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Electroencephalographic, cognitive, and neurochemical effects of LY3130481 (CERC-611), a selective antagonist of TARP-γ8-associated AMPA receptors.

Autor: Witkin JM; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA. Electronic address: jwitkin@lilly.com., Li J; Lilly Research Laboratories, Eli Lilly and Company, Windlesham, Surrey, UK., Gilmour G; Lilly Research Laboratories, Eli Lilly and Company, Windlesham, Surrey, UK., Mitchell SN; Lilly Research Laboratories, Eli Lilly and Company, Windlesham, Surrey, UK., Carter G; Lilly Research Laboratories, Eli Lilly and Company, Windlesham, Surrey, UK., Gleason SD; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA., Seidel WF; Lilly Research Laboratories, Eli Lilly and Company, Windlesham, Surrey, UK., Eastwood BJ; Lilly Research Laboratories, Eli Lilly and Company, Windlesham, Surrey, UK., McCarthy A; Lilly Research Laboratories, Eli Lilly and Company, Windlesham, Surrey, UK., Porter WJ; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA., Reel J; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA., Gardinier KM; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA., Kato AS; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA., Wafford KA; Lilly Research Laboratories, Eli Lilly and Company, Windlesham, Surrey, UK. Electronic address: wafford_keith_allan@lilly.com.

Publikováno v: Neuropharmacology [Neuropharmacology] 2017 Nov; Vol. 126, pp. 257-270. Date of Electronic Publication: 2017 Jul 28.

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mGlu2/3 receptor antagonists for depression: overview of underlying mechanisms and clinical development.

Autor: Chaki, Shigeyuki¹ (AUTHOR) s-chaki@taisho.co.jp, Watanabe, Mai² (AUTHOR)

Publikováno v: European Archives of Psychiatry & Clinical Neuroscience. Oct2023, Vol. 273 Issue 7, p1451-1462. 12p. 2 Diagrams, 3 Charts.

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N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link between behavioral and central nervous system neurochemical changes.

Autor: Fell MJ; Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, DC0510, Indianapolis, IN 46285, USA. fell_matthew@lilly.com, Witkin JM, Falcone JF, Katner JS, Perry KW, Hart J, Rorick-Kehn L, Overshiner CD, Rasmussen K, Chaney SF, Benvenga MJ, Li X, Marlow DL, Thompson LK, Luecke SK, Wafford KA, Seidel WF, Edgar DM, Quets AT, Felder CC, Wang X, Heinz BA, Nikolayev A, Kuo MS, Mayhugh D, Khilevich A, Zhang D, Ebert PJ, Eckstein JA, Ackermann BL, Swanson SP, Catlow JT, Dean RA, Jackson K, Tauscher-Wisniewski S, Marek GJ, Schkeryantz JM, Svensson KA

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2011 Jan; Vol. 336 (1), pp. 165-77. Date of Electronic Publication: 2010 Oct 14.

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Altered norepinephrine transmission after spatial learning impairs sleep-mediated memory consolidation in rats.

Autor: Durán, Ernesto¹ (AUTHOR), Pandinelli, Martina¹ (AUTHOR), Logothetis, Nikos K.^1,2,3 (AUTHOR), Eschenko, Oxana¹ (AUTHOR) oxana.eschenko@tuebingen.mpg.de

Publikováno v: Scientific Reports. 3/14/2023, Vol. 13 Issue 1, p1-13. 13p.

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Compensatory sleep responses to wakefulness induced by the dopamine autoreceptor antagonist (-)DS121.

Autor: Olive MF; Sleep Disorders and Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA., Seidel WF, Edgar DM

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 1998 Jun; Vol. 285 (3), pp. 1073-83.

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Modafinil induces wakefulness without intensifying motor activity or subsequent rebound hypersomnolence in the rat.

Autor: Edgar DM; Sleep Disorders Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94304, USA., Seidel WF

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 1997 Nov; Vol. 283 (2), pp. 757-69.

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CCD-3693: an orally bioavailable analog of the endogenous neuroactive steroid, pregnanolone, demonstrates potent sedative hypnotic actions in the rat.

Autor: Edgar DM; Sleep Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304, USA., Seidel WF, Gee KW, Lan NC, Field G, Xia H, Hawkinson JE, Wieland S, Carter RB, Wood PL

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 1997 Jul; Vol. 282 (1), pp. 420-9.

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