Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sehmus Tohumeken"'
Autor:
Elizabeth L. Hardaker, Emilio Sanseviero, Ankur Karmokar, Devon Taylor, Marta Milo, Chrysis Michaloglou, Adina Hughes, Mimi Mai, Matthew King, Anisha Solanki, Lukasz Magiera, Ricardo Miragaia, Gozde Kar, Nathan Standifer, Michael Surace, Shaan Gill, Alison Peter, Sara Talbot, Sehmus Tohumeken, Henderson Fryer, Ali Mostafa, Kathy Mulgrew, Carolyn Lam, Scott Hoffmann, Daniel Sutton, Larissa Carnevalli, Fernando J. Calero-Nieto, Gemma N. Jones, Andrew J. Pierce, Zena Wilson, David Campbell, Lynet Nyoni, Carla P. Martins, Tamara Baker, Gilberto Serrano de Almeida, Zainab Ramlaoui, Abdel Bidar, Benjamin Phillips, Joseph Boland, Sonia Iyer, J. Carl Barrett, Arsene-Bienvenu Loembé, Serge Y. Fuchs, Umamaheswar Duvvuri, Pei-Jen Lou, Melonie A. Nance, Carlos Alberto Gomez Roca, Elaine Cadogan, Susan E. Critichlow, Steven Fawell, Mark Cobbold, Emma Dean, Viia Valge-Archer, Alan Lau, Dmitry I. Gabrilovich, Simon T. Barry
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The Ataxia telangiectasia and Rad3-related (ATR) inhibitor ceralasertib in combination with the PD-L1 antibody durvalumab demonstrated encouraging clinical benefit in melanoma and lung cancer patients who progressed on immunotherapy. Here we
Externí odkaz:
https://doaj.org/article/189773f2417346dcbdf8b6281d57effa
Autor:
Dmitry Gabrilovich, Simon Barry, Mark Cobbold, Sehmus Tohumeken, Kathy Mulgrew, Marta Milo, Emilio Sanseviero, Devon Taylor, Mimi Mai, Ali Mostafa, Serge Fuchs
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/cf813e0a4a104ae4b72e78732ed53681
Autor:
Sehmus Tohumeken, Pragney Deme, Seung Wan Yoo, Sujasha Gupta, Rana Rais, Barbara S. Slusher, Norman J. Haughey
Publikováno v:
Neurobiology of Disease, Vol 177, Iss , Pp 105987- (2023)
Extracellular vesicles (EVs) have been proposed to regulate the deposition of Aβ. Multiple publications have shown that APP, amyloid processing enzymes and Aβ peptides are associated with EVs. However, very little Aβ is associated with EVs compare
Externí odkaz:
https://doaj.org/article/9466fab8fdb04fdba31a3bc294aee098
Autor:
Regina Jitschin, Domenica Saul, Martina Braun, Sehmus Tohumeken, Simon Völkl, Roman Kischel, Michael Lutteropp, Cedric Dos Santos, Andreas Mackensen, Dimitrios Mougiakakos
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-6 (2018)
Abstract Acute myeloid leukemia (AML) is the most common acute leukemia amongst adults with a 5-year overall survival lower than 30%. Emerging evidence suggest that immune alterations favor leukemogenesis and/or AML relapse thereby negatively impacti
Externí odkaz:
https://doaj.org/article/1c9a3d273f454e1ba02104b527ded32d
Autor:
Dimitrios Mougiakakos, Regina Jitschin, Andreas Mackensen, Heiko Bruns, Andreas S. Baur, Simon Völkl, Domenica Saul, Martina Braun, Konstantinos Panagiotidis, Romy Loschinski, Andrej Stoll, Martin Böttcher, Rebecca Baur, Sehmus Tohumeken
(A) Induction of an MDSC phenotype by AML-derived soluble factors, (B) Induction of IDO-activity by AML-EVs, (C) ZetaView-based analysis of AML-EVs, and (D) Impact of chemotherapy on EV release by AML cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e4ad28cb125bc12ed2b43d6a9f02de
