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Akademický článek

Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.

Autor: Harris PA, Faucher N; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., George N; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Eidam PM, King BW, White GV; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Anderson NA; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Bandyopadhyay D, Beal AM, Beneton V; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Berger SB, Campobasso N, Campos S; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Capriotti CA, Cox JA, Daugan A; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Donche F; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Fouchet MH; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Finger JN, Geddes B, Gough PJ, Grondin P; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Hoffman BL, Hoffman SJ, Hutchinson SE; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Jeong JU, Jigorel E; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Lamoureux P; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Leister LK, Lich JD, Mahajan MK, Meslamani J, Mosley JE; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Nagilla R, Nassau PM; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Ng SL, Ouellette MT, Pasikanti KK, Potvain F; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Reilly MA, Rivera EJ, Sautet S; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France., Schaeffer MC, Sehon CA, Sun H, Thorpe JH; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Totoritis RD, Ward P, Wellaway N; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Wisnoski DD, Woolven JM; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Bertin J, Marquis RW

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 May 23; Vol. 62 (10), pp. 5096-5110. Date of Electronic Publication: 2019 May 02.

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Akademický článek

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.

Autor: Harris PA, Berger SB, Jeong JU, Nagilla R, Bandyopadhyay D, Campobasso N, Capriotti CA, Cox JA, Dare L, Dong X, Eidam PM, Finger JN, Hoffman SJ, Kang J, Kasparcova V, King BW, Lehr R, Lan Y, Leister LK, Lich JD, MacDonald TT; Centre for Immunobiology, Blizard Institute, Barts, and The London School of Medicine and Dentistry, Queen Mary University of London , E1 2AD London, U.K., Miller NA, Ouellette MT, Pao CS, Rahman A, Reilly MA, Rendina AR, Rivera EJ, Schaeffer MC, Sehon CA, Singhaus RR, Sun HH, Swift BA, Totoritis RD, Vossenkämper A; Centre for Immunobiology, Blizard Institute, Barts, and The London School of Medicine and Dentistry, Queen Mary University of London , E1 2AD London, U.K., Ward P, Wisnoski DD, Zhang D, Marquis RW, Gough PJ, Bertin J

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Feb 23; Vol. 60 (4), pp. 1247-1261. Date of Electronic Publication: 2017 Feb 10.

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Akademický článek

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Akademický článek

Necroptosis and Its Involvement in Various Diseases.

Autor: Nakano H; Department of Biochemistry, Faculty of Medicine, Toho University School of Medicine, Tokyo, Japan. hiroyasu.nakano@med.toho-u.ac.jp.

Publikováno v: Advances in experimental medicine and biology [Adv Exp Med Biol] 2024; Vol. 1444, pp. 129-143.

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Akademický článek

Type I Interferon: Monkeypox/Mpox Viruses Achilles Heel?

Autor: Williams J; Biodesign Center for Immunotherapy, Vaccines and Virotherapy, Arizona State University, Tempe, USA.; ASU-Banner Center for Neurodegenerative Diseases, Arizona State University, Tempe, USA.; Biodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, USA., Bonner J; Biodesign Center for Immunotherapy, Vaccines and Virotherapy, Arizona State University, Tempe, USA.; ASU-Banner Center for Neurodegenerative Diseases, Arizona State University, Tempe, USA.; Biodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, USA.; School of Life Sciences, Arizona State University, Tempe, USA., Kibler K; Biodesign Center for Immunotherapy, Vaccines and Virotherapy, Arizona State University, Tempe, USA.; ASU-Banner Center for Neurodegenerative Diseases, Arizona State University, Tempe, USA.; Biodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, USA., Jacobs BL; Biodesign Center for Immunotherapy, Vaccines and Virotherapy, Arizona State University, Tempe, USA. bjacobs@asu.edu.; ASU-Banner Center for Neurodegenerative Diseases, Arizona State University, Tempe, USA. bjacobs@asu.edu.; Biodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, USA. bjacobs@asu.edu.; School of Life Sciences, Arizona State University, Tempe, USA. bjacobs@asu.edu.

Publikováno v: Advances in experimental medicine and biology [Adv Exp Med Biol] 2024; Vol. 1451, pp. 125-137.

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