Zobrazeno 1 - 10 of 28 pro vyhledávání: '"Sehon, CA"'
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Kniha
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7
Akademický článek
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
Autor: Harris PA, Faucher N; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., George N; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Eidam PM, King BW, White GV; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Anderson NA; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Bandyopadhyay D, Beal AM, Beneton V; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Berger SB, Campobasso N, Campos S; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Capriotti CA, Cox JA, Daugan A; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Donche F; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Fouchet MH; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Finger JN, Geddes B, Gough PJ, Grondin P; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Hoffman BL, Hoffman SJ, Hutchinson SE; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Jeong JU, Jigorel E; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Lamoureux P; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Leister LK, Lich JD, Mahajan MK, Meslamani J, Mosley JE; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Nagilla R, Nassau PM; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Ng SL, Ouellette MT, Pasikanti KK, Potvain F; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Reilly MA, Rivera EJ, Sautet S; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Schaeffer MC, Sehon CA, Sun H, Thorpe JH; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Totoritis RD, Ward P, Wellaway N; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Wisnoski DD, Woolven JM; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Bertin J, Marquis RW
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 May 23; Vol. 62 (10), pp. 5096-5110. Date of Electronic Publication: 2019 May 02.
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8
Akademický článek
Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.
Autor: Harris PA, Berger SB, Jeong JU, Nagilla R, Bandyopadhyay D, Campobasso N, Capriotti CA, Cox JA, Dare L, Dong X, Eidam PM, Finger JN, Hoffman SJ, Kang J, Kasparcova V, King BW, Lehr R, Lan Y, Leister LK, Lich JD, MacDonald TT; Centre for Immunobiology, Blizard Institute, Barts, and The London School of Medicine and Dentistry, Queen Mary University of London , E1 2AD London, U.K., Miller NA, Ouellette MT, Pao CS, Rahman A, Reilly MA, Rendina AR, Rivera EJ, Schaeffer MC, Sehon CA, Singhaus RR, Sun HH, Swift BA, Totoritis RD, Vossenkämper A; Centre for Immunobiology, Blizard Institute, Barts, and The London School of Medicine and Dentistry, Queen Mary University of London , E1 2AD London, U.K., Ward P, Wisnoski DD, Zhang D, Marquis RW, Gough PJ, Bertin J
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Feb 23; Vol. 60 (4), pp. 1247-1261. Date of Electronic Publication: 2017 Feb 10.
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9
Akademický článek
RIP3 induces apoptosis independent of pronecrotic kinase activity.
Autor: Mandal P; Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA., Berger SB; Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426, USA., Pillay S; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA., Moriwaki K; Department of Pathology, Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, MA 01605, USA., Huang C; Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA., Guo H; Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA., Lich JD; Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426, USA., Finger J; Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426, USA., Kasparcova V; Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426, USA., Votta B; Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426, USA., Ouellette M; Molecular Discovery Research, Platform Technologies and Science, GlaxoSmithKline, Collegeville, PA 19426, USA., King BW; Molecular Discovery Research, Platform Technologies and Science, GlaxoSmithKline, Collegeville, PA 19426, USA., Wisnoski D; Molecular Discovery Research, Platform Technologies and Science, GlaxoSmithKline, Collegeville, PA 19426, USA., Lakdawala AS; Molecular Discovery Research, Platform Technologies and Science, GlaxoSmithKline, Collegeville, PA 19426, USA., DeMartino MP; Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426, USA., Casillas LN; Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426, USA., Haile PA; Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426, USA., Sehon CA; Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426, USA., Marquis RW; Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426, USA., Upton J; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA., Daley-Bauer LP; Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA., Roback L; Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA., Ramia N; Department of Pathology, Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, MA 01605, USA., Dovey CM; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA., Carette JE; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA., Chan FK; Department of Pathology, Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, MA 01605, USA., Bertin J; Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426, USA., Gough PJ; Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426, USA., Mocarski ES; Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: mocarski@emory.edu., Kaiser WJ; Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: wkaiser@emory.edu.
Publikováno v: Molecular cell [Mol Cell] 2014 Nov 20; Vol. 56 (4), pp. 481-95. Date of Electronic Publication: 2014 Nov 20.
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10
Akademický článek
MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.
Autor: Dondelinger Y; VIB Inflammation Research Center, Technologiepark 927, 9052 Zwijnaarde-Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Zwijnaarde-Ghent, Belgium., Declercq W; VIB Inflammation Research Center, Technologiepark 927, 9052 Zwijnaarde-Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Zwijnaarde-Ghent, Belgium., Montessuit S; Department of Cell Biology, University of Geneva, 1211 Geneva 4, Switzerland., Roelandt R; VIB Inflammation Research Center, Technologiepark 927, 9052 Zwijnaarde-Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Zwijnaarde-Ghent, Belgium., Goncalves A; Microscopy Core Facility, VIB Inflammation Research Center, VIB/Ghent University, Technologiepark 927, 9052 Zwijnaarde-Ghent, Belgium., Bruggeman I; VIB Inflammation Research Center, Technologiepark 927, 9052 Zwijnaarde-Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Zwijnaarde-Ghent, Belgium., Hulpiau P; VIB Inflammation Research Center, Technologiepark 927, 9052 Zwijnaarde-Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Zwijnaarde-Ghent, Belgium., Weber K; VIB Inflammation Research Center, Technologiepark 927, 9052 Zwijnaarde-Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Zwijnaarde-Ghent, Belgium., Sehon CA; Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426, USA., Marquis RW; Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426, USA., Bertin J; Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426, USA., Gough PJ; Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426, USA., Savvides S; Unit for Structural Biology and Biophysics, Laboratory for Protein Biochemistry and Biomolecular Engineering, Ghent University, K.L. Ledeganckstraat 35, 9000 Ghent, Belgium., Martinou JC; Department of Cell Biology, University of Geneva, 1211 Geneva 4, Switzerland., Bertrand MJ; VIB Inflammation Research Center, Technologiepark 927, 9052 Zwijnaarde-Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Zwijnaarde-Ghent, Belgium., Vandenabeele P; VIB Inflammation Research Center, Technologiepark 927, 9052 Zwijnaarde-Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Zwijnaarde-Ghent, Belgium; Methusalem Program, Ghent University, Technologiepark 927, 9052 Zwijnaarde-Ghent, Belgium. Electronic address: peter.vandenabeele@irc.vib-ugent.be.
Publikováno v: Cell reports [Cell Rep] 2014 May 22; Vol. 7 (4), pp. 971-81. Date of Electronic Publication: 2014 May 09.
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