https://doi.org/10.1158/0008-5472.22426534
https://doi.org/10.1158/0008-5472.22426534
Autor:
Dimitrios Mougiakakos, Regina Jitschin, Andreas Mackensen, Heiko Bruns, Andreas S. Baur, Simon Völkl, Domenica Saul, Martina Braun, Konstantinos Panagiotidis, Romy Loschinski, Andrej Stoll, Martin Böttcher, Rebecca Baur, Sehmus Tohumeken
(A) Impact of anti-TLR4 antibodies on MDSC induction, (B) Impact of anti-TLR2 antibodies on pCREB activation, (C) Impact of PrK pre-treatment of AML-EV uptake, (D) Impact of chemotherapy on protein palmitoylation in AML-cells, and (E) Impact of 2-BP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4ad9dca2fc85631fed252e331b3faa
https://doi.org/10.1158/0008-5472.22426522
https://doi.org/10.1158/0008-5472.22426522
Autor:
Dimitrios Mougiakakos, Regina Jitschin, Andreas Mackensen, Heiko Bruns, Andreas S. Baur, Simon Völkl, Domenica Saul, Martina Braun, Konstantinos Panagiotidis, Romy Loschinski, Andrej Stoll, Martin Böttcher, Rebecca Baur, Sehmus Tohumeken
Changes of mitochondrial (A) membrane potential, (B) ROS production, and (C) mass in monocytes upon AML-EV uptake.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c357f0b4655e9015406cd23c3b4ee9d
https://doi.org/10.1158/0008-5472.22426525.v1
https://doi.org/10.1158/0008-5472.22426525.v1
Autor:
Dimitrios Mougiakakos, Regina Jitschin, Andreas Mackensen, Heiko Bruns, Andreas S. Baur, Simon Völkl, Domenica Saul, Martina Braun, Konstantinos Panagiotidis, Romy Loschinski, Andrej Stoll, Martin Böttcher, Rebecca Baur, Sehmus Tohumeken
(A) Induction of MDSCs by AML-EVs released by chemotherapy-pretreated AML celllines, (B) Phagocytotic activity of monocytes upon AML-EV uptake, (C) Induction of MDSCs by AML-EVs isolated by gradient ultracentrifugation, (D) Induction of pCREB by AML-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee028fa40086f9afac2923faf4ee47b
https://doi.org/10.1158/0008-5472.22426528.v1
https://doi.org/10.1158/0008-5472.22426528.v1
Autor:
Dimitrios Mougiakakos, Regina Jitschin, Andreas Mackensen, Heiko Bruns, Andreas S. Baur, Simon Völkl, Domenica Saul, Martina Braun, Konstantinos Panagiotidis, Romy Loschinski, Andrej Stoll, Martin Böttcher, Rebecca Baur, Sehmus Tohumeken
(A) CD33 expression on AML-EVs, (B) Cytokine-content of AML-EVs, (C) Localization analysis of AML-EVs in monocytes, (D) Control experiment regarding EV-independent uptake of PKH26.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30fae5addddb32e4133856cb4b761843
https://doi.org/10.1158/0008-5472.22426531.v1
https://doi.org/10.1158/0008-5472.22426531.v1
Autor:
Dimitrios Mougiakakos, Regina Jitschin, Andreas Mackensen, Heiko Bruns, Andreas S. Baur, Simon Völkl, Domenica Saul, Martina Braun, Konstantinos Panagiotidis, Romy Loschinski, Andrej Stoll, Martin Böttcher, Rebecca Baur, Sehmus Tohumeken
Acute myeloid leukemia (AML) represents the most common acute leukemia among adults. Despite recent progress in diagnosis and treatment, long-term outcome remains unsatisfactory. The success of allogeneic stem cell transplantation underscores the imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ee54c64953f897eeed67cf9c03c1b2
https://doi.org/10.1158/0008-5472.c.6512365
https://doi.org/10.1158/0008-5472.c.6512365