Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sei Kameoka"'
Autor:
Allyson Kwiatkowski, Carl Co, Sei Kameoka, An Zhang, John Coughlin, Tom Cameron, Eric Chiao, Svetlana Bergelson, Cullen Schmid Mason
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
The terminal sugars of Fc glycans can influence the Fc-dependent biological activities of monoclonal antibody therapeutics. Afucosylated N-glycans have been shown to significantly alter binding to FcγRIIIa and affect antibody-dependent cell-mediated
Externí odkaz:
https://doaj.org/article/de7297e0eace436aacfb3a8b6386340a
Autor:
John Coughlin, Allyson Kwiatkowski, Carl Co, Svetlana Bergelson, An Zhang, Cullen Schmid Mason, Eric Chiao, Sei Kameoka, Thomas Cameron
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The terminal sugars of Fc glycans can influence the Fc-dependent biological activities of monoclonal antibody therapeutics. Afucosylated N-glycans have been shown to significantly alter binding to FcγRIIIa and affect antibody-dependent cell-mediated
Autor:
Luke Barron, Jeremy S. Duffield, Sina A. Gharib, Mark L. Lupher, Richard M. Jack, Naoki Nakagawa, Sei Kameoka, Bryce G. Johnson, Allie M. Roach, Ivan G. Gomez
Pentraxin-2 (PTX-2), also known as serum amyloid P component (SAP/APCS), is a constitutive, antiinflammatory, innate immune plasma protein whose circulating level is decreased in chronic human fibrotic diseases. Here we show that recombinant human PT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f01f978eb8bfdbb86fbb5989dd808e
https://europepmc.org/articles/PMC5135274/
https://europepmc.org/articles/PMC5135274/
Autor:
Eric Chiao, Sei Kameoka
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781493966592
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bfbada57818dfc5cd340f0a4b326aed
https://doi.org/10.1007/978-1-4939-6661-5_2
https://doi.org/10.1007/978-1-4939-6661-5_2
Publikováno v:
Toxicological Sciences. 137:76-90
There is need in the pharmaceutical and chemical industries for high-throughput human cell-based assays for identifying hazardous chemicals, thereby reducing the overall reliance on animal studies for predicting the risk of toxic responses in humans.
Autor:
Kyle L. Kolaja, Liang Guo, Eric Chiao, Rory Abrams, J.D. Cohen, Sei Kameoka, Joshua E. Babiarz, J. Taunton
Publikováno v:
Toxicology and Applied Pharmacology. 257:74-83
Sunitinib, an oral tyrosine kinase inhibitor approved to treat advanced renal cell carcinoma and gastrointestinal stroma tumor, is associated with clinical cardiac toxicity. Although the precise mechanism of sunitinib cardiotoxicity is not known, bot
Autor:
Joshua E. Babiarz, Jennifer D. Cohen, Martin Sanders, Liang Guo, Eric Chiao, Sei Kameoka, Rory Abrams, Kyle L. Kolaja
Publikováno v:
Toxicological Sciences. 123:281-289
Improved in vitro systems for predicting drug-induced toxicity are needed in the pharmaceutical and biotechnology industries to decrease late-stage drug attrition. One unmet need is an early screen for cardiotoxicity, which accounts for about one thi
Publikováno v:
The EMBO Journal. 23:1782-1791
The functional coupling of transcription and splicing has been reported both in vivo and in vitro, but the molecular mechanisms governing these interactions remain largely unknown. Here we show that p54(nrb), a transcription/splicing factor, associat
Autor:
Yong-Zhen Xu, Tao Huang, Charles C. Query, Maria M. Konarska, Catherine M. Newnham, Sei Kameoka
Publikováno v:
The EMBO Journal. 23:376-385
Communication between U1 and U2 snRNPs is critical during pre-spliceosome assembly; yet, direct connections have not been observed. To investigate this assembly step, we focused on Prp5, an RNA-dependent ATPase of the DExD/H family. We identified hom
Publikováno v:
Cancer Letters. 146:161-167
Dietary flavonoids are known to scavenge free radicals but little information is available on their roles in antioxidant protein gene expression. The goal of this paper is to investigate the effect of flavonoid treatment on the antioxidant protein ex