Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Sei-ichi Araki"'
Autor:
Jun Sato, Katsuhiko Ono, Sei ichi Araki, Motoko Fukui, Shuji Nagasaki, Yasuhiro Miki, Noriaki Nakashima, Hironobu Sasano, Mitsui Isobe, Satoko Asano, Kazuhiro Takahashi
Publikováno v:
Molecular and Cellular Endocrinology. 395:32-40
TSH is the important regulator of thyroid function but detailed molecular mechanisms have not been clarified. We first generated the iodine deficient (ID) rat in which goiter is induced by accelerated endogenous TSH secretion. The result of microarra
Autor:
Shigeru Hisada, Norio Fukui, Shuji Nagasaki, Kuniyoshi Sakai, Mitsui Isobe, Yuko Hasegawa, Seiji Shibata, Motoko Fukui, Sei-ichi Araki
Publikováno v:
Journal of Toxicologic Pathology
The antithyroid drugs (ATDs) methimazole (MMI) and propylthiouracil (PTU) have been used for treatment of hyperthyroidism for more than several decades, despite the fact that they are associated with adverse drug reactions that are thought to be auto
Autor:
Hiroyuki Ando, Takashi Kitaguchi, Takeshi Kunimatsu, Katsuyuki Kazusa, Kiyoshi Takasuna, Sei-ichi Araki, Norimasa Miyamoto, Shinobu Suzuki, Keiichi Asakura
Publikováno v:
Journal of pharmacological and toxicological methods. 83
Recent increasing evidence suggests that the currently-used platforms in vitro IKr and APD, and/or in vivo QT assays are not fully predictive for TdP, and do not address potential arrhythmia (VT and/or VF) induced by diverse mechanisms of action. In