Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Seigo, Sanoh"'
Autor:
Yoshitaka Tayama, Kazumi Sugihara, Seigo Sanoh, Katsushi Miyake, Shigeyuki Kitamura, Shigeru Ohta
Publikováno v:
Journal of Pharmaceutical Health Care and Sciences, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Background Allopurinol is used to treat hyperuricemia and gout. It is metabolized to oxypurinol by xanthine oxidase (XO), and aldehyde oxidase (AO). Allopurinol and oxypurinol are potent XO inhibitors that reduce the plasma uric acid levels.
Externí odkaz:
https://doaj.org/article/ce6e3b2e3f434a01ad80302182c4c6a3
Autor:
Kosuke Yoshida, Yuki Doi, Norihiko Iwazaki, Hidenori Yasuhara, Yuka Ikenaga, Hidetoshi Shimizu, Tomohisa Nakada, Tomoko Watanabe, Chise Tateno, Seigo Sanoh, Yaichiro Kotake
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 1, Pp 79-91 (2022)
Abstract Development of low‐clearance (CL) compounds that are slowly metabolized is a major goal in the pharmaceutical industry. However, the pursuit of low intrinsic CL (CLint) often leads to significant challenges in evaluating the pharmacokineti
Externí odkaz:
https://doaj.org/article/f898d1aa8cdb48d087447e2565b57de8
Publikováno v:
Current Research in Physiology, Vol 6, Iss , Pp 100100- (2023)
The present study clarified changes in physiological sensitivities of cultured Nieuwkoop and Faber stage 57 Xenopus laevis tadpole-organ-heart exposed to thyroxine (T4) using acetylcholine (ACh), norepinephrine (NE) and atropine. For preliminary life
Externí odkaz:
https://doaj.org/article/36b3243ee76c41b29fc2d677af4af152
Autor:
Yuya Ohtsuki1, Seigo Sanoh1,2 sanoh@wakayama-med.ac.jp, Mikaru Yamao3, Yuha Kojima3, Yaichiro Kotake1, Chise Tateno2,3,4 chise.mukaidani@phoenixbio.co.jp
Publikováno v:
Journal of Toxicological Sciences. 2023, Vol. 48 Issue 2, p99-108. 10p.
Autor:
Koya Sato1,2 koya.sato@astellas.com, Seigo Sanoh1,3 sanoh@wakayama-med.ac.jp, Yuji Ishida4,5, Chise Tateno3,4,5, Shigeru Ohta1,3, Yaichiro Kotake1
Publikováno v:
Journal of Toxicological Sciences. Jul2022, Vol. 47 Issue 7, p277-288. 12p.
Autor:
Keishi Ishida, Kazuki Takeda, Yuki Takehara, Tomoki Takabayashi, Masatsugu Miyara, Seigo Sanoh, Hidehiko Kawai, Shigeru Ohta, Yaichiro Kotake
Publikováno v:
Biological and Pharmaceutical Bulletin. 46:292-300
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::813d68e4d90ba65505bdac631513c0ae
https://doi.org/10.1248/bpb.b22-00744
https://doi.org/10.1248/bpb.b22-00744
Publikováno v:
The Journal of Biochemistry. 172:177-187
Increasing evidence suggests that trehalose, a non-reducing disaccharide, ameliorates disease phenotypes by activating autophagy in animal models of various human diseases, including neurodegenerative diseases. Multiple in vitro studies suggest that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4848d9542a370c2bca26160d0f1f46
https://doi.org/10.1093/jb/mvac051
https://doi.org/10.1093/jb/mvac051
Autor:
Chieri Fujino, Yoko Watanabe, Seigo Sanoh, Hiroyuki Nakajima, Naoto Uramaru, Hiroyuki Kojima, Kouichi Yoshinari, Shigeru Ohta, Shigeyuki Kitamura
Publikováno v:
Heliyon, Vol 5, Iss 9, Pp e02466- (2019)
In this study, we used reporter gene assays in COS-1 cells to examine the activation of rat pregnane X receptor (PXR), rat constitutive androstane receptor (CAR) and rat peroxisome-proliferator activated receptor (PPAR)α by pyrethroid pesticides, an
Externí odkaz:
https://doaj.org/article/3aa936cf2afd4a66a999cf55e88c40cd
Autor:
Yuki Doi, Hidetoshi Shimizu, Hidenori Yasuhara, Seigo Sanoh, Tomoko Watanabe, Norihiko Iwazaki, Yaichiro Kotake, Chise Tateno, Yuka Ikenaga, Kosuke Yoshida, Tomohisa Nakada
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 1, Pp 79-91 (2022)
Clinical and Translational Science
Clinical and Translational Science
Development of low‐clearance (CL) compounds that are slowly metabolized is a major goal in the pharmaceutical industry. However, the pursuit of low intrinsic CL (CLint) often leads to significant challenges in evaluating the pharmacokinetics of suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7637d6231eb9d24c530715918ca2fe2e
https://doaj.org/article/f898d1aa8cdb48d087447e2565b57de8
https://doaj.org/article/f898d1aa8cdb48d087447e2565b57de8
Autor:
Chihiro Sugiyama, Yaichiro Kotake, Masafumi Yamaguchi, Kanae Umeda, Yumi Tsuyama, Seigo Sanoh, Katsuhiro Okuda, Shigeru Ohta
Publikováno v:
Toxicology Reports, Vol 2, Iss C, Pp 450-460 (2015)
In vitro estimating strategies for potential neurotoxicity are required to screen multiple substances. In a previous study, we showed that exposure to low-concentrations of some chemicals, such as organotin, decreased the expression of GluR2 protein,
Externí odkaz:
https://doaj.org/article/119d3130a7834828b08cd92865156cb2