative traits affecting risks of serious diseases, but methods for investigating such quantitative differences in animals are limited.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2954b0f1d89ed0e8c21b31c7180fae0c
https://pubmed.ncbi.nlm.nih.gov/15068798
https://pubmed.ncbi.nlm.nih.gov/15068798
Publikováno v:
Molecular and biochemical parasitology. 119(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e0a2290cf6f4bde36fff9a1aefb6500
https://pubmed.ncbi.nlm.nih.gov/11814582
https://pubmed.ncbi.nlm.nih.gov/11814582
Homologous recombination (gene targeting) has many desirable features for gene therapy, because it can precisely correct mutant genes and restore their normal expression, and random nonhomologous integration of DNA is infrequent in cells in which hom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89056c5495eaa83d38fb6d2dd8224657
